论文信息 - Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis

Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis

Members of the Pbx family are involved in a diverse range of developmental processes including axial patterning and organogenesis. Pbx functions are in part mediated by the interaction of Pbx proteins with members of the Hox and Meis/Prep families. We have identi®ed a fourth mammalian Pbx family member. Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and chromosome 19, respectively. Pbx4 expression is con®ned to the testis, especially to spermatocytes in the pachytene stage of the ®rst meiotic prophase. q 2001 Elsevier Science Ireland Ltd. All rights reserved.

[1] R. Benavente,et al. A novel Mr 77,000 protein of the XY body of mammalian spermatocytes: its localization in normal animals and in Searle’s translocation carriers , 1997, Chromosoma.

[2] M. Cleary,et al. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 , 1991, Molecular and cellular biology.

[3] R. Benavente,et al. XY body formation during rat spermatogenesis: an immunocytochemical study using antibodies against XY body-associated proteins , 1997, Chromosoma.

[4] T R Bürglin,et al. Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. , 1997, Nucleic acids research.

[5] A R Bellvé,et al. Purification, culture, and fractionation of spermatogenic cells. , 1993, Methods in enzymology.

[6] G Hermanson,et al. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. , 1990, Science.

[7] C. Sagerström,et al. A Novel Pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b , 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

[8] Michael L. Cleary,et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor , 1990, Cell.