Intracerebral hemorrhage despite prophylactic administration of vitamin K in infants--two case reports.

The incidence of vitamin K deficiency in infancy has decreased markedly, due to prophylactic administration of vitamin K during the neonatal period. However, vitamin K deficiency bleeding may occur during or after the neonatal period despite prophylactic administration in Japan. Two cases are reported of intracranial hemorrhage associated with coagulopathy in full-term infants who had received prophylactic administration of vitamin K. More reliable methods for prophylactic administration should be established.

[1]  M. Winckel,et al.  Vitamin K, an update for the paediatrician , 2009, European Journal of Pediatrics.

[2]  Edward R. Smith,et al.  Management of Stroke in Infants and Children: A Scientific Statement From a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young , 2008, Stroke.

[3]  N. Altınörs,et al.  Intracranial hemorrhages due to late-type vitamin K deficiency bleeding , 2008, Child's Nervous System.

[4]  M. H. Jørgensen,et al.  Prevention of Vitamin K Deficiency Bleeding in Breastfed Infants: Lessons From the Dutch and Danish Biliary Atresia Registries , 2008, Pediatrics.

[5]  Hirokazu Sakai,et al.  Vitamin K deficiency bleeding with intracranial hemorrhage: focus on secondary form , 2007, Emergency Radiology.

[6]  T. Fukao,et al.  Vitamin K-deficient intracranial hemorrhage as the first symptom of cytomegalovirus hepatitis with cholestasis. , 2007, The Tohoku journal of experimental medicine.

[7]  A. Sutor.  New Aspects of Vitamin K Prophylaxis , 2003, Seminars in thrombosis and hemostasis.

[8]  F. Ebbesen,et al.  Weekly oral vitamin K prophylaxis in Denmark , 2003, Acta paediatrica.

[9]  L. Quartulli,et al.  Intracranial hemorrhage associated with vitamin K deficiency in a breastfed infant after intramuscular vitamin K prophylaxis at birth. Follow‐up at 18 months , 2000, Acta paediatrica.

[10]  梁平,et al.  Surgical treatment for intracranial hematoma caused by delayed vitamin K deficiency bleeding in infants , 2000 .

[11]  R. von Kries,et al.  Can 3 oral 2 mg doses of vitamin K effectively prevent late vitamin K deficiency bleeding? , 1999, European Journal of Pediatrics.

[12]  T. Enomoto,et al.  Intracranial hemorrhage in an infant owing to vitamin K deficiency despite prophylaxis , 1999, Child's Nervous System.

[13]  R. von Kries,et al.  Vitamin K Deficiency Bleeding (VKDB) in Infancy , 1999, Thrombosis and Haemostasis.

[14]  A. Zipursky.  PREVENTION OF VITAMIN K DEFICIENCY BLEEDING IN NEWBORNS , 1999, British journal of haematology.

[15]  N. Dagres,et al.  Late form of Vitamin K Deficiency Bleeding in Germany , 1995, Klinische Padiatrie.

[16]  P. Loughnan,et al.  Epidemiology of late onset haemorrhagic disease: A pooled data analysis , 1993, Journal of paediatrics and child health.

[17]  R. von Kries,et al.  Vitamin K deficiency bleeding (VKDB) in infancy. ISTH Pediatric/Perinatal Subcommittee. International Society on Thrombosis and Haemostasis. , 1999, Thrombosis and haemostasis.

[18]  S. Aoki,et al.  [Intracranial hemorrhage in infancy due to vitamin K deficiency: report of a case with multiple intracerebral hematomas with ring-like high density figures]. , 1987, No to shinkei = Brain and nerve.

[19]  H. Dam,et al.  The relation of vitamin K deficiency to hemorrhagic disease of the newborn. , 1952, Advances in pediatrics.