Antenna Calibration Method for Dielectric Property Estimation of Biological Tissues at Microwave Frequencies

We aim to estimate the average dielectric properties of centimeter-scale volumes of biological tissues. A variety of approaches to measurement of dielectric properties of materials at microwave frequencies have been demonstrated in the literature and in practice. However, existing methods are not suitable for noninvasive measurement of in vivo biological tissues due to high property contrast with air, and the need to conform with the shape of the human body. To overcome this, a method of antenna calibration has been adapted and developed for use with an antenna system designed for biomedical applications, allowing for the estimation of permittivity and conductivity. This technique requires only two calibration procedures and does not require any special manufactured components. Simulated and measured results are presented between 3 to 8 GHz for materials with properties expected in biological tissues. Error bounds and an analysis of sources of error are provided.

[1]  M. Okoniewski,et al.  Precision open-ended coaxial probes for in vivo and ex vivo dielectric spectroscopy of biological tissues at microwave frequencies , 2005, IEEE Transactions on Microwave Theory and Techniques.

[2]  Elise C. Fear,et al.  Average Dielectric Property Analysis of Complex Breast Tissue with Microwave Transmission Measurements , 2015, Sensors.

[3]  Jie Liu,et al.  A free-space measurement of complex permittivity in 8GHz∼40GHz , 2014, 2014 Asia-Pacific Microwave Conference.

[4]  Jian Li,et al.  Wideband Reference-Plane Invariant Method for Measuring Electromagnetic Parameters of Materials , 2010, IEEE Transactions on Microwave Theory and Techniques.

[5]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[6]  Panagiotis Kosmas,et al.  Three-Dimensional Microwave Breast Imaging: Dispersive Dielectric Properties Estimation Using Patient-Specific Basis Functions , 2009, IEEE Transactions on Medical Imaging.

[7]  Shireen D. Geimer,et al.  Clinical Microwave Tomographic Imaging of the Calcaneus: A First-in-Human Case Study of Two Subjects , 2012, IEEE Transactions on Biomedical Engineering.

[8]  Jeremie Bourqui,et al.  System for Bulk Dielectric Permittivity Estimation of Breast Tissues at Microwave Frequencies , 2016, IEEE Transactions on Microwave Theory and Techniques.

[9]  C. Gabriel Dielectric properties of biological tissue: Variation with age , 2005, Bioelectromagnetics.

[10]  P.G. Bartley,et al.  Improved Free-Space S-Parameter Calibration , 2005, 2005 IEEE Instrumentationand Measurement Technology Conference Proceedings.

[11]  M. Kanda,et al.  Time domain sensors for radiated impulsive measurements , 1983 .

[12]  Antoine Diet,et al.  Quantitative Microwave Breast Phantom Imaging Using a Planar 2.45 GHz System , 2008 .

[13]  Elise C. Fear,et al.  Estimating the Effective Permittivity for Reconstructing Accurate Microwave-Radar Images , 2016, PloS one.

[14]  T. Nagaoka,et al.  Development of realistic high-resolution whole-body voxel models of Japanese adult males and females of average height and weight, and application of models to radio-frequency electromagnetic-field dosimetry. , 2004, Physics in medicine and biology.

[15]  W. Weir Automatic measurement of complex dielectric constant and permeability at microwave frequencies , 1974 .

[16]  Ilona Rolfes,et al.  Calibration methods for microwave free space measurements , 2005 .

[17]  Ramiro M. Irastorza,et al.  Noninvasive measurement of dielectric properties in layered structure: A system identification approach , 2009 .

[18]  Michal Okoniewski,et al.  Precision open-ended coaxial probe for dielectric spectroscopy of breast tissue , 2002, IEEE Antennas and Propagation Society International Symposium (IEEE Cat. No.02CH37313).

[19]  W. Nitz,et al.  On the heating of linear conductive structures as guide wires and catheters in interventional MRI , 2001, Journal of magnetic resonance imaging : JMRI.

[20]  Maryam Ravan,et al.  Near-Field Microwave Imaging Based on Aperture Raster Scanning With TEM Horn Antennas , 2011, IEEE Transactions on Antennas and Propagation.

[21]  Ram M. Narayanan,et al.  On the Opportunities and Challenges in Microwave Medical Sensing and Imaging , 2015, IEEE Transactions on Biomedical Engineering.

[22]  Ian Butterworth,et al.  A wearable physiological hydration monitoring wristband through multi-path non-contact dielectric spectroscopy in the microwave range , 2015, 2015 IEEE MTT-S 2015 International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO).

[23]  G.S.V. Raghavan,et al.  An Overview of Microwave Processing and Dielectric Properties of Agri-food Materials , 2004 .

[24]  S. J. Mason Feedback Theory-Further Properties of Signal Flow Graphs , 1956, Proceedings of the IRE.

[25]  M. Okoniewski,et al.  Highly Accurate Debye Models for Normal and Malignant Breast Tissue Dielectric Properties at Microwave Frequencies , 2007, IEEE Microwave and Wireless Components Letters.

[26]  G. F. Engen,et al.  Thru-Reflect-Line: An Improved Technique for Calibrating the Dual Six-Port Automatic Network Analyzer , 1979 .

[27]  E. C. Fear,et al.  Shielded UWB Sensor for Biomedical Applications , 2012, IEEE Antennas and Wireless Propagation Letters.

[28]  V. Varadan,et al.  Free-space measurement of complex permittivity and complex permeability of magnetic materials at microwave frequencies , 1990 .

[29]  Andreas Fhager,et al.  Microwave-Based Stroke Diagnosis Making Global Prehospital Thrombolytic Treatment Possible , 2014, IEEE Transactions on Biomedical Engineering.

[30]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.