OCT in the Management of Diabetic Macular Edema

Diabetic macular edema (DME) is the most common cause of mild-to-moderate visual loss in diabetes. With the introduction of anti-vascular endothelial growth factor therapies in addition to the previously available medical and laser therapies, OCT has become the cornerstone in the diagnosis, monitoring, therapeutic selection, and gauging response to therapy in eyes with DME. A review of the recent literature shows numerous advancements in the way OCT scanning is used both to monitor DME and to guide the management of DME.

[1]  Nagahisa Yoshimura,et al.  Association between Hyperreflective Foci in the Outer Retina, Status of Photoreceptor Layer and Visual Acuity in Diabetic Macular Edema Running title: Hyperreflective foci, photoreceptor layer, and VA in DME , 2018 .

[2]  Jennifer K. Sun,et al.  Observational study of subclinical diabetic macular edema , 2010, Eye.

[3]  Ali Erginay,et al.  Characterization of macular edema from various etiologies by optical coherence tomography. , 2005, American journal of ophthalmology.

[4]  Tien Yin Wong,et al.  Current Epidemiology of Diabetic Retinopathy and Diabetic Macular Edema , 2012, Current Diabetes Reports.

[5]  Q. Nguyen,et al.  Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema , 2012, Eye.

[6]  Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group. , 1985, Archives of ophthalmology.

[7]  J. L. Green,et al.  Vision-related quality of life in patients with diabetic macular oedema , 2007, British Journal of Ophthalmology.

[8]  Glenn J Jaffe,et al.  Evaluation of artifacts associated with macular spectral-domain optical coherence tomography. , 2010, Ophthalmology.

[9]  Francesco Bandello,et al.  Optical coherence tomography versus stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema: a systematic review. , 2007, Investigative ophthalmology & visual science.

[10]  Lloyd Paul Aiello,et al.  Reproducibility of macular thickness and volume using Zeiss optical coherence tomography in patients with diabetic macular edema. , 2007, Ophthalmology.

[11]  Lloyd Paul Aiello,et al.  Comparison of time-domain OCT and fundus photographic assessments of retinal thickening in eyes with diabetic macular edema. , 2008, Investigative ophthalmology & visual science.

[12]  Lala Ceklic,et al.  Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments. , 2009, Investigative ophthalmology & visual science.

[13]  Jay Chhablani,et al.  Characterization of diabetic microaneurysms by simultaneous fluorescein angiography and spectral-domain optical coherence tomography. , 2012, American journal of ophthalmology.

[14]  Elham Hatef,et al.  Association of retinal sensitivity to integrity of photoreceptor inner/outer segment junction in patients with diabetic macular edema. , 2013, Ophthalmology.

[15]  James W B Bainbridge,et al.  Repeatability of Spectralis OCT measurements of macular thickness and volume in diabetic macular edema. , 2012, Investigative ophthalmology & visual science.

[16]  S. G. Joe,et al.  The relationship between foveal ischemia and spectral-domain optical coherence tomography findings in ischemic diabetic macular edema. , 2013, Investigative ophthalmology & visual science.

[17]  L. Aiello,et al.  Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema. , 2006, Archives of ophthalmology.

[18]  Quan Dong Nguyen,et al.  Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. , 2012, Ophthalmology.

[19]  Lloyd Paul Aiello,et al.  Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema , 2010, Ophthalmology.

[20]  J. Duker,et al.  Optical coherence tomography – current and future applications , 2013, Current Opinion in Ophthalmology.

[21]  Igor Kozak,et al.  External limiting membrane as a predictor of visual improvement in diabetic macular edema after pars plana vitrectomy , 2012, Graefe's Archive for Clinical and Experimental Ophthalmology.

[22]  Francesco Bandello,et al.  Enhanced depth imaging optical coherence tomography in type 2 diabetes. , 2012, Investigative ophthalmology & visual science.

[23]  Milan Sonka,et al.  Quantification of external limiting membrane disruption caused by diabetic macular edema from SD-OCT. , 2012, Investigative ophthalmology & visual science.

[24]  Laurie Dustin,et al.  Relationship between optical coherence tomography retinal parameters and visual acuity in diabetic macular edema. , 2010, Ophthalmology.

[25]  Nagahisa Yoshimura,et al.  Optical coherence tomographic reflectivity of photoreceptors beneath cystoid spaces in diabetic macular edema. , 2012, Investigative ophthalmology & visual science.

[26]  S. Wolf,et al.  Behavior of SD-OCT-detected hyperreflective foci in the retina of anti-VEGF-treated patients with diabetic macular edema. , 2012, Investigative ophthalmology & visual science.

[27]  Don-Il Ham,et al.  The correlation between fluorescein angiographic and optical coherence tomographic features in clinically significant diabetic macular edema. , 2004, American journal of ophthalmology.

[28]  P Edwards Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema , 2010 .

[29]  T. Sano,et al.  [Diabetic retinopathy]. , 2001, Nihon rinsho. Japanese journal of clinical medicine.

[30]  Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema , 2011, Clinical ophthalmology.

[31]  Jay Chhablani,et al.  Characterization of microaneurysm closure after focal laser photocoagulation in diabetic macular edema. , 2013, American journal of ophthalmology.