3C-SiC on Si Hetero-epitaxial Growth for Electronic and Biomedical Applications

The growth of cubic silicon carbide on silicon, namely 3C-SiC/Si, has been extensively studied at the University of South Florida over the past decade and numerous electronic and biomedical applications explored using this material system. The key step to 3C-SiC devices is the growth of high-quality epitaxial layers of 3C-SiC. In order to improve the manufacturability of future 3CSiC devices, a simplified 3C-SiC growth process on 50 and 100 mm Si (100) substrates has been developed in a low-pressure horizontal hot-wall chemical vapor deposition (CVD) reactor. A simplified growth process consists of a single thermal ramp to the growth temperature followed by the 3C-SiC growth. The 3C-SiC epitaxial layers were characterized via optical microscopy, secondary electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), and secondary ion mass spectrometry (SIMS). Examples of biomedical devices realized with this material system are also introduced, including neural probes and in-vitro recording devices, as well as myoglobin and glucose biosensors.

[1]  S. Santavirta,et al.  Biocompatibility of silicon carbide in colony formation test in vitro , 1998, Archives of Orthopaedic and Trauma Surgery.

[2]  C. Coletti,et al.  Biocompatibility and wettability of crystalline SiC and Si surfaces , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[3]  M. Stutzmann,et al.  Organic functionalization of 3C-SiC surfaces. , 2013, ACS applied materials & interfaces.

[4]  S. Saddow,et al.  The Development of Silicon Carbide Based Electrode Devices for Central Nervous System Biomedical Implants , 2009 .

[5]  K E Muffly,et al.  Atomic force microscopy analysis of central nervous system cell morphology on silicon carbide and diamond substrates , 2009, Journal of molecular recognition : JMR.

[6]  S. Saddow,et al.  Implantable SiC based RF antenna biosensor for continuous glucose monitoring , 2013, 2013 IEEE SENSORS.

[7]  S. Saddow,et al.  A Biocompatible SiC RF Antenna for In-Vivo Sensing Applications , 2012 .

[8]  Stephen E. Saddow,et al.  Silicon carbide: a versatile material for biosensor applications , 2013, Biomedical Microdevices.

[9]  Christopher L. Frewin,et al.  SiC for Brain–Machine Interface (BMI) , 2012 .

[10]  Christopher L. Frewin,et al.  3C-SiC Films on Si for MEMS Applications: Mechanical Properties , 2009 .

[11]  Edwin J. Weeber,et al.  Single-crystal cubic silicon carbide: An in vivo biocompatible semiconductor for brain machine interface devices , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[12]  M. Reyes,et al.  Development of a high-growth rate 3C-SiC on Si CVD process , 2006 .

[13]  M. Reyes,et al.  Increased Growth Rates of 3C-SiC on Si (100) Substrates via HCl Growth Additive , 2007 .

[14]  Alexandra Oliveros Villalba Myoglobin Detection on SiC: Immunosensor Development for Myocardial Infarction , 2013 .

[15]  Y. Shishkin,et al.  High growth rates (>30 μm/h) of 4H–SiC epitaxial layers using a horizontal hot-wall CVD reactor , 2005 .

[16]  C. Coletti,et al.  Single-Crystal Silicon Carbide: A Biocompatible and Hemocompatible Semiconductor for Advanced Biomedical Applications , 2011 .

[17]  A. Spetz,et al.  Surface functionalization and biomedical applications based on SiC , 2007 .

[18]  U. Kalnins,et al.  Clinical outcomes of silicon carbide coated stents in patients with coronary artery disease. , 2002, Medical science monitor : international medical journal of experimental and clinical research.