Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging

[1]  S. Jazwinski,et al.  Loss of Mitochondrial Membrane Potential Triggers the Retrograde Response Extending Yeast Replicative Lifespan , 2012, Front. Gene..

[2]  G. Kroemer,et al.  Ceramide triggers metacaspase-independent mitochondrial cell death in yeast , 2011, Cell cycle.

[3]  D. Sinclair,et al.  Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase , 2011, EMBO reports.

[4]  L. Galluzzi,et al.  A yeast BH3‐only protein mediates the mitochondrial pathway of apoptosis , 2011, The EMBO journal.

[5]  Kellie J. Sims,et al.  Role for Sit4p‐dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p‐deficient cells , 2011, Molecular microbiology.

[6]  J. Vendrell,et al.  The stress‐activated protein kinase Hog1 develops a critical role after resting state , 2011, Molecular microbiology.

[7]  R. Hamanaka,et al.  Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. , 2010, Trends in biochemical sciences.

[8]  W. Burhans,et al.  Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity , 2010, Proceedings of the National Academy of Sciences.

[9]  M. Colombini,et al.  Regulation of ceramide channels by Bcl‐2 family proteins , 2010, FEBS letters.

[10]  Gary D Bader,et al.  The Genetic Landscape of a Cell , 2010, Science.

[11]  Q. Zhong,et al.  Loss of Cardiolipin Leads to Longevity Defects That Are Alleviated by Alterations in Stress Response Signaling* , 2009, The Journal of Biological Chemistry.

[12]  Y. Hannun,et al.  ISC1-dependent Metabolic Adaptation Reveals an Indispensable Role for Mitochondria in Induction of Nuclear Genes during the Diauxic Shift in Saccharomyces cerevisiae* , 2009, Journal of Biological Chemistry.

[13]  Javier Arroyo,et al.  The High Osmotic Response and Cell Wall Integrity Pathways Cooperate to Regulate Transcriptional Responses to Zymolyase-induced Cell Wall Stress in Saccharomyces cerevisiae* , 2009, Journal of Biological Chemistry.

[14]  Y. Hannun,et al.  Hydroxyurea Sensitivity Reveals a Role for ISC1 in the Regulation of G2/M* , 2009, Journal of Biological Chemistry.

[15]  C. Nombela,et al.  The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans. , 2009, Microbiology.

[16]  Michael P. Murphy,et al.  How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.

[17]  M. Konopleva,et al.  Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK , 2008, Cell cycle.

[18]  J. Thorner,et al.  Stress resistance and signal fidelity independent of nuclear MAPK function , 2008, Proceedings of the National Academy of Sciences.

[19]  Yusuf A. Hannun,et al.  Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.

[20]  Stefan Hohmann,et al.  Yeast osmoregulation. , 2007, Methods in enzymology.

[21]  C. Nombela,et al.  The sequential activation of the yeast HOG and SLT2 pathways is required for cell survival to cell wall stress. , 2007, Molecular biology of the cell.

[22]  S. Hohmann,et al.  Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. , 2007, Molecular biology of the cell.

[23]  Y. Hannun,et al.  Isc1 regulates sphingolipid metabolism in yeast mitochondria. , 2007, Biochimica et biophysica acta.

[24]  Joseph Avruch,et al.  MAP kinase pathways: the first twenty years. , 2007, Biochimica et biophysica acta.

[25]  M. Siderius,et al.  Cdc37p Is Required for Stress-Induced High-Osmolarity Glycerol and Protein Kinase C Mitogen-Activated Protein Kinase Pathway Functionality by Interaction with Hog1p and Slt2p (Mpk1p) , 2007, Eukaryotic Cell.

[26]  Stephan Sigrist,et al.  Endonuclease G regulates budding yeast life and death. , 2007, Molecular cell.

[27]  K. Struhl,et al.  The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress. , 2006, Molecular cell.

[28]  Roland L. Dunbrack,et al.  Regulation of the Oxidative Stress Response Through Slt2p-Dependent Destruction of Cyclin C in Saccharomyces cerevisiae , 2006, Genetics.

[29]  Y. Hannun,et al.  Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. , 2006, The Biochemical journal.

[30]  Matt Kaeberlein,et al.  Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients , 2005, Science.

[31]  S. Klassen,et al.  Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: A potential mechanism for loss of mitochondrial transmembrane potential and apoptosis , 2005, Molecular and Cellular Biochemistry.

[32]  B. Stoica,et al.  Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins , 2005, Molecular and Cellular Neuroscience.

[33]  David E. Levin,et al.  Cell Wall Integrity Signaling in Saccharomyces cerevisiae , 2005, Microbiology and Molecular Biology Reviews.

[34]  M. A. de la Torre-Ruiz,et al.  Pkc1 and the Upstream Elements of the Cell Integrity Pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, Are Required for Cellular Responses to Oxidative Stress* , 2005, Journal of Biological Chemistry.

[35]  Y. Hannun,et al.  The Phosphatidylglycerol/Cardiolipin Biosynthetic Pathway Is Required for the Activation of Inositol Phosphosphingolipid Phospholipase C, Isc1p, during Growth of Saccharomyces cerevisiae* , 2005, Journal of Biological Chemistry.

[36]  S. Jazwinski.  Yeast longevity and aging—the mitochondrial connection , 2005, Mechanisms of Ageing and Development.

[37]  M. Gustin,et al.  MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals. , 2004, American journal of physiology. Renal physiology.

[38]  S. Kurinna,et al.  Ceramide Promotes Apoptosis in Lung Cancer-Derived A549 Cells by a Mechanism Involving c-Jun NH2-Terminal Kinase , 2004, Cancer Research.

[39]  G. Kroemer,et al.  An AIF orthologue regulates apoptosis in yeast , 2004, The Journal of cell biology.

[40]  A. Ramne,et al.  Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance , 2004, Molecular microbiology.

[41]  T. Andersson,et al.  p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L). , 2004, Experimental cell research.

[42]  Gemma Reverter-Branchat,et al.  Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae , 2004, Journal of Biological Chemistry.

[43]  S. Jazwinski,et al.  Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity , 2004, Experimental Gerontology.

[44]  Ventsislava Y Petrova,et al.  Dual targeting of yeast catalase A to peroxisomes and mitochondria. , 2004, The Biochemical journal.

[45]  Y. Hannun,et al.  Activation and Localization of Inositol Phosphosphingolipid Phospholipase C, Isc1p, to the Mitochondria during Growth of Saccharomyces cerevisiae* , 2004, Journal of Biological Chemistry.

[46]  Eulàlia de Nadal,et al.  The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes , 2004, Nature.

[47]  U. Aebi,et al.  The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis , 2004, Journal of Cell Science.

[48]  I. Herskowitz,et al.  Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis. , 2003, Molecular biology of the cell.

[49]  R. Strich,et al.  Ask10p Mediates the Oxidative Stress-Induced Destruction of the Saccharomyces cerevisiae C-Type Cyclin Ume3p/Srb11p , 2003, Eukaryotic Cell.

[50]  J. François,et al.  The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae , 2003, Molecular microbiology.

[51]  S. Willaime-Morawek,et al.  C-jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis , 2003, Neuroscience.

[52]  V. Longo,et al.  The chronological life span of Saccharomyces cerevisiae , 2003, Methods in molecular biology.

[53]  F. Posas,et al.  Targeting the MEF2-Like Transcription Factor Smp1 by the Stress-Activated Hog1 Mitogen-Activated Protein Kinase , 2003, Molecular and Cellular Biology.

[54]  A. Quintanilha,et al.  Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7. , 2002, Free radical biology & medicine.

[55]  G. Fink,et al.  High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction , 2002, Molecular and Cellular Biology.

[56]  U. Jung,et al.  Regulation of the yeast Rlm1 transcription factor by the Mpk1 cell wall integrity MAP kinase , 2002, Molecular microbiology.

[57]  Paula Ludovico,et al.  Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. , 2002, Molecular biology of the cell.

[58]  D. Zajonc,et al.  ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. , 2002, European journal of biochemistry.

[59]  Eulàlia de Nadal,et al.  Dealing with osmostress through MAP kinase activation , 2002, EMBO reports.

[60]  J. Martín,et al.  Silencing of the Aspergillopepsin B (pepB) Gene of Aspergillus awamori by Antisense RNA Expression or Protease Removal by Gene Disruption Results in a Large Increase in Thaumatin Production , 2002, Applied and Environmental Microbiology.

[61]  J. Hahn,et al.  Regulation of the Saccharomyces cerevisiae Slt2 Kinase Pathway by the Stress-inducible Sdp1 Dual Specificity Phosphatase* , 2002, The Journal of Biological Chemistry.

[62]  Shuang Huang,et al.  Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence , 2002, Molecular and Cellular Biology.

[63]  I. Ota,et al.  Heat Stress Activates the Yeast High-Osmolarity Glycerol Mitogen-Activated Protein Kinase Pathway, and Protein Tyrosine Phosphatases Are Essential under Heat Stress , 2002, Eukaryotic Cell.

[64]  I. Kirkinezos,et al.  Reactive oxygen species and mitochondrial diseases. , 2001, Seminars in cell & developmental biology.

[65]  K. Gould,et al.  Coordination between fission yeast glucan formation and growth requires a sphingolipase activity. , 2001, Genetics.

[66]  Markus J. Tamás,et al.  The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway‐dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage , 2001, Molecular microbiology.

[67]  J. Caboche,et al.  Ceramide‐induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation , 2001, The European journal of neuroscience.

[68]  G. Ammerer,et al.  Stress-induced map kinase Hog1 is part of transcription activation complexes. , 2001, Molecular cell.

[69]  Y. Ohya,et al.  A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint , 2001, Nature Cell Biology.

[70]  E. de Nadal,et al.  Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress , 2001, The EMBO journal.

[71]  I. Ota,et al.  Differential Regulation of the Cell Wall Integrity Mitogen-Activated Protein Kinase Pathway in Budding Yeast by the Protein Tyrosine Phosphatases Ptp2 and Ptp3 , 1999, Molecular and Cellular Biology.

[72]  Michael N. Hall,et al.  Cell Wall Stress Depolarizes Cell Growth via Hyperactivation of Rho1 , 1999, The Journal of cell biology.

[73]  J. Thevelein,et al.  Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p , 1999, Molecular and Cellular Biology.

[74]  G. Ammerer,et al.  Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae. , 1999, Molecular biology of the cell.

[75]  M. Proft,et al.  The Ssn6–Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG‐dependent and ‐independent genes , 1998, The EMBO journal.

[76]  B. Ames,et al.  The free radical theory of aging matures. , 1998, Physiological reviews.

[77]  Francesc Posas,et al.  Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two‐component response regulator , 1998, The EMBO journal.

[78]  M. Snyder,et al.  SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway , 1997, Science.

[79]  T. Maeda,et al.  Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases , 1997, Molecular and cellular biology.

[80]  L. Johnston,et al.  Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity. , 1996, The EMBO journal.

[81]  A. Marchler-Bauer,et al.  The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). , 1996, The EMBO journal.

[82]  J. Broach,et al.  A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. , 1996, Genes & development.

[83]  C. Mazzoni,et al.  The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast. , 1996, The EMBO journal.

[84]  D. E. Levin,et al.  A Second Osmosensing Signal Transduction Pathway in Yeast , 1995, The Journal of Biological Chemistry.

[85]  John C. Lee,et al.  Human Mitogen-activated Protein Kinase CSBP1, but Not CSBP2, Complements a hog1 Deletion in Yeast (*) , 1995, The Journal of Biological Chemistry.

[86]  Michael E. Greenberg,et al.  Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis , 1995, Science.

[87]  H. Ruis,et al.  The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. , 1994, The EMBO journal.

[88]  R. Davis,et al.  An osmosensing signal transduction pathway in mammalian cells. , 1994, Science.

[89]  L Bibbs,et al.  A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. , 1994, Science.

[90]  D. Franklin,et al.  Cloning and characterization of LAG1, a longevity-assurance gene in yeast. , 1994, The Journal of biological chemistry.

[91]  Tatsuya Maeda,et al.  A two-component system that regulates an osmosensing MAP kinase cascade in yeast , 1994, Nature.

[92]  T. Maeda,et al.  Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae , 1993, Molecular and cellular biology.

[93]  E. Winter,et al.  An osmosensing signal transduction pathway in yeast. , 1993, Science.

[94]  M. Dante,et al.  Multifunctional yeast high-copy-number shuttle vectors. , 1992, Gene.

[95]  F. Klis,et al.  An assay of relative cell wall porosity in Saccharomyces cerevisiae, Kluyveromyces lactis and Schizosaccharomyces pombe , 1990, Yeast.

[96]  Z. D. Sharp,et al.  A general method for polyethylene-glycol-induced genetic transformation of bacteria and yeast. , 1983, Gene.

[97]  C. Nombela,et al.  The Hog 1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans , 2009 .

[98]  J. Clotet,et al.  Control of cell cycle in response to osmostress: lessons from yeast. , 2007, Methods in enzymology.

[99]  R. O. Poyton,et al.  Cytochrome-c oxidase from Saccharomyces cerevisiae. , 1995, Methods in enzymology.

[100]  D. Kidwell,et al.  Chromogenic substrates for horseradish peroxidase. , 1991, Analytical biochemistry.

[101]  M. Costanzo,et al.  Analysis and manipulation of yeast mitochondrial genes. , 1991, Methods in enzymology.