Conformations of the third hypervariable region in the VH domain of immunoglobulins.
暂无分享,去创建一个
A Tramontano | V Morea | A M Lesk | C Chothia | M Rustici | A. Lesk | C. Chothia | A. Tramontano | M. Rustici | V. Morea
[1] Haruki Nakamura,et al. Structural classification of CDR‐H3 in antibodies , 1996, FEBS letters.
[2] I. Wilson,et al. Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart. , 1994, Science.
[3] A. Lesk,et al. Standard conformations for the canonical structures of immunoglobulins. , 1997, Journal of molecular biology.
[4] R. Oomen,et al. Crystal structure to 2.45 Å resolution of a monoclonal Fab specific for the Brucella A cell wall polysaccharide antigen , 1993, Protein science : a publication of the Protein Society.
[5] Y. Li,et al. Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-A resolution. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[6] E. Haber,et al. Variable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[7] A Tramontano,et al. Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins. , 1990, Journal of molecular biology.
[8] A. Edmundson,et al. Three-dimensional structure of an Fv from a human IgM immunoglobulin. , 1992, Journal of molecular biology.
[9] I. Wilson,et al. Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex. , 1993, Journal of molecular biology.
[10] T. Bhat,et al. Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[11] J Navaza,et al. Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1. , 1994, Journal of molecular biology.
[12] W G Laver,et al. The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody. , 1994, Structure.
[13] D. Webster,et al. Antibody design: beyond the natural limits. , 1994, Trends in biotechnology.
[14] I. Tomlinson,et al. The human immunoglobulin VH repertoire. , 1995, Immunology today.
[15] A. Lesk,et al. Canonical structures for the hypervariable regions of immunoglobulins. , 1987, Journal of molecular biology.
[16] J. Skehel,et al. Refined three-dimensional structure of the Fab fragment of a murine IgGl,lambda antibody. , 1994, Acta crystallographica. Section D, Biological crystallography.
[17] J Deisenhofer,et al. Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 A and 1.0 A resolution. , 1980, Journal of molecular biology.
[18] R. Bruccoleri,et al. Computer analysis of mutations that affect antibody specificity , 1990, Proteins.
[19] Geraldine Taylor,et al. Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo , 1991, Bio/Technology.
[20] A. Lesk,et al. Conformations of immunoglobulin hypervariable regions , 1989, Nature.
[21] G J Williams,et al. The Protein Data Bank: a computer-based archival file for macromolecular structures. , 1977, Journal of molecular biology.
[22] Andrew J. Martin,et al. Structural families in loops of homologous proteins: automatic classification, modelling and application to antibodies. , 1996, Journal of molecular biology.
[23] J. Thornton,et al. Analysis and prediction of the different types of β-turn in proteins , 1988 .
[24] P. R. Sibbald,et al. CDR3 length in antigen-specific immune receptors , 1994, The Journal of experimental medicine.
[25] A R Rees,et al. Molecular modeling of antibody-combining sites. , 1995, Methods in molecular biology.
[26] C. Milstein,et al. Three‐dimensional structure determination of an anti‐2‐phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response. , 1990, The EMBO journal.
[27] A. Murzin,et al. The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[28] R. Kodandapani,et al. Crystal Structure of the OPG2 Fab , 1995, The Journal of Biological Chemistry.
[29] B C Finzel,et al. Three-dimensional structure of an antibody-antigen complex. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[30] M. Luo,et al. Structure of a monoclonal anti-ICAM-1 antibody R6.5 Fab fragment at 2.8 A resolution. , 1995, Acta Crystallographica Section D: Biological Crystallography.
[31] T. Bhat,et al. Bound water molecules and conformational stabilization help mediate an antigen-antibody association. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[32] C. Chothia,et al. Domain association in immunoglobulin molecules. The packing of variable domains. , 1985, Journal of molecular biology.
[33] Arthur M. Lesk,et al. Three-Dimensional Searching for Recurrent Structural Motifs in Data Bases of Protein Structures , 1994, J. Comput. Biol..
[34] Cyrus Chothia,et al. Transmission of conformational change in insulin , 1983, Nature.
[35] R. Poljak,et al. Crystal structure of human immunoglobulin fragment Fab new refined at 2.0 Å esolution , 1992, Proteins.
[36] G. Petsko,et al. Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten. , 1991, Biochemistry.
[37] T. Baker,et al. Structure determination of an Fab fragment that neutralizes human rhinovirus 14 and analysis of the Fab-virus complex. , 1994, Journal of molecular biology.
[38] A. Lesk,et al. Common features of the conformations of antigen‐binding loops in immunoglobulins and application to modeling loop conformations , 1992, Proteins.
[39] T. Blundell,et al. Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. , 1987, Protein engineering.
[40] M Levitt,et al. The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure , 1986, Science.
[41] B. L. Sibanda,et al. β-Hairpin families in globular proteins , 1985, Nature.
[43] R L Stanfield,et al. Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[44] Y. Satow,et al. Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A. , 1985, Journal of molecular biology.
[45] J. Brisson,et al. Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2-->8)-polysialic acid. , 1995, Biochemistry.
[46] E. Kabat,et al. Sequences of proteins of immunological interest , 1991 .
[47] A C Martin,et al. Modeling antibody hypervariable loops: a combined algorithm. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[48] B. L. Sibanda,et al. Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering. , 1989, Journal of molecular biology.
[49] W G Laver,et al. Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex. , 1992, Journal of molecular biology.
[50] Jiří Novotný,et al. Structure of antibody hypervariable loops reproduced by a conformational search algorithm , 1988, Nature.
[51] E. Padlan,et al. X-ray crystallography of antibodies. , 1996, Advances in protein chemistry.
[52] R. Poljak,et al. Structural patterns at residue positions 9, 18, 67 and 82 in the VH framework regions of human and murine immunoglobulins. , 1993, Journal of molecular biology.
[53] A Tramontano,et al. Antibody structure, prediction and redesign. , 1997, Biophysical chemistry.
[54] R. Williams,et al. Crystal structure of a diabody, a bivalent antibody fragment. , 1994, Structure.
[55] D. Wigley,et al. The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab. , 1994, Journal of molecular biology.
[56] Pedersen Jt. Molecular modelling of antibody combining sites. , 1993 .
[57] E. Milner,et al. Molecular characterization of the A/J J558 family of heavy chain variable region gene segments. , 1988, Journal of molecular biology.
[58] R L Stanfield,et al. Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. , 1992, Science.
[59] T. N. Bhat,et al. The Protein Data Bank , 2000, Nucleic Acids Res..
[60] K Aisaka,et al. Modeling the anti‐CEA antibody combining site by homology and conformational search , 1992, Proteins.
[61] I. Wilson,et al. CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN , 1993 .
[62] G. Rose,et al. Turns in peptides and proteins. , 1985, Advances in protein chemistry.
[63] A. Edmundson,et al. An autoantibody to single‐stranded DNA: Comparison of the three‐dimensional structures of the unliganded fab and a deoxynucleotide–fab complex , 1991, Proteins.
[64] J. Goding. 5 – Antibody Structure and Function , 1996 .
[65] R L Campbell,et al. 26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[66] A T Brünger,et al. 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten. , 1991, Journal of molecular biology.
[67] J. Schildbach,et al. Structure and specificity of the anti-digoxin antibody 40-50. , 1995, Journal of molecular biology.
[68] I. Wilson,et al. Structural evidence for induced fit as a mechanism for antibody-antigen recognition. , 1994, Science.
[69] T. Bhat,et al. The galactan‐binding immunoglobulin Fab J539: An x‐ray diffraction study at 2.6‐Å resolution , 1986, Proteins.
[70] T. A. Jones,et al. Using known substructures in protein model building and crystallography. , 1986, The EMBO journal.
[71] C. Betzel,et al. Three‐dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2 , 1992, Protein science : a publication of the Protein Society.
[72] Y. Li,et al. Preparation, characterization and crystallization of an antibody Fab fragment that recognizes RNA. Crystal structures of native Fab and three Fab-mononucleotide complexes. , 1995, Journal of molecular biology.
[73] L. Prasad,et al. Evaluation of mutagenesis for epitope mapping. Structure of an antibody-protein antigen complex. , 1994, The Journal of biological chemistry.
[74] A. Edmundson,et al. Local and transmitted conformational changes on complexation of an anti-sweetener Fab. , 1994, Journal of molecular biology.
[75] M. Cygler,et al. Conformation of complementarity determining region L1 loop in murine IgG lambda light chain extends the repertoire of canonical forms. , 1993, Journal of molecular biology.
[76] S. Tonegawa. Somatic generation of antibody diversity , 1983, Nature.
[77] R J Fletterick,et al. Crystal structure of a catalytic antibody with a serine protease active site. , 1994, Science.
[78] R A Houghten,et al. Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen. , 1994, Journal of molecular biology.
[79] C. Venkatachalam. Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units , 1968, Biopolymers.
[80] M. Shoham. Crystal structure of an anticholera toxin peptide complex at 2.3 A. , 1993, Journal of molecular biology.
[81] D Altschuh,et al. A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex. , 1992, Science.
[82] K. D. Hardman,et al. 1.85 A structure of anti-fluorescein 4-4-20 Fab. , 1995, Protein engineering.
[83] L. Presta,et al. X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. , 1993, Journal of molecular biology.