Stroke in a Young Patient: A Sentinel Presentation of Neurosyphilis and HIV (P2.109)

Objective: To describe a case of ischemic stroke in a young patient which resulted in diagnosis of concomitant neurosyphilis and HIV infections. Background: Meningovascular syphilis is an early manifestation of neurosyphilis which can lead to an infectious endarteritis (Heubner’s arteritis) and subsequent ischemic stroke. In the present era, early neurosyphilis is most frequently seen in patients with concomitant HIV infection, and previous series have demonstrated that neurosyphilis is a common sentinel presentation of HIV. However, clinicians may fail to inquire about at-risk behaviors and test for these infections in young stroke patients. Design/Methods: This is a case report of a young patient with multifocal ischemic stroke admitted to our institution. Results: A 19 year-old male with a history of migraine headaches, worsened over several months, presented to a community hospital after awakening with left-sided hemiplegia, numbness, and slurred speech. MRI brain revealed multifocal ischemic stroke in the middle cerebral artery territory and right cerebellum. After an unrevealing initial workup, he was transferred to our academic facility for further investigation. Cerebral angiogram revealed focal areas of high-grade stenosis affecting multiple vessels, and delayed filling of the intracranial circulation suggestive of vasculitis. Serum RPR was reactive, and the cerebrospinal fluid (CSF) revealed a neutrophilic pleocytosis with 423 WBC and reactive CSF VDRL. HIV testing returned positive. The patient disclosed a history of unprotected sexual relationships with multiple male partners. He did not have a personal history of sexually transmitted infections, nor was he aware of previous infected partners. Conclusions: Neurosyphilis should be a diagnostic consideration in young patients with ischemic stroke. Clinicians should be aware of the high incidence of concomitant syphilis and HIV in at-risk populations. Effort should be made to inquire about high-risk behaviors and initiate testing for these infections early in the diagnostic workup to avoid missing these crucial diagnoses. Disclosure: Dr. Flaherty has nothing to disclose. Dr. Cutting has received personal compensation for activities with F1000.