Nutrition in the intensive care unit

Nutritional support has become a routine part of the care of the critically ill patient. It is an adjunctive therapy, the main goal of which is to attenuate the development of malnutrition, yet the effectiveness of nutritional support is often thwarted by an underlying hostile metabolic milieu. This requires that these metabolic changes be taken into consideration when designing nutritional regimens for such patients. There is also a need to conduct large, multi-center studies to acquire more knowledge of the cost-benefit and cost effectiveness of nutritional support in the critically ill.

[1]  S. O’Rahilly,et al.  Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells , 1997, Diabetes.

[2]  H. Kehlet,et al.  Hormonal and neural blockade prevents the postoperative increase in amino acid clearance and urea synthesis. , 1992, Surgery.

[3]  H. Sewell,et al.  Intra-abdominal sepsis: an immunocytochemical study of the small intestine mucosa. , 1997, Journal of clinical pathology.

[4]  M. Jeevanandam,et al.  Substrate efficacy in early nutrition support of critically ill multiple trauma victims. , 1992, JPEN. Journal of parenteral and enteral nutrition.

[5]  J. Siepler,et al.  A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. , 1997, The Journal of trauma.

[6]  P. Bessey,et al.  Early Hormonal Changes Affect the Catabolic Response to Trauma , 1993, Annals of surgery.

[7]  J. Romijn,et al.  Infusion of long-chain or medium-chain triglycerides inhibits peripheral glucose metabolism in men. , 1994, JPEN. Journal of parenteral and enteral nutrition.

[8]  V. Šrámek,et al.  Glutamine and other amino acid losses during continuous venovenous hemodiafiltration. , 2008, Artificial organs.

[9]  H. Yki-Järvinen,et al.  Free fatty acid kinetics and oxidation in congestive heart failure. , 1998, The American journal of cardiology.

[10]  J. Macfie,et al.  The prevalence of gut translocation in humans. , 1994, Gastroenterology.

[11]  H. Yamamori,et al.  Effect of severity of stress on whole-body protein kinetics in surgical patients receiving parenteral nutrition. , 1996, Nutrition.

[12]  R. Wolfe,et al.  Herman Award Lecture, 1996: relation of metabolic studies to clinical nutrition--the example of burn injury. , 1996, The American journal of clinical nutrition.

[13]  G. Sacks.  Glutamine Supplementation in Catabolic Patients , 1999, The Annals of pharmacotherapy.

[14]  J. Fischer,et al.  Current uses and abuses of total parenteral nutrition. , 1996, Advances in surgery.

[15]  K. Feingold,et al.  Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms. , 1994, Cytokine.

[16]  T. Lipman,et al.  Bacterial translocation and enteral nutrition in humans: an outsider looks in. , 1995, JPEN. Journal of parenteral and enteral nutrition.

[17]  M. Hellerstein.  De novo lipogenesis in humans: metabolic and regulatory aspects , 1999, European Journal of Clinical Nutrition.

[18]  F. Cerra,et al.  Early enteral feeding does not attenuate metabolic response after blunt trauma. , 1993, The Journal of trauma.

[19]  R. Ross,et al.  Acquired growth hormone resistance in catabolic states. , 1996, Bailliere's clinical endocrinology and metabolism.

[20]  R. Griffiths,et al.  Randomized clinical outcome study of critically ill patients given glutamine-supplemented enteral nutrition. , 1999, Nutrition.

[21]  U. Ungerstedt,et al.  Influence of operation on glucose metabolism and lipolysis in human adipose tissue: a microdialysis study. , 1994, The European journal of surgery = Acta chirurgica.

[22]  M. Singer,et al.  Randomised trial of safety and efficacy of immediate postoperative enteral feeding in patients undergoing gastrointestinal resection , 1996, BMJ.

[23]  M. Salgado,et al.  Effect of total parenteral nutrition with different lipid emulsions of human monocyte and neutrophil functions. , 1997, Nutrition.

[24]  H. Heindorff.  The hepatic catabolic stress response. Hormonal regulation of urea synthesis after surgery. , 1993, Danish medical bulletin.

[25]  I. Valverde,et al.  Physiological Effect of Glucagon in Human Isolated Adipocytes , 1995, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[26]  M. McBurney.  The gut: central organ in nutrient requirements and metabolism. , 1994, Canadian journal of physiology and pharmacology.

[27]  C. O'Morain,et al.  Impaired gut barrier function in malnourished patients , 1996, The British journal of surgery.

[28]  D. Frankenfield,et al.  Nutritional effect of continuous hemodiafiltration. , 1995, Nutrition.

[29]  T. Lipman.  Grains or veins: is enteral nutrition really better than parenteral nutrition? A look at the evidence. , 1998, JPEN. Journal of parenteral and enteral nutrition.

[30]  O. Ljungqvist,et al.  Insulin resistance after abdominal surgery. , 1994, The British journal of surgery.

[31]  D. Chinkes,et al.  Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding. , 1997, The American journal of clinical nutrition.

[32]  S. Delikat,et al.  The metabolic effects of interleukin 1 beta on human bone marrow adipocytes. , 1995, Cytokine.

[33]  J. Revelly,et al.  Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. , 1998, Critical care medicine.

[34]  T. Hartung,et al.  Overactivation of the Immune System by Translocated Bacteria and Bacterial Products. , 1997, Scandinavian journal of gastroenterology.

[35]  T. Evans,et al.  Effects of enteral and parenteral nutrition on gut mucosal permeability in the critically ill. , 1995, American journal of respiratory and critical care medicine.

[36]  L. Walker,et al.  Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials. , 1999, Annals of surgery.

[37]  S. McClave,et al.  Clinical nutrition in pancreatitis. , 1997, Digestive diseases and sciences.

[38]  C. Obled,et al.  Insulin action on skeletal muscle protein metabolism during catabolic states. , 1999, Reproduction, nutrition, development.

[39]  J. F. Henning,et al.  Patterns and problems of adult total parenteral nutrition use in US academic medical centers. , 1998, Archives of surgery.

[40]  E. Barrett,et al.  The Role of Insulin and Other Hormones in the Regulation of Amino Acid and Protein Metabolism in Humans , 1998, Journal of basic and clinical physiology and pharmacology.

[41]  P. Arner,et al.  Lipolysis during abdominal surgery. , 1994, The Journal of clinical endocrinology and metabolism.

[42]  K. Ratheiser,et al.  Use of intravenous lipids in critically ill patients with sepsis without and with hepatic failure. , 1998, JPEN. Journal of parenteral and enteral nutrition.

[43]  R. Bellomo,et al.  A prospective comparative study of moderate versus high protein intake for critically ill patients with acute renal failure. , 1997, Renal failure.

[44]  G. Carey.  Mechanisms regulating adipocyte lipolysis. , 1998, Advances in experimental medicine and biology.

[45]  P. Frost,et al.  The route of nutritional support in the critically ill: physiological and economical considerations. , 1997, Nutrition.

[46]  J. Whelan,et al.  Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. , 1997, Critical care medicine.

[47]  E. Deitch,et al.  Role of the Gut in Multiple Organ Failure: Bacterial Translocation and Permeability Changes , 1996, World Journal of Surgery.

[48]  D. Heyland,et al.  Total parenteral nutrition in the critically ill patient: a meta-analysis. , 1998, JAMA.

[49]  L. Nelson,et al.  Predictors of total parenteral nutrition-induced lipogenesis. , 1994, Chest.

[50]  K. Alberti,et al.  The Effect of Laparoscopic Cholecystectomy on Insulin Sensitivity , 1994, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[51]  A. Prentice,et al.  Carbohydrates and Energy Balance , 1997, Annals of the New York Academy of Sciences.

[52]  K. Maclennan,et al.  Gut barrier function in malnourished patients , 1998, Gut.

[53]  E. Ferrannini,et al.  Insulin resistance of stress: sites and mechanisms. , 1993, Clinical science.

[54]  R. Bellantone,et al.  Structured versus long-chain triglycerides: a safety, tolerance, and efficacy randomized study in colorectal surgical patients. , 1999, JPEN. Journal of parenteral and enteral nutrition.

[55]  E. Jéquier,et al.  Carbohydrates as a source of energy. , 1994, The American journal of clinical nutrition.

[56]  P. Arner.  Differences in lipolysis between human subcutaneous and omental adipose tissues. , 1995, Annals of medicine.

[57]  J. Gornbein,et al.  Parenteral nutrition is associated with intestinal morphologic and functional changes in humans. , 1995, JPEN. Journal of parenteral and enteral nutrition.

[58]  M. Heslin,et al.  A prospective, randomized trial of early enteral feeding after resection of upper gastrointestinal malignancy. , 1997, Annals of surgery.

[59]  R. Wolfe,et al.  Effect of elevated free fatty acids on glucose oxidation in normal humans. , 1988, Metabolism: clinical and experimental.

[60]  K. Jeejeebhoy,et al.  Total parenteral nutrition in the critically ill patient. , 1986, Chest.

[61]  J. Arends,et al.  Gut permeability, intestinal morphology, and nutritional depletion. , 1998, Nutrition.

[62]  S. Boesby,et al.  Influence of postoperative enteral nutrition on postsurgical infections. , 1996, Gut.

[63]  R. Barrow,et al.  Effects of insulin on wound healing. , 1998, The Journal of trauma.

[64]  W. Schwesinger,et al.  Complications of needle catheter jejunostomy in 2,022 consecutive applications. , 1995, American journal of surgery.

[65]  B. Macfadyen,et al.  Endoscopic jejunal access for enteral feeding. , 1995, American journal of surgery.

[66]  P. Schneiter,et al.  Effects of infused amino acids and lipids on glucose metabolism in healthy lean humans. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[67]  S. Goldstein,et al.  The effects of injury and sepsis on fuel utilization. , 1989, Annual review of nutrition.

[68]  J. Watters,et al.  Uptake of glucose during continuous arteriovenous hemofiltration , 1993, Critical care medicine.

[69]  J. Mirtallo,et al.  Hyperglycemia associated with high, continuous infusion rates of total parenteral nutrition dextrose. , 1996, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[70]  S Groos,et al.  Parenteral versus enteral nutrition: morphological changes in human adult intestinal mucosa. , 1996, Journal of submicroscopic cytology and pathology.

[71]  J. Kehagias,et al.  Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: Results of a randomized prospective trial , 1997, The British journal of surgery.

[72]  T. Harrington,et al.  The benefits of early jejunal hyperalimentation in the head-injured patient. , 1989, Neurosurgery.

[73]  A. Bach,et al.  Structure and metabolic fate of triacylglycerol- and phospholipid-rich particles of commercial parenteral fat emulsions. , 1999, Nutrition.

[74]  S. Delikat,et al.  The metabolic effects of interleukin 1β on human bone marrow adipocytes , 1995 .

[75]  G. Biolo,et al.  Lipolysis in burned patients is stimulated by the beta 2-receptor for catecholamines. , 1994, Archives of surgery.

[76]  R. Wolfe.  Substrate utilization/insulin resistance in sepsis/trauma. , 1997, Bailliere's clinical endocrinology and metabolism.

[77]  J. H. Shaw,et al.  Anabolic and cardiovascular effects of recombinant human growth hormone in surgical patients with sepsis , 1996, The British journal of surgery.

[78]  P. Essén,et al.  Muscle protein synthesis after operation: effects of intravenous nutrition. , 1993, The European journal of surgery = Acta chirurgica.

[79]  J. Watters,et al.  Aging exaggerates the blood glucose response to total parenteral nutrition. , 1996, Canadian journal of surgery. Journal canadien de chirurgie.

[80]  R. Wolfe,et al.  Glucose metabolism in severely burned patients. , 1979, Metabolism: clinical and experimental.

[81]  P. Frascarolo,et al.  Effects of intravenously infused fish oil on platelet fatty acid phospholipid composition and on platelet function in postoperative trauma. , 1997, JPEN. Journal of parenteral and enteral nutrition.

[82]  P. Essén,et al.  Muscle protein synthesis rate decreases 24 hours after abdominal surgery irrespective of total parenteral nutrition. , 1996, JPEN. Journal of parenteral and enteral nutrition.

[83]  P. Calder,et al.  n-3 polyunsaturated fatty acids and cytokine production in health and disease. , 1997, Annals of nutrition & metabolism.

[84]  T. Ziegler,et al.  Glutamine: from basic science to clinical applications. , 1996, Nutrition.

[85]  R. Townsend,et al.  Changes in lipolytic sensitivity following repeated epinephrine infusion in humans. , 1994, The American journal of physiology.

[86]  J. Kinney,et al.  Metabolic Utilization of Intravenous Fat Emulsion During Total Parenteral Nutrition , 1982, Annals of surgery.

[87]  R. Smith,et al.  Regulation of glucose kinetics in trauma patients by insulin and glucagon. , 1992, Metabolism: clinical and experimental.

[88]  D. Chinkes,et al.  A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. , 1999, Annals of surgery.

[89]  J. Hall,et al.  Ischaemia-reperfusion injury to the intestine. , 1998, The Australian and New Zealand journal of surgery.

[90]  D. Gore,et al.  Catabolic hormones alone fail to reproduce the stress-induced efflux of amino acids. , 1994, Archives of surgery.

[91]  J. Nauta,et al.  Effects of human growth hormone on fuel utilization and mineral balance in critically ill patients on full intravenous nutritional support. , 1994, Journal of critical care.

[92]  C. Niesler,et al.  Tumor necrosis factor-alpha induces apoptosis of human adipose cells. , 1997, Diabetes.

[93]  K. Shirai,et al.  Catabolism of lipoprotein-X induced by infusion of 10% fat emulsion. , 1997, Nutrition.

[94]  G. Blackburn,et al.  Nutrition management in the ICU. , 1999, Chest.

[95]  P. Dayer,et al.  Effects of beta-blockade on energy metabolism following burns. , 1990, Burns : journal of the International Society for Burn Injuries.

[96]  L. Rue,et al.  Insulin‐Like Growth Factor‐1 Lowers Protein Oxidation in Patients with Thermal Injury , 1994, Annals of surgery.

[97]  J. Granneman.  Why do adipocytes make the β3 adrenergic receptor , 1995 .

[98]  J. Miles.  Lipid fuel metabolism in health and disease. , 1993, Current opinion in general surgery.

[99]  P. Singer,et al.  Hypercaloric glycerol in injured patients. , 1992, Surgery.

[100]  O. Ljungqvist,et al.  Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization. , 1999, American journal of physiology. Endocrinology and metabolism.

[101]  E. Moore,et al.  Early Enteral Feeding, Compared With Parenteral, Reduces Postoperative Septic Complications The Results of a Meta‐Analysis , 1992, Annals of surgery.

[102]  B. Bermejo,et al.  Eicosanoids and fat emulsions in acute respiratory distress syndrome patients. , 1997, Nutrition.

[103]  T. Harrington,et al.  The Benefits of Early Jejunal Hyperalimentation in the Head-Injured Patient , 1989 .

[104]  T. Suzuki,et al.  Serial changes in contribution of substrates to energy expenditure after transthoracic esophagectomy for cancer. , 1997, Nutrition.

[105]  A. Buchman,et al.  Glutamine: is it a conditionally required nutrient for the human gastrointestinal system? , 1996, Journal of the American College of Nutrition.

[106]  H. Vilstrup,et al.  Somatostatin prevents the postoperative increases in plasma amino acid clearance and urea synthesis after elective cholecystectomy. , 1995, Gut.

[107]  W. Sano,et al.  Effects of soybean oil emulsion and eicosapentaenoic acid on stress response and immune function after a severely stressful operation. , 1999, Annals of surgery.

[108]  M. Georgieff,et al.  Assessment of perioperative glycerol metabolism by stable isotope tracer technique. , 1996, Nutrition.

[109]  B. Beaufrère,et al.  Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[110]  D. Chinkes,et al.  Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment. , 1999, Annals of surgery.

[111]  J. Revelly,et al.  Energy metabolism in sepsis and injury. , 1997, Nutrition.

[112]  W. Simpson,et al.  Enteral nutritional support in acute alcoholic pancreatitis. , 1995, Journal of the American College of Nutrition.

[113]  I. Macdonald,et al.  Septic patients in multiple organ failure can oxidize infused glucose, but non-oxidative disposal (storage) is impaired. , 1995, Clinical science.

[114]  Miles Jm.  Lipid fuel metabolism in health and disease. , 1993 .

[115]  H. Ha.  The hepatic catabolic stress response. Hormonal regulation of urea synthesis after surgery. , 1993 .

[116]  D. Frankenfield,et al.  Amino acid loss and plasma concentration during continuous hemodiafiltration. , 1993, JPEN. Journal of parenteral and enteral nutrition.

[117]  J. Zierath,et al.  Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport. , 1998, American journal of physiology. Endocrinology and metabolism.

[118]  Preoperative total parenteral nutrition is not associated with mucosal atrophy or bacterial translocation in humans , 1995, The British journal of surgery.

[119]  C. Long,et al.  Insulin's anabolic effect is influenced by route of administration of nutrients. , 1999, Archives of surgery.

[120]  Acute response of human muscle protein to catabolic hormones. , 1993, Annals of surgery.