Wearable Natural Rubber Latex Gloves with Curcumin for Torn Glove Detection in Clinical Settings

Glove tear or perforation is a common occurrence during various activities that require gloves to be worn, posing a significant risk to the wearer and possibly others. This is vitally important in a clinical environment and particularly during surgical procedures. When a glove perforation occurs (and is noticed), the glove must be replaced as soon as possible; however, it is not always noticeable. The present article is focused on the design and development of a novel fluorescence-based sensing mechanism, which is integrated within the glove topology, to help alert the wearer of a perforation in situ. We hypothesized that natural rubber gloves with curcumin infused would yield fluorescence when the glove is damaged, particularly when torn or punctured. The glove design is based on double-dipping between Natural Rubber Latex (NRL) and an inner layer of latex mixed with curcumin, which results in a notable bright yellow-green emission when exposed to UV light. Curcumin (Cur) is a phenolic chemical found primarily in turmeric that fluoresces yellowish-green at 525 nm. The tear region on the glove will glow, indicating the presence of a Cur coating/dipping layer beneath. NRL film is modified by dipping it in a Cur dispersion solution mixed with NRL for the second dipping layer. Using Cur as a filler in NRL also has the distinct advantage of allowing the glove to be made stronger by evenly distributing it throughout the rubber phase. Herein, the optimized design is fully characterized, including physicochemical (fluorescence emission) and mechanical (tensile and tear tests) properties, highlighting the clear potential of this novel and low-cost approach for in situ torn glove detection.

[1]  S. Maher,et al.  Natural Rubber (NR) Latex Films with Antimicrobial Properties for Stethoscope Diaphragm Covers , 2022, Materials.

[2]  S. Nair,et al.  Development of a paper printed colorimetric sensor based on Cu-Curcumin nanoparticles for evolving point-of-care clinical diagnosis of sodium , 2022, Scientific Reports.

[3]  Zaixi Shu,et al.  Colorimetric ELISA based on urease catalysis curcumin as a ratiometric indicator for the sensitive determination of aflatoxin B1 in grain products. , 2022, Talanta.

[4]  T. Devasena,et al.  Curcumin Is an Iconic Ligand for Detecting Environmental Pollutants , 2022, Bioinorganic chemistry and applications.

[5]  R. El Kurdi,et al.  A Novel Study on the Self-Assembly Behavior of Poly(lactic-co-glycolic acid) Polymer Probed by Curcumin Fluorescence , 2022, ACS omega.

[6]  V. Sathya,et al.  Highly selective and sensitive response of curcumin thioether derivative for the detection of hypochlorous acid by fluorimetric method , 2022, Journal of the Iranian Chemical Society.

[7]  G. McGwin,et al.  Workplace Hazards in Orthopaedic Surgery Training: A Nationwide Resident Survey Involving Sharps-related Injuries , 2022, The Journal of the American Academy of Orthopaedic Surgeons.

[8]  R. El Kurdi,et al.  Curcumin embedded DBPC liposomes coated with chitosan layer as a fluorescence nanosensor for the selective detection of ribonucleic acid. , 2022, Luminescence : the journal of biological and chemical luminescence.

[9]  N. Huda,et al.  Development of curcumin/rice starch films for sensitive detection of hypoxanthine in chicken and fish meat , 2022, Carbohydrate Polymer Technologies and Applications.

[10]  Li Li,et al.  An insight into the in vivo imaging potential of curcumin analogues as fluorescence probes , 2020, Asian journal of pharmaceutical sciences.

[11]  M. Rezayi,et al.  The role of curcumin and its derivatives in sensory applications. , 2019, Materials science & engineering. C, Materials for biological applications.

[12]  A. Rusli,et al.  Effect of Latex Compound Dwell Time for the Production of Prototyped Biodegradable Natural Rubber Latex Gloves , 2019, IOP Conference Series: Materials Science and Engineering.

[13]  P. Show,et al.  Emerging crosslinking techniques for glove manufacturers with improved nitrile glove properties and reduced allergic risks , 2019, Materials Today Communications.

[14]  Yan Liu,et al.  Development of an Inner Filter Effects-Based Upconversion Nanoparticles-Curcumin Nanosystem for the Sensitive Sensing of Fluoride Ion. , 2017, ACS applied materials & interfaces.

[15]  K. Santhiya,et al.  Curcumin based chemosensor for selective detection of fluoride and cyanide anions in aqueous media , 2016, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[16]  E. Ameh,et al.  Glove Perforation Rate in Surgery: A Randomized, Controlled Study To Evaluate the Efficacy of Double Gloving. , 2016, Surgical infections.

[17]  Baoxing Wu,et al.  A novel highly selective chemosensor based on curcumin for detection of Cu2+ and its application for bioimaging , 2016 .

[18]  J. Owen,et al.  High Risk of Surgical Glove Perforation From Surgical Rotatory Instruments , 2016, Clinical orthopaedics and related research.

[19]  E. Alipour,et al.  Introducing curcumin as an electrochemical DNA hybridization indicator and its application for detection of human interleukin-2 gene , 2016, Journal of Solid State Electrochemistry.

[20]  Sangwoo Park,et al.  Significant enhancement of curcumin photoluminescence by a photosensitizing organogel: An optical sensor for pyrrole detection , 2015 .

[21]  S. Inoue,et al.  Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Aβ Plaques in Alzheimer's Disease. , 2015, Macromolecular bioscience.

[22]  G. Kolekar,et al.  A highly selective and sensitive single click novel fluorescent off–on sensor for copper and sulfide ions detection directly in aqueous solution using curcumin nanoparticles , 2015 .

[23]  Liqiang Zou,et al.  The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes , 2015, Molecules.

[24]  K. V. Lalitha,et al.  Synthesis of polyaniline hybrid composite: A new and efficient sensor for the detection of total volatile basic nitrogen molecules , 2015 .

[25]  N. Pourreza,et al.  Hemoglobin detection using curcumin nanoparticles as a colorimetric chemosensor , 2015 .

[26]  A. Imyim,et al.  Naked-eye and Colorimetric Detection of Arsenic(III) Using Difluoroboron-curcumin in Aqueous and Resin Bead Support Systems , 2014, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[27]  Jianlong Wang,et al.  Preparation and Structural Characterization of Hydroxylethyl Methacrylate Grafted Natural Rubber Latex , 2014 .

[28]  Roslim Ramli,et al.  Physical properties and fatigue lifecycles of natural rubber latex gloves , 2014 .

[29]  K. Park,et al.  A randomized prospective study of glove perforation in orthopaedic surgery: is a thick glove more effective? , 2013, The Journal of arthroplasty.

[30]  Maotian Xu,et al.  Naked-eye detection of Cys using simple molecular systems of curcumin and Hg2+ , 2013 .

[31]  J. Raoof,et al.  A novel voltammetric sensor for amoxicillin based on nickel-curcumin complex modified carbon paste electrode. , 2012, Bioelectrochemistry.

[32]  H. Ismail,et al.  Recycled Polyethylene Terephthalate Filled Natural Rubber Compounds: Effects of Filler Loading and Types of Matrix , 2011 .

[33]  H. Spikes,et al.  Laser-induced fluorescence for film thickness mapping in pure sliding lubricated, compliant, contacts , 2010 .

[34]  P. Prasassarakich,et al.  In situ silica reinforcement of natural rubber by sol–gel process via rubber solution , 2009 .

[35]  Zygmunt Gryczynski,et al.  Fluorescence amplification by electrochemically deposited silver nanowires with fractal architecture. , 2007, Journal of the American Chemical Society.

[36]  M. Ritter,et al.  Ultraviolet lighting during orthopaedic surgery and the rate of infection. , 2007, The Journal of bone and joint surgery. American volume.

[37]  K. Y. Chan,et al.  The rate of glove perforations in orthopaedic procedures: single versus double gloving. A prospective study. , 2006, The Medical journal of Malaysia.

[38]  J. Tanner Surgical Gloves: Perforation and Protection , 2006, Journal of perioperative practice.

[39]  J. Leong,et al.  Glove punctures in orthopaedic surgery , 2004, International Orthopaedics.

[40]  Ronald L St Germaine,et al.  Double gloving and practice attitudes among surgeons. , 2003, American journal of surgery.

[41]  M. Ritter,et al.  Operating room environment. , 1999, Clinical orthopaedics and related research.

[42]  S. L. Jensen,et al.  Surgical Gloves: Current Problems , 1999, World Journal of Surgery.

[43]  S. Guedes,et al.  THE MANUFACUTE OF GLOVES USING RVNRL: PARAMETERS OF the COAGULANT DIPPING PROCESS , 1998 .

[44]  A. M. Peacock,et al.  Surgical glove perforation , 1988, The British journal of surgery.