Thyroid sonomorphology, thyroid peroxidase antibodies and thyroid function

Summary Aim: Employees of Sanofi-Aventis Deutschland GmbH underwent thyroid screening in 2006 to assess new data about the prevalence of irregular sonomorphological pattern, elevated thyroid peroxidase antibodies (TPO AB) and thyroid function in an unselected adult German population. Participants, methods: The examination included 700 unselected employees. Blood samples were analyzed for serum TSH and TPO AB, and ultrasound of the thyroid was performed. Results: In 40.7% of the participants (n = 285) an irregular sonomorphological pattern was detected: goiter in 13.7%, nodules in 35.6%, nodular goiter in 8.6% and a hypoechogenic pattern of the thyroid gland in 20.4%. Serum TSH was increased in 3.9% and decreased in 0.6%. Elevated TPO AB values were observed in 13%. Only 1.4% (n= 10) showed elevated TPO AB combined with a TSH increase. Sonomorphological abnormalities were associated with increased TPO AB in 7.1%. Elevated TPO AB was observed significantly more often in combination with sonomorphological pathology (54.9%) than without (45.1%) (p = 0.003). Conclusions: Sonomorphological disorders are still very common in Germany and our results are comparable with previous screening examinations. Elevated TPO AB correlated significantly with the sonomorphological pattern of nodules and goiter. This may reflect an improved iodine supply or a hypertrophic stage of autoimmune thyroiditis in some cases.

[1]  A. Pinchera,et al.  Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hϋrthle cell thyroid lesions: results from a series of 505 consecutive patients , 2006, Clinical endocrinology.

[2]  O. Schober,et al.  Das “kleine” Schilddrüsenkarzinom , 2007, Nuklearmedizin.

[3]  M. Luster,et al.  Intra- and interobserver variability of thyroid volume measurements in healthy adults by 2D versus 3D ultrasound , 2007, Nuklearmedizin.

[4]  A. Agha,et al.  Papillary microcarcinoma and papillary cancer of the thyroid , 2007, Nuklearmedizin. Nuclear medicine.

[5]  K. Wegscheider,et al.  Management of multinodular goiter in Germany (Papillon 2005) , 2007, Nuklearmedizin.

[6]  U. John,et al.  Risk factors for goiter in a previously iodine-deficient region. , 2005, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[7]  U. John,et al.  Reference intervals of serum thyroid function tests in a previously iodine-deficient area. , 2005, Thyroid : official journal of the American Thyroid Association.

[8]  U. John,et al.  Reference intervals of serum thyroid function tests in a previously Iodine-deficient area , 2005 .

[9]  Karl Wegscheider,et al.  Prevalence of thyroid disorders in the working population of Germany: ultrasonography screening in 96,278 unselected employees. , 2004, Thyroid : official journal of the American Thyroid Association.

[10]  R. Gärtner.  [Subclinical hypothyroidism--does it have to be treated?]. , 2004, MMW Fortschritte der Medizin.

[11]  P. Schumm-Draeger.  [Diagnosis and treatment of benign goiter]. , 2004, MMW Fortschritte der Medizin.

[12]  M. Dietlein,et al.  Prevention, screening and therapy of thyroid diseases and their cost-effectiveness , 2003, Nuklearmedizin.

[13]  Henry Völzke,et al.  The prevalence of undiagnosed thyroid disorders in a previously iodine-deficient area. , 2003, Thyroid : official journal of the American Thyroid Association.

[14]  A. Tsatsoulis,et al.  High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern Greece. , 2003, Thyroid : official journal of the American Thyroid Association.

[15]  C. Reiners,et al.  [Thyroid gland ultrasound screening (Papillon Initiative). Report of 15 incidentally detected thyroid cancers]. , 2003, Der Internist.

[16]  B. Velkeniers,et al.  Thyroid dysfunction and autoimmunity in infertile women. , 2002, Thyroid : official journal of the American Thyroid Association.

[17]  W Harry Hannon,et al.  Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). , 2002, The Journal of clinical endocrinology and metabolism.

[18]  A. Pinchera,et al.  The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. , 1999, The Journal of clinical endocrinology and metabolism.

[19]  P. Mikosch,et al.  [Thyroid volume and iodine supply of 6 to 17 year old students. Results 3 years after the introduction of increased iodized salt]. , 1994, Nuklearmedizin. Nuclear medicine.

[20]  E. Reuter,et al.  [The diagnosis of clinically silent thyroid disorders]. , 1994, Nuklearmedizin. Nuclear medicine.

[21]  S. Takashima,et al.  Thyroid nodules associated with Hashimoto thyroiditis: assessment with US. , 1992, Radiology.

[22]  L. Kivisaari,et al.  Thyroid gland: US screening in middle-aged women with no previous thyroid disease. , 1989 .

[23]  J. Lissner,et al.  [Sonographic determination of thyroid volume. Comparison with other methods (author's transl)]. , 1981, Nuklearmedizin. Nuclear medicine.