Longitudinal Study of HTLV‐III‐Infected Chimpanzees by Lymphocyte Subpopulation Analysis

Following inoculation with plasma from human patients with AIDS, two chimpanzees demonstrated specific antihuman T‐cell leukemia virus type 3 (HTLV‐III) antibodies. One of the two chimpanzees also developed massive lymphadenopathy that persisted for 32 weeks and demonstrated a concurrent and more frequent depression of total T cells (T3) and T helper cells (T4) with a decrease in the ratios of T4 to T suppressor cells (T8). These results indicate that chimpanzees demonstrate a range of T‐cell subpopulations during infection and disease induced by HTLV‐III.

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