Differential effects of neuroleptic and other psychotropic agents on acquisition of avoidance in rats.

Abstract An avoidance acquisition procedure is presented and discussed, which is specifically sensitive to the effects of clinically effective antipsychotic (neuroleptic) agents and predictive of their clinical potency. The method distinguishes between such compounds and other classes of psychotropic agents. It utilizes experimentally naive rats, thereby obviating the need for maintaining colonies of trained animals, requires no training by the experimenter, and is rapid, requiring only a single, 50 minute test session.

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