Multicriteria steepest ascent

Abstract A simple multiresponse steepest ascent procedure has been developed by combining the standard steepest ascent method with multicriteria decision making. The steepest ascent method is one of the older methods in response surface methodology. It can be applied in optimization where the operability region is so large that a very complex function would be needed to fit an empirical function. With steepest ascent, local designs and local models in a part of the operability region are used to find a direction where the response is improved most. Experiments performed along a line in that direction will reveal the region of interest. There the response may be fitted with a second degree equation. The problem of multiresponse steepest ascent is that directions of improvement have to be combined into one direction. In general, the directions of improvement indicated by the individual responses are different and they may even be opposite. In this paper, steepest ascent has been adapted to the use of more responses by combination of the directions of steepest ascent to a simultaneous direction of interest. The combination is made by consideration of the obtainable improvements of the responses in the response space. These improvements can be calculated from the centre point (of the local design) response values and the response values at a fixed distance of the centre point. As an example, the method has been applied to a tablet optimization. This optimization problem had two responses and two independent variables.

[1]  Ewald Forster,et al.  Avoiding possible confusion in usual methods of steepest ascent calculation , 1990 .

[2]  Jan Hendrik de Boer Chemometrical aspects of quality in pharmaceutical technology: the application of robustness criteria and multi criteria decision making in optimization procedures for pharmaceutical formulations , 1992 .

[3]  J. Cornell Experiments with Mixtures: Designs, Models and the Analysis of Mixture Data , 1982 .

[4]  J. Cornell,et al.  Experiments with Mixtures , 1992 .

[5]  G. Derringer,et al.  Simultaneous Optimization of Several Response Variables , 1980 .

[6]  A. K. Smilde,et al.  Introduction of multi-criteria decision making in optimization procedures for pharmaceutical formulations , 1988 .

[7]  A. Smilde,et al.  Multicriteria decision making , 1992 .

[8]  Derek J. Pike,et al.  Empirical Model‐building and Response Surfaces. , 1988 .

[9]  P. Lewi,et al.  Multicriteria decision making using Pareto optimality and PROMETHEE preference ranking , 1992 .

[10]  J. S. Hunter,et al.  Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building. , 1979 .

[11]  Bertrand Mareschal,et al.  Prométhée: a new family of outranking methods in multicriteria analysis , 1984 .

[12]  Jean Pierre Brans,et al.  Multicriteria decision making: A case study , 1991 .

[13]  A. K. Smilde,et al.  Introduction of multi-criteria decision making in optimization procedures for high-performance liquid chromatographic separations , 1986 .