In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year.

[1]  H. Madry.  Surgical Therapy in Osteoarthritis. , 2022, Osteoarthritis and cartilage.

[2]  P. M. van der Kraan.  Inhibition of transforming growth factor-β in osteoarthritis. Discrepancy with reduced TGFβ signaling in normal joints , 2022, Osteoarthritis and cartilage open.

[3]  X. Guo,et al.  Mechanical stress determines the configuration of TGFβ activation in articular cartilage , 2021, Nature Communications.

[4]  D. Hart,et al.  Histological Analysis of Cartilage Defects Repaired with an Autologous Human Stem Cell Construct 48 Weeks Postimplantation Reveals Structural Details Not Detected by T2-Mapping MRI , 2021, Cartilage.

[5]  R. LaPrade,et al.  Chondral Lesions of the Knee: An Evidence-Based Approach. , 2021, The Journal of bone and joint surgery. American volume.

[6]  A. Gelber,et al.  Osteoarthritis , 2020, Annals of Internal Medicine.

[7]  Michael Weber,et al.  Potential Predictive Value of Axial T2 Mapping at 3 Tesla MRI in Patients with Untreated Patellar Cartilage Defects over a Mean Follow-up of Four Years. , 2020, Osteoarthritis and cartilage.

[8]  H. Madry,et al.  Topographic modeling of early human osteoarthritis in sheep , 2019, Science Translational Medicine.

[9]  Rui Wang,et al.  TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b , 2018, Cell cycle.

[10]  H. Madry,et al.  Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair , 2018, Nature Reviews Rheumatology.

[11]  D. Zurakowski,et al.  Effects of TGF-β Overexpression via rAAV Gene Transfer on the Early Repair Processes in an Osteochondral Defect Model in Minipigs , 2018, The American journal of sports medicine.

[12]  Jonathan R. Peterson,et al.  TGF-β Family Signaling in Mesenchymal Differentiation. , 2018, Cold Spring Harbor perspectives in biology.

[13]  P. M. van der Kraan.  Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint , 2018, Journal of bone metabolism.

[14]  D. Zurakowski,et al.  Sustained spatiotemporal release of TGF‐β1 confers enhanced very early chondrogenic differentiation during osteochondral repair in specific topographic patterns , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[15]  Xuedong Zhou,et al.  Transforming growth factor-β in stem cells and tissue homeostasis , 2018, Bone Research.

[16]  F. Luyten,et al.  Definition of a Critical Size Osteochondral Knee Defect and its Negative Effect on the Surrounding Articular Cartilage in the Rat , 2017, Osteoarthritis and cartilage.

[17]  M. Stuart,et al.  High Rate of Osteoarthritis After Osteochondritis Dissecans Fragment Excision Compared With Surgical Restoration at a Mean 16-Year Follow-up , 2017, The American journal of sports medicine.

[18]  Xiao-Fan Wang,et al.  TGF-β Family Signaling in the Control of Cell Proliferation and Survival. , 2017, Cold Spring Harbor perspectives in biology.

[19]  M. Nevitt,et al.  Brief Report: Partial‐ and Full‐Thickness Focal Cartilage Defects Contribute Equally to Development of New Cartilage Damage in Knee Osteoarthritis: The Multicenter Osteoarthritis Study , 2016, Arthritis & rheumatology.

[20]  Farshid Guilak,et al.  Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing , 2016, Proceedings of the National Academy of Sciences.

[21]  H. Madry,et al.  Gene therapy for human osteoarthritis: principles and clinical translation , 2016, Expert opinion on biological therapy.

[22]  Luigi Naldini,et al.  Gene therapy returns to centre stage , 2015, Nature.

[23]  Xiang Wang,et al.  Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways. , 2015, Molecular medicine reports.

[24]  A. Guermazi,et al.  Compositional MRI techniques for evaluation of cartilage degeneration in osteoarthritis. , 2015, Osteoarthritis and cartilage.

[25]  Johnny Huard,et al.  Gene therapy approaches to regenerating the musculoskeletal system , 2015, Nature Reviews Rheumatology.

[26]  D. Zurakowski,et al.  2D and 3D MOCART scoring systems assessed by 9.4 T high-field MRI correlate with elementary and complex histological scoring systems in a translational model of osteochondral repair. , 2014, Osteoarthritis and cartilage.

[27]  A. Rey-Rico,et al.  Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells , 2014, Stem Cell Research & Therapy.

[28]  Y. Koh,et al.  Overexpression of TGF-β1 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cells. , 2014, Biochemical and biophysical research communications.

[29]  H. Madry,et al.  Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo , 2014, Gene Therapy.

[30]  Xu Cao,et al.  Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis. , 2014, Trends in pharmacological sciences.

[31]  H. Fröhlich,et al.  TGF-beta1 Does Not Induce Senescence of Multipotent Mesenchymal Stromal Cells and Has Similar Effects in Early and Late Passages , 2013, PloS one.

[32]  A. Rey-Rico,et al.  rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ , 2013, Journal of Translational Medicine.

[33]  H. Madry,et al.  Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo , 2013, Journal of Molecular Medicine.

[34]  D. Zurakowski,et al.  Reduction of sample size requirements by bilateral versus unilateral research designs in animal models for cartilage tissue engineering. , 2013, Tissue engineering. Part C, Methods.

[35]  D. Zurakowski,et al.  Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo. , 2013, Osteoarthritis and cartilage.

[36]  A. Bücker,et al.  Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T--comparative evaluation of five macroscopic scoring systems in a large animal cartilage defect model. , 2012, Osteoarthritis and cartilage.

[37]  N. Theumann,et al.  [Imaging in osteoarthritis]. , 2012, Revue medicale suisse.

[38]  M. Goldring.  Articular Cartilage Degradation in Osteoarthritis , 2012, HSS Journal.

[39]  E. Strauss,et al.  The Role of Growth Factors in Cartilage Repair , 2011, Clinical orthopaedics and related research.

[40]  Yi Tang,et al.  TGF-β1-induced Migration of Bone Mesenchymal Stem Cells Couples Bone Resorption and Formation , 2009, Nature Medicine.

[41]  P. D. Kraan,et al.  TGF-β and osteoarthritis , 2007 .

[42]  R. Aikawa,et al.  Long-term stable expression of human growth hormone by rAAV promotes myocardial protection post-myocardial infarction. , 2007, Journal of molecular and cellular cardiology.

[43]  D. Zurakowski,et al.  Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[44]  E. Lechman,et al.  Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees , 2003, Arthritis research & therapy.

[45]  Steven B Cohen,et al.  Transforming growth factor-beta in calcium alginate beads for the treatment of articular cartilage defects in the rabbit. , 2002, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[46]  Thomas A Einhorn,et al.  Differential Temporal Expression of Members of the Transforming Growth Factor β Superfamily During Murine Fracture Healing , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  P. Sime,et al.  Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. , 2001, Osteoarthritis and cartilage.

[48]  J. Williams,et al.  Effect of transforming growth factor beta1 on chondrogenic differentiation of cultured equine mesenchymal stem cells. , 2000, American journal of veterinary research.

[49]  W. B. van den Berg,et al.  Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. , 1998, Osteoarthritis and cartilage.

[50]  E. Morris,et al.  The Effect of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) on the Healing of Full-Thickness Defects of Articular Cartilage* , 1997, The Journal of bone and joint surgery. American volume.

[51]  W. B. van den Berg,et al.  Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[52]  M J Glimcher,et al.  Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. , 1993, The Journal of bone and joint surgery. American volume.

[53]  W. B. van den Berg,et al.  Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo. , 1993, Annals of the rheumatic diseases.

[54]  A. Rey-Rico,et al.  Determination of the chondrogenic differentiation processes in human bone marrow-derived mesenchymal stem cells genetically modified to overexpress transforming growth factor-β via recombinant adeno-associated viral vectors. , 2014, Human gene therapy.

[55]  M. Shive,et al.  A polarized light microscopy method for accurate and reliable grading of collagen organization in cartilage repair. , 2011, Osteoarthritis and cartilage.

[56]  F. Barry,et al.  The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. , 2010, Osteoarthritis and cartilage.

[57]  Jörg Haller,et al.  Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. , 2006, European journal of radiology.

[58]  W. B. van den Berg,et al.  Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. , 2004, Arthritis and rheumatism.

[59]  D. Heymann,et al.  Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders. , 2002, Cytokine & growth factor reviews.

[60]  E B Hunziker,et al.  Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable? , 1999, Osteoarthritis and cartilage.