Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice

[1]  T. Renné,et al.  Factor XI deficiency in animal models , 2009, Journal of thrombosis and haemostasis : JTH.

[2]  O. McCarty,et al.  Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI. , 2009, Blood.

[3]  B. Monia,et al.  Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk. , 2010, Blood.

[4]  Mark F. Newman,et al.  Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. , 2001 .

[5]  Ruikang K. Wang,et al.  Thrombin Mutant W215A/E217A Treatment Improves Neurological Outcome and Reduces Cerebral Infarct Size in a Mouse Model of Ischemic Stroke , 2011, Stroke.

[6]  T. Renné,et al.  A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. , 2010, Blood.

[7]  K. Mann,et al.  Active tissue factor and activated factor XI in patients with acute ischemic cerebrovascular events , 2012, European journal of clinical investigation.

[8]  E. Gonzalez,et al.  Antiplatelet therapy in atherosclerotic cardiovascular disease. , 1998, Clinical therapeutics.

[9]  E. Liu,et al.  Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats. , 2007, European journal of pharmacology.

[10]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2011 update: a report from the American Heart Association. , 2011, Circulation.

[11]  E. Rosen,et al.  FXI Is Essential for Thrombus Formation Following FeCl3-Induced Injury of the Carotid Artery in the Mouse , 2002, Thrombosis and Haemostasis.

[12]  Daniel B Mark,et al.  Central nervous system injury associated with cardiac surgery , 2006, The Lancet.

[13]  T. Renné,et al.  Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis , 2006, The Journal of experimental medicine.

[14]  G. Feuerstein,et al.  Effects of factor IX or factor XI deficiency on ferric chloride‐induced carotid artery occlusion in mice , 2005, Journal of thrombosis and haemostasis : JTH.

[15]  M. Creager.  Results of the CAPRIE trial: efficacy and safety of clopidogrel , 1998, Vascular medicine.

[16]  Tao Yang,et al.  Multiple Preconditioning Paradigms Converge on Interferon Regulatory Factor-Dependent Signaling to Promote Tolerance to Ischemic Brain Injury , 2011, The Journal of Neuroscience.

[17]  N. Mackman,et al.  Tissue factor: past, present, and future. , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[18]  K. Mann,et al.  Circulating activated factor XI and active tissue factor as predictors of worse prognosis in patients following ischemic cerebrovascular events. , 2011, Thrombosis research.

[19]  H. Steinmetz,et al.  Increased Risk of Hemorrhagic Transformation in Ischemic Stroke Occurring During Warfarin Anticoagulation: An Experimental Study in Mice , 2011, Stroke.

[20]  S. Thomas Carmichael,et al.  Rodent models of focal stroke: Size, mechanism, and purpose , 2005, NeuroRX.

[21]  A. Gruber,et al.  Factor XI contributes to thrombin generation in the absence of factor XII. , 2008, Blood.

[22]  K. Hossmann,et al.  Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice. , 1999, Neuroreport.

[23]  C. Hack,et al.  Enhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In vivo evidence for a role of factor XI as an anti-fibrinolytic factor. , 1998, The Journal of clinical investigation.

[24]  E. Braunwald,et al.  Novel oral anticoagulants: focus on stroke prevention and treatment of venous thrombo-embolism. , 2011, European heart journal.

[25]  A. Gruber,et al.  Factor XI-dependence of surface- and tissue factor-initiated thrombus propagation in primates. , 2003, Blood.

[26]  U. Seligsohn.  Factor XI deficiency in humans , 2009, Journal of thrombosis and haemostasis : JTH.

[27]  T. Renné,et al.  The intrinsic pathway of coagulation: a target for treating thromboembolic disease? , 2007, Journal of thrombosis and haemostasis : JTH.

[28]  D. Tanné,et al.  Reduced incidence of ischemic stroke in patients with severe factor XI deficiency. , 2008, Blood.

[29]  M. Kaste,et al.  The European Cooperative Acute Stroke Study (ECASS) , 1993 .

[30]  A. Folsom,et al.  Novel Hemostatic Factor Levels and Risk of Ischemic Stroke: The Atherosclerosis Risk in Communities (ARIC) Study , 2010, Cerebrovascular Diseases.

[31]  Y. Asada,et al.  Factor XI contributes to thrombus propagation on injured neointima of the rabbit iliac artery , 2006, Journal of thrombosis and haemostasis : JTH.

[32]  Christopher R. Emerson,et al.  Rivaroxaban: A Novel, Oral, Direct Factor Xa Inhibitor , 2009, Pharmacotherapy.

[33]  J. Meijers.  Feedback controversy stops here. , 2009, Blood.

[34]  M. Kaste,et al.  Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) , 1995, JAMA.