Role of Calcium in Acute Hyperthermic Myocardial Injury

Hyperthermic Myocardial Injury. Introduction: We hypothesized that intracellular calcium overload may play an important role in heat‐induced myocardial injury. This postulate was investigated using a model of isolated guinea pig papillary muscle in which resting tension was measured as an indirect indicator of cytosolic free‐calcium concentration and the fluorescence changes of Fluo‐3 AM dye was measured as a direct indicator of cytosolic free‐calcium concentration.

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