Surface fluid-swellable chitosan fiber as the wound dressing material.

The objective of this study was to develop a novel surface fluid-swellable chitosan (SFSC) fiber for potential wound dressing. The SFSC fiber was successfully prepared by surface modification of chitosan fiber with succinic anhydride, which was characterized by FTIR and solid-state (13)C NMR. The SFSC fiber exhibited better water absorption capacity (approx. 2980%) and stronger antibacterial activities (both above 90%) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) than chitosan fiber (both below 75%). The cell viability was more than 90% after treated with the SFSC fiber extract, which demonstrated that SFSC fiber had low cytotoxicity towards mouse embryo fibroblasts (MEFs). The SFSC fiber could promote wound healing with advanced development of granulation tissue and epithelial coverage compared with the control (gauze-covered) group. The results indicated that SFSC fiber had great potential to be used as wound dressing material.

[1]  M. Zilberman,et al.  In vitro microbial inhibition and cellular response to novel biodegradable composite wound dressings with controlled release of antibiotics. , 2011, Acta biomaterialia.

[2]  Qingsheng Wu,et al.  The Synergistic Antibacterial Effects of Water Soluble N-succinyl-chitosan with Ceftriaxone against Escherichia coli , 2012 .

[3]  Emir Baki Denkbaş,et al.  Preparation and characterization of ciprofloxacin-loaded alginate/chitosan sponge as a wound dressing material , 2006 .

[4]  Stephen C. Moratti,et al.  Antimicrobial Properties of a Chitosan Dextran-Based Hydrogel for Surgical Use , 2011, Antimicrobial Agents and Chemotherapy.

[5]  Willi Paul,et al.  Chitosan and Alginate Wound Dressings: A Short Review , 2004 .

[6]  Y. Kuroyanagi,et al.  Development of a new wound dressing with antimicrobial delivery capability , 1994, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[7]  Xiguang Chen,et al.  Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: in vitro and in vivo evaluation. , 2013, International journal of pharmaceutics.

[8]  K. Lozano,et al.  Development of tannic acid/chitosan/pullulan composite nanofibers from aqueous solution for potential applications as wound dressing. , 2015, Carbohydrate polymers.

[9]  S. Rossi,et al.  Wound dressings based on silver sulfadiazine solid lipid nanoparticles for tissue repairing. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[10]  M. Jassal,et al.  Bi-layer composite dressing of gelatin nanofibrous mat and poly vinyl alcohol hydrogel for drug delivery and wound healing application: in-vitro and in-vivo studies. , 2013, Journal of biomedical nanotechnology.

[11]  S. T. Lee,et al.  Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing. , 2001, Biomaterials.

[12]  Praveen B. Kajjari,et al.  Novel blend microspheres of poly(vinyl alcohol) and succinyl chitosan for controlled release of nifedipine , 2013, Polymer Bulletin.

[13]  R. Muzzarelli.  Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone , 2009 .

[14]  H. Park,et al.  Preparation and biocompatibility of chitosan microcarriers as biomaterial , 2006 .

[15]  S. Moochhala,et al.  Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. , 2008, Biomaterials.

[16]  R. Ahvenainen,et al.  Chitosan disrupts the barrier properties of the outer membrane of gram-negative bacteria. , 2001, International journal of food microbiology.

[17]  Seyed Hassan Jafari,et al.  A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages , 2010 .

[18]  Tao Wang,et al.  Hydrogel sheets of chitosan, honey and gelatin as burn wound dressings , 2012 .

[19]  M. Morimoto,et al.  Chemical modification of chitin and chitosan 1: preparation of partially deacetylated chitin derivatives via a ring-opening reaction with cyclic acid anhydrides in lithium chloride/N,N-dimethylacetamide , 1999 .

[20]  Ming Kong,et al.  Antibacterial mechanism of chitosan microspheres in a solid dispersing system against E. coli. , 2008, Colloids and surfaces. B, Biointerfaces.

[21]  C. Jérôme,et al.  Chitosan-based biomaterials for tissue engineering , 2013 .

[22]  T. Trindade,et al.  Antibacterial activity of optically transparent nanocomposite films based on chitosan or its derivatives and silver nanoparticles. , 2012, Carbohydrate research.

[23]  L. FRAS ZEMLJIČ,et al.  Characterization of Amino Groups for Cotton Fibers Coated with Chitosan , 2009 .

[24]  Weilin Xu,et al.  Potential of quaternization-functionalized chitosan fiber for wound dressing. , 2013, International journal of biological macromolecules.

[25]  Y. Kato,et al.  N-succinyl-chitosan as a drug carrier: water-insoluble and water-soluble conjugates. , 2004, Biomaterials.

[26]  Tao Huang,et al.  Bubble template fabrication of chitosan/poly(vinyl alcohol) sponges for wound dressing applications. , 2013, International journal of biological macromolecules.

[27]  Toshio Yoshimura,et al.  Synthesis and characterization of novel biodegradable superabsorbent hydrogels based on chitin and succinic anhydride , 2005 .

[28]  Hua Zheng,et al.  Preparation and anticoagulant activity of N-succinyl chitosan sulfates. , 2012, International journal of biological macromolecules.

[29]  H E Junginger,et al.  Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[30]  L. Yi,et al.  Biological properties of the chitosan-gelatin sponge wound dressing , 2007 .

[31]  H. C. de Sousa,et al.  Chitosan-based dressings loaded with neurotensin--an efficient strategy to improve early diabetic wound healing. , 2014, Acta biomaterialia.