The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation.

[1]  S. Bultman,et al.  Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression , 2012, Journal of cellular physiology.

[2]  B. Corfe.  Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation. , 2012, Molecular bioSystems.

[3]  S. Berger,et al.  IDH mutation impairs histone demethylation and results in a block to cell differentiation , 2012, Nature.

[4]  Peter A. Jones,et al.  A decade of exploring the cancer epigenome — biological and translational implications , 2011, Nature Reviews Cancer.

[5]  Liping Zhao,et al.  Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers , 2011, The ISME Journal.

[6]  D. Baltimore,et al.  Anti-apoptotic effect of hyperglycemia can allow survival of potentially autoreactive T cells , 2011, Cell Death and Differentiation.

[7]  Kun-Liang Guan,et al.  Regulation of intermediary metabolism by protein acetylation. , 2011, Trends in biochemical sciences.

[8]  Bin Wang,et al.  Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. , 2011, Cancer cell.

[9]  Qi-jing Wang,et al.  Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene , 2010, Molecular Cancer.

[10]  Yixue Li,et al.  Regulation of Cellular Metabolism by Protein Lysine Acetylation , 2010, Science.

[11]  G. Semenza,et al.  Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression , 2010, Proceedings of the National Academy of Sciences.

[12]  Justin R. Cross,et al.  ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation , 2009, Science.

[13]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[14]  Daniel Monleón,et al.  Metabolite profiling of fecal water extracts from human colorectal cancer , 2009, NMR in biomedicine.

[15]  C. Chaumontet,et al.  Butyrate metabolism in human colon carcinoma cells: Implications concerning its growth‐inhibitory effect , 2009, Journal of cellular physiology.

[16]  B. Ramakrishna,et al.  Real‐time polymerase chain reaction quantification of specific butyrate‐producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer , 2008, Journal of gastroenterology and hepatology.

[17]  J. Davie,et al.  Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. , 2007, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[18]  J. Milner,et al.  Dietary modulation of colon cancer risk. , 2007, The Journal of nutrition.

[19]  D. Jonkers,et al.  Review article: the role of butyrate on colonic function , 2007, Alimentary pharmacology & therapeutics.

[20]  M. Comalada,et al.  The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype , 2006, Journal of Cancer Research and Clinical Oncology.

[21]  P. Gibson,et al.  Does butyrate protect from colorectal cancer? , 2006, Journal of gastroenterology and hepatology.

[22]  F. Bornet,et al.  Effects of a 3-mo Consumption of Short-Chain Fructo-Oligosaccharides on Parameters of Colorectal Carcinogenesis in Patients With or Without Small or Large Colorectal Adenomas , 2005, Nutrition and cancer.

[23]  C. Croce,et al.  Knockout mice reveal a tumor suppressor function for Testin. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[24]  George A Calin,et al.  Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[25]  W. Scheppach,et al.  The butyrate story: old wine in new bottles? , 2004, Current opinion in clinical nutrition and metabolic care.

[26]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[27]  J. Lupton.  Microbial degradation products influence colon cancer risk: the butyrate controversy. , 2004, The Journal of nutrition.

[28]  Xiang-Jiao Yang.  The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. , 2004, Nucleic acids research.

[29]  J. Davie.  Inhibition of histone deacetylase activity by butyrate. , 2003, The Journal of nutrition.

[30]  J. Tavaré,et al.  The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes* , 2002, The Journal of Biological Chemistry.

[31]  R. Toillon,et al.  Sodium butyrate induces P53‐independent, Fas‐mediated apoptosis in MCF‐7 human breast cancer cells , 2002, British journal of pharmacology.

[32]  W. Sessa,et al.  Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[33]  S. Horinouchi,et al.  Radicicol Binds and Inhibits Mammalian ATP Citrate Lyase* , 2000, The Journal of Biological Chemistry.

[34]  H. Blottière,et al.  Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells. , 2000, European journal of biochemistry.

[35]  K. Mimori,et al.  Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. , 2000, Genomics.

[36]  J. Clark,et al.  Cloning and characterization of a novel human histone deacetylase, HDAC8. , 2000, The Biochemical journal.

[37]  P. Pouillart,et al.  Role of butyric acid and its derivatives in the treatment of colorectal cancer and hemoglobinopathies. , 1998, Life sciences.

[38]  S. Meng,et al.  p21WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells , 1998 .

[39]  C. Paraskeva,et al.  Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources. , 1997, Carcinogenesis.

[40]  O. Velazquez,et al.  Deoxycholate inhibits in vivo butyrate-mediated BrDU labeling of the colonic crypt. , 1997, The Journal of surgical research.

[41]  F. Bornet,et al.  Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. , 1997, Cancer research.

[42]  A. Csordás.  Butyrate, aspirin and colorectal cancer. , 1996, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[43]  L. Augenlicht,et al.  Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[44]  T. Kirchner,et al.  Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. , 1992, Gastroenterology.

[45]  M. L. Liu,et al.  Nutrient utilization by cells isolated from rat jejunum, cecum and colon. , 1991, The Journal of nutrition.

[46]  G. Macfarlane,et al.  Short chain fatty acids in human large intestine, portal, hepatic and venous blood. , 1987, Gut.

[47]  E. Kurschel,et al.  Clinical pharmacology of sodium butyrate in patients with acute leukemia. , 1987, European journal of cancer & clinical oncology.

[48]  J. Jass.  Diet, butyric acid and differentiation of gastrointestinal tract tumours. , 1985, Medical hypotheses.

[49]  D. Chopra,et al.  Primary and long term epithelial cell cultures from human fetal normal colonic mucosa , 1984, In Vitro.

[50]  W. Roediger.  Utilization of nutrients by isolated epithelial cells of the rat colon. , 1982, Gastroenterology.

[51]  B. Fleshler,et al.  Physiology of the Gastrointestinal Tract , 1969 .

[52]  J. Uhm.  IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype , 2012 .

[53]  Peter A. Jones,et al.  Epigenetics in cancer. , 2010, Carcinogenesis.

[54]  S. Meng,et al.  p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[55]  A. Paerregaard.  [Gastrointestinal mucus]. , 1996, Ugeskrift for laeger.