High prevalence of low-allele-fraction somatic mutations in STAT3 in peripheral blood CD8+ cells in multiple sclerosis patients and controls
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S. Mustjoki | S. Lundgren | P. Tienari | Lilja Jansson | M. Valori | Jonna Clancy | Joonas Lehikoinen
[1] David A. Alagpulinsa,et al. Advances in understanding the molecular basis of clonal hematopoiesis. , 2022, Trends in molecular medicine.
[2] S. Elledge,et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis , 2022, Science.
[3] P. Tienari,et al. CD8+ cell somatic mutations in multiple sclerosis patients and controls—Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies , 2021, PloS one.
[4] S. Mustjoki,et al. Somatic STAT3 mutations in CD8+ T cells of healthy blood donors carrying human T-cell leukemia virus type 2 , 2021, Haematologica.
[5] B. Ebert,et al. Distinction of lymphoid and myeloid clonal hematopoiesis , 2021, Nature Medicine.
[6] T. Olsson,et al. Association of Infectious Mononucleosis in Childhood and Adolescence With Risk for a Subsequent Multiple Sclerosis Diagnosis Among Siblings , 2021, JAMA network open.
[7] P. Campbell,et al. The longitudinal dynamics and natural history of clonal haematopoiesis , 2021, Nature.
[8] M. Stratton,et al. Somatic mutation landscapes at single-molecule resolution , 2021, Nature.
[9] H. Lähdesmäki,et al. Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia , 2021, Leukemia.
[10] B. Baradaran,et al. Ruxolitinib attenuates experimental autoimmune encephalomyelitis (EAE) development as animal models of multiple sclerosis (MS). , 2021, Life sciences.
[11] D. Goodin,et al. The nature of genetic and environmental susceptibility to multiple sclerosis , 2021, PloS one.
[12] Yuhong Yang,et al. A STAT3 inhibitor ameliorates CNS autoimmunity by restoring Teff:Treg balance , 2021, JCI insight.
[13] J. Mullikin,et al. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease. , 2020, The New England journal of medicine.
[14] J. Partanen,et al. Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort , 2020, NAR genomics and bioinformatics.
[15] Zhongming Zhao,et al. Dense module searching for gene networks associated with multiple sclerosis , 2020, BMC Medical Genomics.
[16] Yuchen Yuan,et al. Systematic comparison of somatic variant calling performance among different sequencing depth and mutation frequency , 2020, Scientific Reports.
[17] Timothy J. Peters,et al. Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody , 2020, Cell.
[18] B. Serafini,et al. Epstein-Barr Virus-Specific CD8 T Cells Selectively Infiltrate the Brain in Multiple Sclerosis and Interact Locally with Virus-Infected Cells: Clue for a Virus-Driven Immunopathological Mechanism , 2019, Journal of Virology.
[19] Simon C. Potter,et al. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility , 2019, Science.
[20] Krishna R. Kalari,et al. Cell-level somatic mutation detection from single-cell RNA sequencing , 2019, Bioinform..
[21] Jesse J. Salk,et al. Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations , 2018, Nature Reviews Genetics.
[22] S. Mustjoki,et al. Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia , 2017, Haematologica.
[23] Mauricio O. Carneiro,et al. Scaling accurate genetic variant discovery to tens of thousands of samples , 2017, bioRxiv.
[24] W. Chan,et al. Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling , 2017, Oncotarget.
[25] Brent S. Pedersen,et al. Mosdepth: quick coverage calculation for genomes and exomes , 2017, bioRxiv.
[26] S. Mustjoki,et al. Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis , 2017, Nature Communications.
[27] Sarah Sandmann,et al. Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data , 2017, Scientific Reports.
[28] S. Mustjoki,et al. A novel class of somatic mutations in blood detected preferentially in CD8 + cells , 2017, Clinical immunology.
[29] B. Gold. Somatic mutations in cancer: Stochastic versus predictable. , 2017, Mutation research.
[30] Vladimir Potapov,et al. Examining Sources of Error in PCR by Single-Molecule Sequencing , 2017, PloS one.
[31] L. Young,et al. Epstein–Barr virus: more than 50 years old and still providing surprises , 2016, Nature Reviews Cancer.
[32] T. Druley,et al. Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults , 2016, Nature Communications.
[33] J. Kere,et al. Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3. , 2015, Blood.
[34] C. Quince,et al. Insight into biases and sequencing errors for amplicon sequencing with the Illumina MiSeq platform , 2015, Nucleic acids research.
[35] S. Mustjoki,et al. The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia , 2015, Haematologica.
[36] Richard A. Olshen,et al. Diversity and clonal selection in the human T-cell repertoire , 2014, Proceedings of the National Academy of Sciences.
[37] J. Kere,et al. Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease , 2014, Nature Genetics.
[38] S. Mustjoki,et al. STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients. , 2013, Blood.
[39] M. Pirinen,et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis , 2013, Nature Genetics.
[40] Sandra D'Alfonso,et al. Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. , 2013, American journal of human genetics.
[41] Chester Ni,et al. In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6–Mediated Signaling , 2013, Science Translational Medicine.
[42] Steven M Holland,et al. JAKs and STATs in immunity, immunodeficiency, and cancer. , 2013, The New England journal of medicine.
[43] S. Mustjoki,et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. , 2012, The New England journal of medicine.
[44] S. Holland,et al. A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. , 2011, Immunity.
[45] J. B. Oliveira,et al. Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. , 2011, Blood.
[46] R. Marcos,et al. Mutation Research/Genetic Toxicology and Environmental Mutagenesis , 2011 .
[47] Ludwig Kappos,et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. , 2010, American journal of human genetics.
[48] W. Sheremata,et al. LGL leukemia and HTLV. , 2010, AIDS research and human retroviruses.
[49] Richard Durbin,et al. Sequence analysis Fast and accurate short read alignment with Burrows – Wheeler transform , 2009 .
[50] C. Goodnow. Multistep Pathogenesis of Autoimmune Disease , 2007, Cell.
[51] P. Tonali,et al. pSTAT1, pSTAT3, and T‐bet expression in peripheral blood mononuclear cells from relapsing‐remitting multiple sclerosis patients correlates with disease activity , 2006, Journal of neuroscience research.
[52] S. Vukusic,et al. Natural history of multiple sclerosis: a unifying concept. , 2006, Brain : a journal of neurology.
[53] Edmus Coordinating. Natural history of multiple sclerosis: A unifying concept , 2006 .
[54] F. Rieux-Laucat,et al. Autoimmune lymphoproliferative syndrome with somatic Fas mutations. , 2004, The New England journal of medicine.
[55] G. Comi,et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. , 1997, Brain : a journal of neurology.
[56] S. Sriram. Longitudinal study of frequency of HPRT mutant T cells in patients with multiple sclerosis , 1994, Neurology.
[57] J. Partanen,et al. AN HLA‐DR TYPING PROTOCOL USING GROUP‐SPECIFIC PCR‐AMPLIFICATION FOLLOWED BY RESTRICTION ENZYME DIGESTS , 1993, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.
[58] R J Albertini,et al. T cells responsive to myelin basic protein in patients with multiple sclerosis. , 1990, Science.
[59] M. Burnet. Somatic Mutation and Chronic Disease* , 1965, British medical journal.