We have successfully developed a unique multiple-jet electrospinning technology at STAR, Inc. and Stony Brook University. The development of this technology was primarily accomplished by the incorporation of secondary electrodes to isolate the electric field distribution of the primary electrode spinnerets, the design of an individual fluid distribution system and the optimization of system design using the finite element analysis method, in combination with experimental tests. The key technological advance permits the small-scale mass fabrication of membranes with composite nanofiber/ nanoparticle hybrid morphology, tailor-designed composition variations, and 3D pattern formation from polymer solutions.