Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

[1]  J. Locasale,et al.  Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism , 2018, Cell reports.

[2]  A. Limper,et al.  Fatty acid synthase is required for profibrotic TGF‐β signaling , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  S. Rafii,et al.  Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis , 2017, Science Translational Medicine.

[4]  Robert W. Williams,et al.  Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals , 2017, The Journal of cell biology.

[5]  S. Keshavjee,et al.  Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic study , 2017, BMJ Open Respiratory Research.

[6]  A. Anzueto,et al.  Effectiveness and safety of mycophenolate mofetil in idiopathic pulmonary fibrosis , 2017, PloS one.

[7]  J. Gilhodes,et al.  Quantification of Pulmonary Fibrosis in a Bleomycin Mouse Model Using Automated Histological Image Analysis , 2017, PloS one.

[8]  B. Stripp,et al.  Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. , 2016, JCI insight.

[9]  D. Nomura,et al.  Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response , 2016, Cell.

[10]  Cole M. Haynes,et al.  The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR , 2016, Current Biology.

[11]  P. Neufer,et al.  Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria , 2016, Trends in Endocrinology & Metabolism.

[12]  B. Mesmin.  Mitochondrial lipid transport and biosynthesis: A complex balance , 2016, The Journal of cell biology.

[13]  A. Ryan,et al.  Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. , 2016, Immunity.

[14]  J. Asara,et al.  mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle , 2016, Science.

[15]  K. Vousden,et al.  Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells , 2016, Molecular cell.

[16]  F. Polleux,et al.  AMP-activated protein kinase mediates mitochondrial fission in response to energy stress , 2016, Science.

[17]  Y. Yoo,et al.  Measuring In Vivo Mitophagy. , 2015, Molecular cell.

[18]  S. Agarwal,et al.  Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity , 2015, Nature Communications.

[19]  J. Burman,et al.  The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy , 2015, Nature.

[20]  M. Blasco,et al.  Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction. , 2015, Cell reports.

[21]  A. Choi,et al.  Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis , 2015, PloS one.

[22]  L. Scorrano,et al.  Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. , 2015, Cell metabolism.

[23]  Janet S. Lee,et al.  PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. , 2015, The Journal of clinical investigation.

[24]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[25]  D. Link,et al.  Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. , 2015, Cell metabolism.

[26]  Yu Xue,et al.  HemI: A Toolkit for Illustrating Heatmaps , 2014, PloS one.

[27]  Ke Zhang,et al.  Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production , 2014, eLife.

[28]  T. Geiser,et al.  Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis , 2014, Scientific Reports.

[29]  M. Selman,et al.  Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model. , 2014, American journal of respiratory and critical care medicine.

[30]  N. Neff,et al.  Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq , 2014, Nature.

[31]  T. Bigby,et al.  Endotracheal intubation in mice via direct laryngoscopy using an otoscope. , 2014, Journal of visualized experiments : JoVE.

[32]  Prashant Mishra,et al.  Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. , 2014, Cell metabolism.

[33]  M. Krasnow,et al.  Alveolar progenitor and stem cells in lung development, renewal and cancer , 2014, Nature.

[34]  M. Syamsunarno,et al.  Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice , 2013, Nature Communications.

[35]  M. Dietrich,et al.  Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance , 2013, Cell.

[36]  S. Small,et al.  Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system , 2013, Nature Communications.

[37]  Michael J. Cronce,et al.  Type 2 alveolar cells are stem cells in adult lung. , 2013, The Journal of clinical investigation.

[38]  G. Dorn,et al.  PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria , 2013, Science.

[39]  Cole Trapnell,et al.  TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions , 2013, Genome Biology.

[40]  David G Hendrickson,et al.  Differential analysis of gene regulation at transcript resolution with RNA-seq , 2012, Nature Biotechnology.

[41]  R. Mason,et al.  Efficient and rapid isolation and purification of mouse alveolar type II epithelial cells , 2012, Experimental lung research.

[42]  Xianhua Wang,et al.  Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes* , 2012, The Journal of Biological Chemistry.

[43]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[44]  Markus R Wenk,et al.  Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease* , 2011, The Journal of Biological Chemistry.

[45]  Michael J. Cronce,et al.  Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition , 2011, Proceedings of the National Academy of Sciences.

[46]  Atsushi Miyawaki,et al.  A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. , 2011, Chemistry & biology.

[47]  E. Schleicher,et al.  Increased palmitoyl-myristoyl-phosphatidylcholine in neonatal rat surfactant is lung specific and correlates with oral myristic acid supply. , 2011, Journal of applied physiology.

[48]  Gary D Bader,et al.  Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation , 2010, PloS one.

[49]  R. Homer,et al.  Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. , 2010, The Journal of clinical investigation.

[50]  J. Bridges,et al.  LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. , 2010, The Journal of clinical investigation.

[51]  S. Salzberg,et al.  Transcript assembly and abundance estimation from RNA-Seq reveals thousands of new transcripts and switching among isoforms , 2010, Nature Biotechnology.

[52]  T. Prolla,et al.  Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations , 2010, Cell.

[53]  J. Whitsett,et al.  Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. , 2010, Annual review of medicine.

[54]  Allan R. Jones,et al.  A robust and high-throughput Cre reporting and characterization system for the whole mouse brain , 2009, Nature Neuroscience.

[55]  L. Scorrano,et al.  Mitofusin 2 tethers endoplasmic reticulum to mitochondria , 2008, Nature.

[56]  D. Chan,et al.  OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L , 2007, The Journal of cell biology.

[57]  J. McCaffery,et al.  Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum , 2007, Cell.

[58]  S. Young,et al.  Early Embryonic Lethality Caused by Disruption of the Gene for Choline Kinase α, the First Enzyme in Phosphatidylcholine Biosynthesis* , 2007, Journal of Biological Chemistry.

[59]  J. Rehg,et al.  Role of Phosphocholine Cytidylyltransferase α in Lung Development , 2006, Molecular and Cellular Biology.

[60]  Tiejuan Mi,et al.  Adenosine-Dependent Pulmonary Fibrosis in Adenosine Deaminase-Deficient Mice1 , 2005, The Journal of Immunology.

[61]  T. D. Pugh,et al.  Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging , 2005, Science.

[62]  Howard T. Jacobs,et al.  Premature ageing in mice expressing defective mitochondrial DNA polymerase , 2004, Nature.

[63]  Erik E. Griffin,et al.  Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development , 2003, The Journal of cell biology.

[64]  G. Izbicki,et al.  Time course of bleomycin‐induced lung fibrosis , 2002, International journal of experimental pathology.

[65]  Heinz Fehrenbach,et al.  Alveolar epithelial type II cell: defender of the alveolus revisited , 2001, Respiratory research.

[66]  J. Crapo,et al.  Allometric relationships of cell numbers and size in the mammalian lung. , 1992, American journal of respiratory cell and molecular biology.

[67]  T. King,et al.  Idiopathic pulmonary fibrosis. Abnormalities in bronchoalveolar lavage fluid phospholipids. , 1988, The American review of respiratory disease.

[68]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[69]  J. Rehg,et al.  Role of phosphocholine cytidylyltransferase alpha in lung development. , 2007, Molecular and cellular biology.

[70]  Edinburgh Research Explorer Idiopathic Pulmonary Fibrosis , 2022 .