Too large to fit? Recent developments in macromolecular imprinting.

Molecular imprinting involves the synthesis of polymers in the presence of a template to produce complementary binding sites with specific recognition ability. The technique has been successfully applied as a measurement and separation technology, producing a uniquely robust and antibody-like polymeric material. Low molecular weight molecules have been extensively exploited as imprint templates, leading to significant achievements in solid-phase extraction, sensing and enzyme-like catalysis. By contrast, macromolecular imprinting remains underdeveloped, principally because of the lack of binding site accessibility. In this review, we focus on the most recent developments in this area, not only covering the widespread use of biological macro-templates but also highlighting the emerging use of synthetic macro-templates, such as dendrimers and hyperbranched polymers.

[1]  Boris Mizaikoff,et al.  Capturing molecules with templated materials--analysis and rational design of molecularly imprinted polymers. , 2006, Analytica chimica acta.

[2]  Tse-Chuan Chou,et al.  Using protein templates to direct the formation of thin-film polymer surfaces. , 2006, Biosensors & bioelectronics.

[3]  T. Guo,et al.  Adsorptive separation of hemoglobin by molecularly imprinted chitosan beads. , 2004, Biomaterials.

[4]  Donald A Tomalia,et al.  Dendrimers in biomedical applications--reflections on the field. , 2005, Advanced drug delivery reviews.

[5]  Tse-Chuan Chou,et al.  Polyacrylamide gels with electrostatic functional groups for the molecular imprinting of lysozyme , 2004 .

[6]  Xiaoguang Ying,et al.  Emulsion and macromolecules templated alginate based polymer microspheres , 2006 .

[7]  Hu Yang,et al.  Dendrimers for pharmaceutical and biomedical applications , 2006, Journal of biomaterials science. Polymer edition.

[8]  M. Márquez,et al.  Facile sol-gel synthesis of porous silicas using poly(propylene)imine dendrimers as templates , 2000 .

[9]  Boris Mizaikoff,et al.  Molecularly imprinted polymers—potential and challenges in analytical chemistry , 2005, Analytica Chimica Acta.

[10]  G. Cheng,et al.  Bovine serum albumin-imprinted polyacrylamide gel beads prepared via inverse-phase seed suspension polymerization , 2005 .

[11]  J. Z. Hilt,et al.  Configurational biomimesis in drug delivery: molecular imprinting of biologically significant molecules. , 2004, Advanced drug delivery reviews.

[12]  D. Yan,et al.  Hyperbranched polymers: from synthesis to applications , 2004 .

[13]  A. Turner,et al.  Molecularly imprinted polymers for the recognition of proteins: the state of the art. , 2007, Biosensors & bioelectronics.

[14]  Franz L. Dickert,et al.  Mass-sensitive detection of cells, viruses and enzymes with artificial receptors , 2003 .

[15]  Nicholas W Turner,et al.  From 3D to 2D: A Review of the Molecular Imprinting of Proteins , 2006, Biotechnology progress.

[16]  G. Cheng,et al.  Synthesis of polyacrylamide gel beads with electrostatic functional groups for the molecular imprinting of bovine serum albumin , 2006, Analytical and bioanalytical chemistry.

[17]  Olof Ramström,et al.  Molecularly Imprinted Materials : Science and Technology , 2004 .

[18]  G. Ciardelli,et al.  Molecularly imprinted membranes for an improved recognition of biomolecules in aqueous medium , 2006 .

[19]  K. Mosbach,et al.  The Use of Immobilized Templates-A New Approach in Molecular Imprinting. , 2000, Angewandte Chemie.

[20]  Karsten Haupt,et al.  Molecularly imprinted polymers: the next generation. , 2003, Analytical chemistry.

[21]  Stellan Hjertén,et al.  Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria): II. Gel antibodies against virus (Semliki Forest Virus). , 2006, Journal of separation science.

[22]  B. Sellergren,et al.  Improved imide receptors by imprinting using pyrimidine-based fluorescent reporter monomers. , 2005, The Journal of organic chemistry.

[23]  Nicholas W Turner,et al.  Formation of protein molecular imprints within Langmuir monolayers: a quartz crystal microbalance study. , 2007, Journal of colloid and interface science.

[24]  G. Cheng,et al.  Soft-wet polyacrylamide gel beads with the imprinting of bovine serum albumin , 2006 .

[25]  Steven C Zimmerman,et al.  Synthetic hosts via molecular imprinting--are universal synthetic antibodies realistically possible? , 2004, Chemical communications.

[26]  Börje Sellergren,et al.  A stoichiometric molecularly imprinted polymer for the class-selective recognition of antibiotics in aqueous media. , 2006, Angewandte Chemie.

[27]  A. Rachkov,et al.  Towards molecularly imprinted polymers selective to peptides and proteins. The epitope approach. , 2001, Biochimica et biophysica acta.

[28]  Börje Sellergren,et al.  Urea host monomers for stoichiometric molecular imprinting of oxyanions. , 2005, The Journal of organic chemistry.

[29]  W. Hayes,et al.  Synthesis and applications of hyperbranched polymers , 2004 .

[30]  Zhaohui Zhang,et al.  Molecularly imprinted thin film self-assembled on piezoelectric quartz crystal surface by the sol-gel process for protein recognition. , 2006, Biosensors & bioelectronics.

[31]  T. Guo,et al.  Hemoglobin recognition by imprinting in semi-interpenetrating polymer network hydrogel based on polyacrylamide and chitosan. , 2005, Biomacromolecules.

[32]  Sandra E. Noriega,et al.  Dendrimer-mediated formation of Cu–CuOx nanoparticles on silica and their physical and catalytic characterization , 2004 .

[33]  A. Denizli,et al.  Molecular imprinted particles for lysozyme purification , 2007 .

[34]  A. Denizli,et al.  L-histidine imprinted synthetic receptor for biochromatography applications. , 2006, Analytical chemistry.

[35]  Jitao Huang,et al.  Template imprinting amphoteric polymer for the recognition of proteins , 2005 .

[36]  G. Cheng,et al.  Protein-imprinted soft-wet gel composite microspheres with magnetic susceptibility. II. Characteristics , 2006 .

[37]  Tse-Chuan Chou,et al.  The microcontact imprinting of proteins: the effect of cross-linking monomers for lysozyme, ribonuclease A and myoglobin. , 2006, Biosensors & bioelectronics.

[38]  Olof Ramström,et al.  Molecular imprinting technology: challenges and prospects for the future , 1998 .

[39]  L. Twyman,et al.  Porphyrin cored hyperbranched polymers as heme protein models. , 2006, Chemical communications.

[40]  Fujio Mizukami,et al.  A method for the molecular imprinting of hemoglobin on silica surfaces using silanes. , 2005, Biomaterials.

[41]  Frank V Bright,et al.  Templated xerogels as platforms for biomolecule-less biomolecule sensors. , 2006, Analytica chimica acta.

[42]  Brett A. Helms,et al.  Dendrimers at Work , 2006, Science.

[43]  Derek Stevenson,et al.  Quantification and confocal imaging of protein specific molecularly imprinted polymers. , 2006, Biomacromolecules.

[44]  A. Turner,et al.  Surface-grafted molecularly imprinted polymers for protein recognition. , 2001, Analytical chemistry.

[45]  Yong Li,et al.  Protein recognition via surface molecularly imprinted polymer nanowires. , 2006, Analytical chemistry.

[46]  D. Venton,et al.  Entrapment of enzymes using organo-functionalized polysiloxane copolymers. , 1995, Biochimica et biophysica acta.

[47]  Maria-Magdalena Titirici,et al.  Hierarchical Imprinting Using Crude Solid Phase Peptide Synthesis Products as Templates , 2003 .

[48]  M. H. Irfan,et al.  Chemistry of polymers , 1998 .

[49]  P. Manesiotis,et al.  Non-covalent imprinting of phosphorous esters , 2005 .

[50]  Ákos Végvári,et al.  Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses and cells (bacteria). Ib. Gel antibodies against proteins (hemoglobins) , 2006, Electrophoresis.

[51]  A. Rachkov,et al.  Molecularly imprinted polymers prepared in aqueous solution selective for [ Sar 1 , Ala 8 ] angiotensin II , 2003 .

[52]  Maria-Magdalena Titirici,et al.  Hierarchically Imprinted Stationary Phases: Mesoporous Polymer Beads Containing Surface-Confined Binding Sites for Adenine , 2002 .

[53]  Peter A. Lieberzeit,et al.  Artificial Antibodies for Bioanalyte Detection—Sensing Viruses and Proteins , 2006 .

[54]  K. Shea,et al.  Selective protein capture by epitope imprinting. , 2006, Angewandte Chemie.

[55]  D L Venton,et al.  Influence of protein on polysiloxane polymer formation: evidence for induction of complementary protein-polymer interactions. , 1995, Biochimica et biophysica acta.

[56]  A. Rachkov,et al.  Molecularly imprinted polymers prepared in aqueous solution selective for [Sar1,Ala8]angiotensin II , 2004 .

[57]  Neal A. Rakow,et al.  Synthetic hosts by monomolecular imprinting inside dendrimers , 2002, Nature.

[58]  S. Zimmerman,et al.  Cross-linked dendrimer hosts containing reporter groups for amine guests. , 2003, Journal of the American Chemical Society.

[59]  Imprinting unique motifs formed from protein–protein associations , 2005 .

[60]  F. Dickert,et al.  Bioimprinting of polymers and sol-gel phases. Selective detection of yeasts with imprinted polymers. , 2002, Analytical chemistry.

[61]  Sergey A. Piletsky,et al.  Molecular Imprinting of Polymers , 2006 .