Nitric oxide synthases in heart failure.
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[1] K. Andrews,et al. Arginase II inhibition prevents nitrate tolerance , 2012, British journal of pharmacology.
[2] J. Jang,et al. Neuronal nitric oxide synthase is up-regulated by angiotensin II and attenuates NADPH oxidase activity and facilitates relaxation in murine left ventricular myocytes. , 2012, Journal of molecular and cellular cardiology.
[3] U. Laufs,et al. Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis. , 2012, Cardiovascular research.
[4] D. Kass,et al. Preconditioning by Phosphodiesterase‐5 Inhibition Improves Therapeutic Efficacy of Adipose‐Derived Stem Cells Following Myocardial Infarction in Mice , 2012, Stem cells.
[5] P. Vardas,et al. Effects of the long‐term administration of nebivolol on the clinical symptoms, exercise capacity, and left ventricular function of patients with diastolic dysfunction: results of the ELANDD study , 2012, European journal of heart failure.
[6] D. Kass,et al. Pressure-Overload–Induced Subcellular Relocalization/Oxidation of Soluble Guanylyl Cyclase in the Heart Modulates Enzyme Stimulation , 2012, Circulation research.
[7] K. Channon,et al. Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. , 2012, Journal of the American College of Cardiology.
[8] A. Alkilany,et al. Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway , 2012, British journal of pharmacology.
[9] S. Jha,et al. Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation. , 2011, Journal of the American College of Cardiology.
[10] J. Stamler,et al. Regulation by S-Nitrosylation of Protein Post-translational Modification* , 2011, The Journal of Biological Chemistry.
[11] M. Whiteman,et al. Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. , 2011, Clinical science.
[12] P. Eaton,et al. Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension , 2011, Nature Medicine.
[13] T. Iwasaka,et al. Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. , 2011, American journal of physiology. Heart and circulatory physiology.
[14] X. Tian,et al. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. , 2011, Cardiovascular research.
[15] P. Mehta,et al. Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II. , 2011, Cardiovascular research.
[16] D. Kass,et al. Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure. , 2011, Journal of molecular and cellular cardiology.
[17] D. Kass,et al. Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin. , 2011, Journal of molecular and cellular cardiology.
[18] M. Bonini,et al. NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses. , 2011, European journal of pharmacology.
[19] M. Kavdia,et al. Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production. , 2011, Free radical biology & medicine.
[20] Hang Lu,et al. Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress , 2011, Heart.
[21] A. Banday,et al. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. , 2011, European journal of pharmacology.
[22] Michael D. Pluth,et al. Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis , 2011, Proceedings of the National Academy of Sciences.
[23] U. Schotten,et al. Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation: Implications for the Antiarrhythmic Effect of Statins , 2011, Circulation.
[24] Arthur J. L. Cooper,et al. Reversible and irreversible protein glutathionylation: biological and clinical aspects , 2011, Expert opinion on drug metabolism & toxicology.
[25] J. Zweier,et al. Superoxide Induces Endothelial Nitric-oxide Synthase Protein Thiyl Radical Formation, a Novel Mechanism Regulating eNOS Function and Coupling* , 2011, The Journal of Biological Chemistry.
[26] A. Hale,et al. Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency , 2011, Free radical biology & medicine.
[27] P. Insel,et al. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. , 2011, Journal of the American College of Cardiology.
[28] J. Cheung,et al. Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3. , 2011, Journal of cardiac failure.
[29] M. W. Vogel,et al. Novel Natriuretic Peptides: New Compounds and New Approaches , 2011, Current heart failure reports.
[30] M. Gucek,et al. Simultaneous Measurement of Protein Oxidation and S-Nitrosylation During Preconditioning and Ischemia/Reperfusion Injury With Resin-Assisted Capture , 2011, Circulation research.
[31] D. Julian,et al. Hydrogen Sulfide Increases Nitric Oxide Production from Endothelial Cells by an Akt-Dependent Mechanism , 2011, Front. Physio..
[32] J. Balligand,et al. Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional β1-blockade. , 2011, Journal of the American College of Cardiology.
[33] R. Arena,et al. PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure: Results of a 1-Year, Prospective, Randomized, Placebo-Controlled Study , 2011, Circulation. Heart failure.
[34] Saisudha Koka,et al. Attenuation of Doxorubicin-induced Cardiotoxicity by Tadalafil: A Long Acting Phosphodiesterase-5 Inhibitor. , 2010, Molecular and cellular pharmacology.
[35] J. Zweier,et al. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function , 2010, Nature.
[36] W. Paulus,et al. The role of asymmetric dimethylarginine and arginine in the failing heart and its vasculature , 2010, European journal of heart failure.
[37] P. Nordbeck,et al. Conditional Overexpression of Neuronal Nitric Oxide Synthase Is Cardioprotective in Ischemia/Reperfusion , 2010, Circulation.
[38] J. Beavo,et al. Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy , 2010, Proceedings of the National Academy of Sciences.
[39] G. Nasr,et al. Allopurinol and global left myocardial function in heart failure patients , 2010, Journal of cardiovascular disease research.
[40] U. Förstermann,et al. Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice , 2010, Journal of Pharmacology and Experimental Therapeutics.
[41] J. Corbin,et al. cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action , 2010, Pharmacological Reviews.
[42] S. Viatchenko‐Karpinski,et al. Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S‐nitrosylation , 2010, The Journal of physiology.
[43] N. Stergiopulos,et al. Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension. , 2010, Cardiovascular research.
[44] F. Grimminger,et al. Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study , 2010, European Respiratory Journal.
[45] J. Pearson. Endothelial progenitor cells--an evolving story. , 2010, Microvascular research.
[46] Paul L Huang,et al. Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle. , 2010, The Journal of clinical investigation.
[47] S. Dikalov,et al. Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction , 2010, Circulation.
[48] F. Sotgia,et al. Caveolinopathies: from the biology of caveolin-3 to human diseases , 2010, European Journal of Human Genetics.
[49] Dong I. Lee,et al. PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation , 2010, Basic Research in Cardiology.
[50] J. Hare,et al. Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON. , 2009, Nitric oxide : biology and chemistry.
[51] M. Crabtree,et al. Dihydrofolate reductase and biopterin recycling in cardiovascular disease. , 2009, Journal of molecular and cellular cardiology.
[52] Douglas L. Jones,et al. Neuronal Nitric Oxide Synthase Protects Against Myocardial Infarction–Induced Ventricular Arrhythmia and Mortality in Mice , 2009, Circulation.
[53] A. Shoukas,et al. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. , 2009, Journal of applied physiology.
[54] J. Stamler,et al. Protein S-nitrosylation in health and disease: a current perspective. , 2009, Trends in molecular medicine.
[55] F. Atienza,et al. Nitric Oxide Increases Cardiac IK1 by Nitrosylation of Cysteine 76 of Kir2.1 Channels , 2009, Circulation research.
[56] Mark J. Kohr,et al. Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. , 2009, Journal of molecular and cellular cardiology.
[57] Jun Zhang,et al. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. , 2009, American journal of physiology. Heart and circulatory physiology.
[58] H. Otani. The role of nitric oxide in myocardial repair and remodeling. , 2009, Antioxidants & redox signaling.
[59] A. Shah,et al. Effects of Neuronal Nitric Oxide Synthase on Human Coronary Artery Diameter and Blood Flow In Vivo , 2009, Circulation.
[60] B. Levy,et al. Tetrahydrobiopterin Recycling, a Key Determinant of Endothelial Nitric-oxide Synthase-dependent Signaling Pathways in Cultured Vascular Endothelial Cells* , 2009, Journal of Biological Chemistry.
[61] Dimitris Tousoulis,et al. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. , 2009, European heart journal.
[62] J. Stamler,et al. Endogenous S-nitrosothiols protect against myocardial injury , 2009, Proceedings of the National Academy of Sciences.
[63] T. Rea,et al. Genetic Variations in Nitric Oxide Synthase 1 Adaptor Protein Are Associated With Sudden Cardiac Death in US White Community-Based Populations , 2009, Circulation.
[64] B. Mayer,et al. Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: lack of evidence for a role in the bioactivation of nitroglycerin. , 2009, Nitric oxide : biology and chemistry.
[65] D. Kass,et al. Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload. , 2009, Journal of the American College of Cardiology.
[66] A. Hale,et al. Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status , 2009, Journal of Biological Chemistry.
[67] D. Paterson,et al. Neuromodulators of peripheral cardiac sympatho‐vagal balance , 2009, Experimental physiology.
[68] J. Tamargo,et al. Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1). , 2008, Cardiovascular research.
[69] G. Wensing,et al. Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of the Soluble Guanylate Cyclase Activator Cinaciguat (BAY 58‐2667) in Healthy Male Volunteers , 2008, Journal of clinical pharmacology.
[70] J. Zweier,et al. Cardiac Myocyte–Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition , 2008, Circulation.
[71] J. Vasquez-Vivar,et al. Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. , 2008, American journal of physiology. Heart and circulatory physiology.
[72] H. Shimokawa,et al. Spontaneous myocardial infarction and nitric oxide synthase. , 2008, Trends in cardiovascular medicine.
[73] D. Christianson,et al. Arginase and vascular aging. , 2008, Journal of applied physiology.
[74] J. Zweier,et al. Phosphorylation of Endothelial Nitric-oxide Synthase Regulates Superoxide Generation from the Enzyme* , 2008, Journal of Biological Chemistry.
[75] D. Thedens,et al. Sarcolemma-localized nNOS is required to maintain activity after mild exercise , 2008, Nature.
[76] J. Stamler,et al. S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. , 2008, Molecular cell.
[77] M. Bonini,et al. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. , 2008, American journal of physiology. Endocrinology and metabolism.
[78] D. Tester,et al. Syntrophin mutation associated with long QT syndrome through activation of the nNOS–SCN5A macromolecular complex , 2008, Proceedings of the National Academy of Sciences.
[79] C. Klinge,et al. Resveratrol stimulates nitric oxide production by increasing estrogen receptor αa‐Src‐caveolin‐1 interaction and phosphorylation in human umbilical vein endothelial cells , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[80] Joanne Brown,et al. Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study. , 2008, Journal of the American College of Cardiology.
[81] L. Ignarro. Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol. , 2008, Cardiovascular therapeutics.
[82] P. Janssen,et al. Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban. , 2008, American journal of physiology. Cell physiology.
[83] James B. Mitchell,et al. Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin: Efficacy of Recoupling Nitric Oxide Synthase as a Therapeutic Strategy , 2008, Circulation.
[84] D. Kass,et al. Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease. , 2008, American journal of physiology. Heart and circulatory physiology.
[85] U. Förstermann,et al. Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling , 2008, Journal of Pharmacology and Experimental Therapeutics.
[86] Y. Sasaguri,et al. Spontaneous Myocardial Infarction in Mice Lacking All Nitric Oxide Synthase Isoforms , 2008, Circulation.
[87] A. Shah,et al. Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo , 2008, Circulation.
[88] E. Marbán,et al. CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart , 2008, Proceedings of the National Academy of Sciences.
[89] J. Zweier,et al. Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase. , 2008, Archives of biochemistry and biophysics.
[90] F. Gao,et al. IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.
[91] Mark J. Kohr,et al. Endothelial nitric oxide synthase decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+ current. , 2008, American journal of physiology. Heart and circulatory physiology.
[92] F. Zara,et al. Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro , 2008, Laboratory Investigation.
[93] M. Guazzi,et al. Endothelium‐mediated Modulation of Ergoreflex and Improvement in Exercise Ventilation by Acute Sildenafil in Heart Failure Patients , 2008, Clinical pharmacology and therapeutics.
[94] Z. Giricz,et al. Cardiac capsaicin‐sensitive sensory nerves regulate myocardial relaxation via S‐nitrosylation of SERCA: role of peroxynitrite , 2008, British journal of pharmacology.
[95] E. Kranias,et al. Reduced Phospholamban Phosphorylation Is Associated With Impaired Relaxation in Left Ventricular Myocytes From Neuronal NO Synthase–Deficient Mice , 2008, Circulation research.
[96] Anindita Das,et al. Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice. , 2007, American journal of physiology. Heart and circulatory physiology.
[97] J. Hare,et al. Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes , 2007, Proceedings of the National Academy of Sciences.
[98] D. Harrison,et al. Regulation of Tetrahydrobiopterin Biosynthesis by Shear Stress , 2007, Circulation research.
[99] G. Lembo,et al. Nebivolol Induces Nitric Oxide Release in the Heart Through Inducible Nitric Oxide Synthase Activation , 2007, Hypertension.
[100] J. Zweier,et al. Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4 , 2007, Proceedings of the National Academy of Sciences.
[101] J. P. Brennan,et al. Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation , 2007, Science.
[102] M. Mongillo,et al. Protein Kinase G Phosphorylates Cav1.2 α1c and β2 Subunits , 2007, Circulation research.
[103] U. Förstermann,et al. Reciprocal Regulation of Endothelial Nitric-Oxide Synthase and NADPH Oxidase by Betulinic Acid in Human Endothelial Cells , 2007, Journal of Pharmacology and Experimental Therapeutics.
[104] T. Meinertz,et al. Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation. , 2007, Journal of molecular and cellular cardiology.
[105] Matthew W. Foster,et al. Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2 , 2007, Cell.
[106] M. Picard,et al. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. , 2007, American journal of physiology. Heart and circulatory physiology.
[107] P. Vallance,et al. Disruption of methylarginine metabolism impairs vascular homeostasis , 2007, Nature Medicine.
[108] E. Cartwright,et al. Neuronal Nitric Oxide Synthase Signaling in the Heart Is Regulated by the Sarcolemmal Calcium Pump 4b , 2007, Circulation.
[109] G. Baumann,et al. Abstract 325: Alternative Splicing in Intron 13 of the Human eNOS Gene: A Potential Mechanism for Regulating eNOS Activity , 2006 .
[110] J. Tamargo,et al. Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism. , 2006, Cardiovascular research.
[111] R. Brandes,et al. Nebivolol Inhibits Superoxide Formation by NADPH Oxidase and Endothelial Dysfunction in Angiotensin II–Treated Rats , 2006, Hypertension.
[112] B. Rozec,et al. beta3-adrenoceptors in the cardiovascular system: putative roles in human pathologies. , 2006, Pharmacology & therapeutics.
[113] R. Schwinger,et al. ENOS is not activated by nebivolol in human failing myocardium. , 2006, Life sciences.
[114] Mark A Sussman,et al. Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy , 2006, Proceedings of the National Academy of Sciences.
[115] A. Marx,et al. Atheroprotective Effects of Neuronal Nitric Oxide Synthase in Apolipoprotein E Knockout Mice , 2006, Arteriosclerosis, thrombosis, and vascular biology.
[116] Christian Gieger,et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization , 2006, Nature Genetics.
[117] B. Casadei,et al. Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation. , 2006, Cardiovascular Research.
[118] H. Masuda,et al. Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of Bone Marrow–Derived Endothelial Progenitor Cells Into Sites of Ischemia-Induced Neovascularization via Endothelial Nitric Oxide Synthase–Mediated Activation of Matrix Metalloproteinase-9 , 2006, Circulation.
[119] A. Shoukas,et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[120] Irfan Rahman,et al. Redox modifications of protein-thiols: emerging roles in cell signaling. , 2006, Biochemical pharmacology.
[121] D. Bers,et al. Hypercontractile Female Hearts Exhibit Increased S-Nitrosylation of the L-Type Ca2+ Channel &agr;1 Subunit and Reduced Ischemia/Reperfusion Injury , 2006, Circulation research.
[122] R. Saraiva,et al. Xanthine Oxidoreductase Inhibition Causes Reverse Remodeling in Rats With Dilated Cardiomyopathy , 2006, Circulation research.
[123] T. Münzel,et al. Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure. , 2005, Biochemical and biophysical research communications.
[124] S. Neubauer,et al. nNOS Gene Deletion Exacerbates Pathological Left Ventricular Remodeling and Functional Deterioration After Myocardial Infarction , 2005, Circulation.
[125] R. Saraiva,et al. Deficiency of Neuronal Nitric Oxide Synthase Increases Mortality and Cardiac Remodeling After Myocardial Infarction: Role of Nitroso-Redox Equilibrium , 2005, Circulation.
[126] H. Shimokawa,et al. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans. , 2005, Journal of pharmacological sciences.
[127] D. Kass,et al. Reduced Wall Compliance Suppresses Akt-Dependent Apoptosis Protection Stimulated by Pulse Perfusion , 2005, Circulation research.
[128] C. Schöneich,et al. 3-Nitrotyrosine modification of SERCA2a in the aging heart: a distinct signature of the cellular redox environment. , 2005, Biochemistry.
[129] H. Cai,et al. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[130] A. Zeiher,et al. Concentric left ventricular remodeling in endothelial nitric oxide synthase knockout mice by chronic pressure overload. , 2005, Cardiovascular research.
[131] Z. Gąsior,et al. Effects of nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study , 2005, European journal of heart failure.
[132] D. Kass,et al. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. , 2005, The Journal of clinical investigation.
[133] S. Yusuf,et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. , 2005, JAMA.
[134] T. Asahara,et al. Endothelial Progenitor Cells Are Rapidly Recruited to Myocardium and Mediate Protective Effect of Ischemic Preconditioning via “Imported” Nitric Oxide Synthase Activity , 2005, Circulation.
[135] K. Channon,et al. Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. , 2005, Cardiovascular research.
[136] A. Ahluwalia,et al. Autoregulatory Role of Endothelium-derived Nitric Oxide (NO) on Lipopolysaccharide-induced Vascular Inducible NO Synthase Expression and Function* , 2005, Journal of Biological Chemistry.
[137] A. Cohen-Solal,et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). , 2005, European heart journal.
[138] B. Mayer,et al. Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide. , 2005, The Biochemical journal.
[139] D. Kass,et al. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy , 2005, Nature Medicine.
[140] J. Hare. Nitroso-redox balance in the cardiovascular system. , 2004, The New England journal of medicine.
[141] Ralph D'Agostino,et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. , 2004, The New England journal of medicine.
[142] J. Hare,et al. Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[143] X. Loyer,et al. Role of Myocardial Neuronal Nitric Oxide Synthase–Derived Nitric Oxide in &bgr;-Adrenergic Hyporesponsiveness After Myocardial Infarction–Induced Heart Failure in Rat , 2004, Circulation.
[144] H. Drexler,et al. Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase , 2004, Circulation.
[145] D. Webb,et al. Nebivolol Increases Arterial Distensibility In Vivo , 2004, Hypertension.
[146] L. Nelin,et al. Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells. , 2004, American journal of physiology. Lung cellular and molecular physiology.
[147] F. Van de Werf,et al. Cardiomyocyte-Specific Overexpression of Nitric Oxide Synthase 3 Improves Left Ventricular Performance and Reduces Compensatory Hypertrophy After Myocardial Infarction , 2004, Circulation research.
[148] A. Shah,et al. Increased neuronal nitric oxide synthase-derived NO production in the failing human heart , 2004, The Lancet.
[149] E. Ziff,et al. Bidirectional Regulation of Neuronal Nitric-oxide Synthase Phosphorylation at Serine 847 by the N-Methyl-d-aspartate Receptor* , 2004, Journal of Biological Chemistry.
[150] P. Boysen,et al. Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK. , 2004, American journal of physiology. Heart and circulatory physiology.
[151] H. Maeda,et al. Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. , 2003, The Journal of clinical investigation.
[152] T. Sawamura,et al. Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. , 2003, Journal of the American College of Cardiology.
[153] K. Pritchard,et al. Phosphorylation of Threonine 497 in Endothelial Nitric-oxide Synthase Coordinates the Coupling of l-Arginine Metabolism to Efficient Nitric Oxide Production* , 2003, Journal of Biological Chemistry.
[154] K. Channon,et al. A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation , 2003, Circulation research.
[155] A. Shoukas,et al. Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels , 2003, Circulation.
[156] C. Heeschen,et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells , 2003, Nature Medicine.
[157] T. Damy,et al. Up‐regulation of cardiac nitric oxide synthase 1‐derived nitric oxide after myocardial infarction in senescent rats , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[158] K. Rockett,et al. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. , 2003, The Journal of clinical investigation.
[159] Shinichiro Yamamoto,et al. Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. , 2003, Free Radical Biology & Medicine.
[160] F. Salloum,et al. Sildenafil Induces Delayed Preconditioning Through Inducible Nitric Oxide Synthase–Dependent Pathway in Mouse Heart , 2003, Circulation research.
[161] Steven P Jones,et al. Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[162] E. Ashley,et al. Cardiac Neuronal Nitric Oxide Synthase Isoform Regulates Myocardial Contraction and Calcium Handling , 2003, Circulation research.
[163] Y. Hattori,et al. HMG-CoA Reductase Inhibitor Increases GTP Cyclohydrolase I mRNA and Tetrahydrobiopterin in Vascular Endothelial Cells , 2003, Arteriosclerosis, thrombosis, and vascular biology.
[164] D. Paterson,et al. Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise‐trained mice , 2003, The Journal of physiology.
[165] B. Kalyanaraman,et al. The Role of Tetrahydrobiopterin in Superoxide Generation from eNOS: Enzymology and Physiological Implications , 2003, Free radical research.
[166] F. Grosveld,et al. Reduction of Blood Pressure, Plasma Cholesterol, and Atherosclerosis by Elevated Endothelial Nitric Oxide* , 2002, The Journal of Biological Chemistry.
[167] D. Harrison,et al. Vascular Oxidative Stress and Endothelial Dysfunction in Patients With Chronic Heart Failure: Role of Xanthine-Oxidase and Extracellular Superoxide Dismutase , 2002, Circulation.
[168] Xiangru Lu,et al. Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis. , 2002, American journal of physiology. Heart and circulatory physiology.
[169] A. Goette,et al. Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation: Potential Mechanisms for Atrial Thrombosis and Stroke , 2002, Circulation.
[170] David S. Park,et al. Caveolin-3 Knock-out Mice Develop a Progressive Cardiomyopathy and Show Hyperactivation of the p42/44 MAPK Cascade* , 2002, The Journal of Biological Chemistry.
[171] S. Rajagopalan,et al. Altered Tetrahydrobiopterin Metabolism in Atherosclerosis: Implications for Use of Oxidized Tetrahydrobiopterin Analogues and Thiol Antioxidants , 2002, Arteriosclerosis, thrombosis, and vascular biology.
[172] U. Förstermann,et al. Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase , 2002, Circulation.
[173] S. Daff,et al. Calmodulin Activates Electron Transfer through Neuronal Nitric-oxide Synthase Reductase Domain by Releasing an NADPH-dependent Conformational Lock* , 2002, The Journal of Biological Chemistry.
[174] E. Ashley,et al. Cardiac Nitric Oxide Synthase 1 Regulates Basal and &bgr;-Adrenergic Contractility in Murine Ventricular Myocytes , 2002, Circulation.
[175] J. Stamler,et al. Identification of the enzymatic mechanism of nitroglycerin bioactivation , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[176] P. Ping,et al. Nitric Oxide (NO) Induces Nitration of Protein Kinase Cε (PKCε), Facilitating PKCε Translocation via Enhanced PKCε-RACK2 Interactions , 2002, The Journal of Biological Chemistry.
[177] A. Shah,et al. Role of cyclic GMP‐dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes , 2002, The Journal of physiology.
[178] Joao A. C. Lima,et al. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. , 2002 .
[179] J. Joseph,et al. The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. , 2002, The Biochemical journal.
[180] R. Cohen,et al. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. , 2002, The Journal of clinical investigation.
[181] D. Kass,et al. Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart , 2002, Circulation research.
[182] S. Sasayama,et al. Augmented Expression of Neuronal Nitric Oxide Synthase in the Atria Parasympathetically Decreases Heart Rate During Acute Myocardial Infarction in Rats , 2002, Circulation.
[183] C. Jones,et al. Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. , 2001, Clinical science.
[184] T. Meinertz,et al. Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease , 2001, Circulation.
[185] J. Beavo,et al. Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate Tolerance , 2001, Circulation.
[186] C. Berul,et al. In Vivo Electrophysiologic Studies in Endothelial Nitric Oxide Synthase (eNOS)‐Deficient Mice , 2001, Journal of cardiovascular electrophysiology.
[187] J. Balligand,et al. Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes , 2001, Nature Cell Biology.
[188] Richard T. Lee,et al. Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice , 2001, Circulation.
[189] Maryl R. Johnson,et al. The Challenge of Rejection and Cardiac Allograft Vasculopathy , 2001, Heart Failure Reviews.
[190] C. Cooper,et al. Nitric oxide synthases: structure, function and inhibition , 2001 .
[191] J. Dalesandro,et al. Liposome-Mediated Gene Transfection of Endothelial Nitric Oxide Synthase Reduces Endothelial Activation and Leukocyte Infiltration in Transplanted Hearts , 2001, Circulation.
[192] D. Power,et al. Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase* , 2001, The Journal of Biological Chemistry.
[193] P. Cannon,et al. Acute Cardiac Allograft Rejection in Nitric OxideSynthase-2−/− and Nitric Oxide Synthase-2+/+ Mice: Effects of Cellular Chimeras on Myocardial Inflammation and Cardiomyocyte Damage and Apoptosis , 2001, Circulation.
[194] A. Kamkin,et al. Inotropic response to β‐adrenergic receptor stimulation and anti‐adrenergic effect of ACh in endothelial NO synthase‐deficient mouse hearts , 2001, The Journal of physiology.
[195] E. Werner,et al. Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy , 2001, JBIC Journal of Biological Inorganic Chemistry.
[196] T. Yamashita,et al. Endothelial NO Synthase Overexpression Inhibits Lesion Formation in Mouse Model of Vascular Remodeling , 2001, Arteriosclerosis, thrombosis, and vascular biology.
[197] R. Cartier,et al. CORONARY ARTERY ENDOTHELIAL DYSFUNCTION AFTER ISCHEMIA-REPERFUSION AND ACUTE UNTREATED REJECTION IN A CANINE HETEROTOPIC HEART TRANSPLANTATION MODEL , 2001, Transplantation.
[198] H Shimokawa,et al. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. , 2000, The Journal of clinical investigation.
[199] A. Takeshita,et al. Different Vasculoprotective Roles of NO Synthase Isoforms in Vascular Lesion Formation in Mice , 2000, Arteriosclerosis, thrombosis, and vascular biology.
[200] Y. Watanabe,et al. Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. , 2000, The Journal of biological chemistry.
[201] R. D. Rudic,et al. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. , 2000, The Journal of clinical investigation.
[202] V. Miller,et al. Gene transfer of endothelial nitric oxide synthase to pulmonary allografts: impact on acute rejection , 2000, Transplant international : official journal of the European Society for Organ Transplantation.
[203] N. Blau,et al. Tetrahydrobiopterin biosynthesis, regeneration and functions. , 2000, The Biochemical journal.
[204] K. Takeda,et al. Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes. , 2000, Journal of the American College of Cardiology.
[205] P. Huang,et al. Modulation of mouse cardiac function in vivo by eNOS and ANP. , 2000, American journal of physiology. Heart and circulatory physiology.
[206] H. Granger,et al. Inositol phosphate metabolism and nitric-oxide synthase activity in endothelial cells are involved in the vasorelaxant activity of nebivolol. , 2000, The Journal of pharmacology and experimental therapeutics.
[207] C. Krebs,et al. Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. , 1999, Biochemistry.
[208] R. Aebersold,et al. Identification of Flow-dependent Endothelial Nitric-oxide Synthase Phosphorylation Sites by Mass Spectrometry and Regulation of Phosphorylation and Nitric Oxide Production by the Phosphatidylinositol 3-Kinase Inhibitor LY294002* , 1999, The Journal of Biological Chemistry.
[209] K. Pritchard,et al. Tetrahydrobiopterin-dependent Inhibition of Superoxide Generation from Neuronal Nitric Oxide Synthase* , 1999, The Journal of Biological Chemistry.
[210] R. Busse,et al. Signal transduction of eNOS activation. , 1999, Cardiovascular research.
[211] H. Yokokura,et al. Regulation of Neuronal Nitric-oxide Synthase by Calmodulin Kinases* , 1999, The Journal of Biological Chemistry.
[212] R. Busse,et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation , 1999, Nature.
[213] W. Sessa,et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt , 1999, Nature.
[214] P. Huang,et al. Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. , 1999, American journal of physiology. Heart and circulatory physiology.
[215] V. Miller,et al. Distribution and function of recombinant endothelial nitric oxide synthase in transplanted hearts. , 1999, Cardiovascular research.
[216] J. Stamler,et al. Regulation of ryanodine receptors by reactive nitrogen species. , 1999, Biochemical pharmacology.
[217] O. Griffith,et al. Mammalian nitric oxide synthases. , 1999, Advances in enzymology and related areas of molecular biology.
[218] P. Mcconnell,et al. Endogenous endothelial nitric oxide synthase-derived nitric oxide is a physiological regulator of myocardial oxygen consumption. , 1999, Circulation research.
[219] V. J. Venema,et al. VEGF induces nuclear translocation of Flk-1/KDR, endothelial nitric oxide synthase, and caveolin-1 in vascular endothelial cells. , 1999, Biochemical and biophysical research communications.
[220] R. Fischmeister,et al. Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase , 1999, Nature Medicine.
[221] D. Bredt,et al. Nitric oxide synthase in cardiac sarcoplasmic reticulum. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[222] T. Poulos,et al. Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase A Paradigm for Pterin Function Involving a Novel Metal Center , 1998, Cell.
[223] J. Balligand,et al. The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. , 1998, The Journal of clinical investigation.
[224] H. Drexler,et al. Expression, activity and functional significance of inducible nitric oxide synthase in the failing human heart. , 1998, Journal of the American College of Cardiology.
[225] R. Virmani,et al. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. , 1998, The Journal of clinical investigation.
[226] D. Harrison,et al. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. , 1997, Arteriosclerosis, thrombosis, and vascular biology.
[227] W. Mayhan,et al. Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity. , 1997, The American journal of physiology.
[228] D. Pinsky,et al. Mechanical transduction of nitric oxide synthesis in the beating heart. , 1997, Circulation research.
[229] B. Prendergast,et al. Basal release of nitric oxide augments the Frank-Starling response in the isolated heart. , 1997, Circulation.
[230] J. Vilaine,et al. Time course of coronary endothelial dysfunction in acute untreated rejection after heterotopic heart transplantation. , 1997, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
[231] J. Brewer,et al. GTP Cyclohydrolase I Feedback Regulatory Protein Is a Pentamer of Identical Subunits , 1997, The Journal of Biological Chemistry.
[232] D. Wink,et al. The Nitric Oxide/Superoxide Assay , 1997, The Journal of Biological Chemistry.
[233] S. Snyder,et al. Neuronal nitric oxide synthase alternatively spliced forms: prominent functional localizations in the brain. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[234] E. Werner,et al. Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. , 1996, Biochemistry.
[235] M. Wolin,et al. Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration. Involvement in response to hypoxia/reoxygenation. , 1996, Circulation.
[236] J S Beckman,et al. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. , 1996, The American journal of physiology.
[237] J. Stamler,et al. Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols , 1996, The Journal of general physiology.
[238] S. Rajagopalan,et al. Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug. , 1996, The Journal of clinical investigation.
[239] L. Kobzik,et al. Endothelial Nitric Oxide Synthase Targeting to Caveolae , 1996, The Journal of Biological Chemistry.
[240] T. Bonner,et al. Purification and Cloning of the GTP Cyclohydrolase I Feedback Regulatory Protein, GFRP* , 1996, The Journal of Biological Chemistry.
[241] I. Rodrı́guez-Crespo,et al. Endothelial Nitric-oxide Synthase , 1996, The Journal of Biological Chemistry.
[242] E. Sheta,et al. Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate‐liganded heme protein that hydroxylates L‐arginine to produce NO as a cellular signal , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[243] D. Bredt,et al. Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains , 1996, Cell.
[244] D. Kass,et al. Minimal role of nitric oxide in basal coronary flow regulation and cardiac energetics of blood‐perfused isolated canine heart. , 1996, The Journal of physiology.
[245] P. Tsao,et al. Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle. , 1996, Circulation.
[246] U. Förstermann,et al. Expression of inducible nitric oxide synthase in failing and non-failing human heart. , 1996, Journal of molecular and cellular cardiology.
[247] J. Balligand,et al. Glucocorticoids Increase Osteopontin Expression in Cardiac Myocytes and Microvascular Endothelial Cells , 1995, The Journal of Biological Chemistry.
[248] W. Paulus,et al. Paracrine coronary endothelial control of left ventricular function in humans. , 1995, Circulation.
[249] J. Balligand,et al. Nitric Oxide-dependent Parasympathetic Signaling Is Due to Activation of Constitutive Endothelial (Type III) Nitric Oxide Synthase in Cardiac Myocytes (*) , 1995, The Journal of Biological Chemistry.
[250] J. Ahlner,et al. Mechanisms of action of nitrates , 1994, Cardiovascular Drugs and Therapy.
[251] J. Bauer,et al. Mechanisms of nitrate tolerance , 1994, Cardiovascular Drugs and Therapy.
[252] S Moncada,et al. Nitric oxide synthases in mammals. , 1994, The Biochemical journal.
[253] Y. Hattori,et al. GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase. , 1993, Biochemical and biophysical research communications.
[254] M. Edelstein,et al. Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[255] A. Hale,et al. Cardiomyocyte-targeted overexpression of GTP cyclohydrolase-1 increases nNOS activity and hastens myocardial relaxation , 2011 .
[256] Christian Jung,et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. , 2010, Cardiovascular research.
[257] T. Adachi. Modulation of vascular sarco/endoplasmic reticulum calcium ATPase in cardiovascular pathophysiology. , 2010, Advances in pharmacology.
[258] J. Hare,et al. Role of xanthine oxidoreductase in cardiac nitroso-redox imbalance. , 2009, Frontiers in bioscience.
[259] P. Massart,et al. Decreased expression of myocardial eNOS and caveolin in dogs with hypertrophic cardiomyopathy. , 2002, American journal of physiology. Heart and circulatory physiology.
[260] S. Kawachi,et al. Role of nitric oxide in the regulation of acute and chronic inflammation. , 2000, Antioxidants & redox signaling.
[261] D. Bredt,et al. Regulation of neuronal nitric oxide synthase through alternative transcripts. , 1997, Developmental neuroscience.
[262] B. Masters,et al. Erratum: Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: Structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO· as a cellular signal (The FASEB Journal (1996) 10 (552-558)) , 1996 .
[263] J. Vane,et al. Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production. , 1993, Advances in experimental medicine and biology.