Surgical site infection after pelvic bone and soft tissue sarcoma resection: Risk factors, microbiology, and impact of extended postoperative antibiotic prophylaxis

Pelvic bone and/or soft tissue sarcoma removal surgeries are associated with a high rate of surgical site infection (SSI). The recommended antibiotic prophylaxis (ABP) duration is 24−48 h. We aimed to assess the impact of extended ABP (5 days) on the SSI rate and describe the microbiology of SSI in bone and/or soft tissue pelvic sarcomas.

[1]  B. Brigman,et al.  Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration , 2022, Antimicrobial agents and chemotherapy.

[2]  Katsuhiro Hayashi,et al.  Surgical Site Infection after Bone Tumor Surgery: Risk Factors and New Preventive Techniques , 2022, Cancers.

[3]  Duncan C. Ramsey,et al.  Is the Addition of Anaerobic Coverage to Perioperative Antibiotic Prophylaxis During Soft Tissue Sarcoma Resection Associated With a Reduction in the Proportion of Wound Complications? , 2022, Clinical orthopaedics and related research.

[4]  G. Guyatt,et al.  Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors , 2022, JAMA oncology.

[5]  M. Lehnhardt,et al.  Antibiotic prophylaxis for prevention of wound infections after soft tissue sarcoma resection: A retrospective cohort study , 2020, Journal of surgical oncology.

[6]  E. P. Dellinger,et al.  Effect of postoperative continuation of antibiotic prophylaxis on the incidence of surgical site infection: a systematic review and meta-analysis. , 2020, The Lancet. Infectious diseases.

[7]  W. Tyler,et al.  Risk Factors for Surgical Site Infection in Orthopaedic Oncology. , 2020, The Journal of the American Academy of Orthopaedic Surgeons.

[8]  J. Wunder,et al.  Risk factors for postoperative wound complications after extremity soft tissue sarcoma resection: A systematic review and meta-analyses. , 2019, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[9]  R. Meneghini,et al.  Extended Oral Antibiotic Prophylaxis in High-Risk Patients Substantially Reduces Primary Total Hip and Knee Arthroplasty 90-Day Infection Rate , 2018, The Journal of bone and joint surgery. American volume.

[10]  D. Lebeaux,et al.  Successful 6-Week Antibiotic Treatment for Early Surgical-site Infections in Spinal Surgery. , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  A. Hamel,et al.  Postoperative infections after limb-sparing surgery for primary bone tumors of the pelvis: Incidence, characterization and functional impact. , 2017, Surgical oncology.

[12]  M. Boermeester,et al.  Global Guidelines for the Prevention of Surgical Site Infection , 2016 .

[13]  D. Biau,et al.  High Frequency of Polymicrobial Infections After Surgical Resection of Malignant Bone and Soft Tissue Tumors: A Retrospective Cohort Study , 2015, Infectious Diseases and Therapy.

[14]  S. Msika,et al.  Effect of postoperative antibiotic administration on postoperative infection following cholecystectomy for acute calculous cholecystitis: a randomized clinical trial. , 2014, JAMA.

[15]  A. Rebecca,et al.  Predictive Factors of Wound Complications After Sarcoma Resection Requiring Plastic Surgeon Involvement , 2013, Annals of plastic surgery.

[16]  A. Sauvanet,et al.  Five days of postoperative antimicrobial therapy decreases infectious complications following pancreaticoduodenectomy in patients at risk for bile contamination. , 2013, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[17]  F. Farrokhyar,et al.  High Infection Rate Outcomes in Long-bone Tumor Surgery with Endoprosthetic Reconstruction in Adults: A Systematic Review , 2013, Clinical orthopaedics and related research.

[18]  M. Bhandari,et al.  Prophylactic antibiotic regimens in tumor surgery (PARITY) survey , 2012, BMC Musculoskeletal Disorders.

[19]  H. Imamura,et al.  Intraoperative versus extended antimicrobial prophylaxis after gastric cancer surgery: a phase 3, open-label, randomised controlled, non-inferiority trial. , 2012, The Lancet. Infectious diseases.

[20]  Javad Parvizi,et al.  New definition for periprosthetic joint infection. , 2011, American journal of orthopedics.

[21]  Société Française d'Anesthésie et de Réanimation [Antibioprophylaxis in surgery and interventional medicine (adult patients). Actualization 2010]. , 2011, Annales francaises d'anesthesie et de reanimation.

[22]  A. Hidrón,et al.  Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007 , 2008, Infection Control & Hospital Epidemiology.

[23]  R. Grimer,et al.  Periprosthetic infection in patients treated for an orthopaedic oncological condition. , 2005, The Journal of bone and joint surgery. American volume.

[24]  Y. Carmeli,et al.  Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. , 2000, Circulation.

[25]  K. Dusenbery,et al.  Soft tissue sarcomas: Preoperative versus postoperative radiotherapy , 1996, Journal of surgical oncology.

[26]  C. Dolea,et al.  World Health Organization , 1949, International Organization.

[27]  New definition for periprosthetic joint infection. , 2011, The Journal of arthroplasty.

[28]  P. Maestracci Politique scientifique de la Société Française d'Anesthésie et de Réanimation , 1984 .