The NLRP3 inflammasome and gut dysbiosis as a putative link between HIV-1 infection and ischemic stroke

[1]  H. Vidal,et al.  Gut microbiota and stroke: New avenues to improve prevention and outcome , 2023, European journal of neurology.

[2]  Y. Hong,et al.  Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage. , 2023, European journal of pharmacology.

[3]  R. Burk,et al.  The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV , 2023, Current HIV/AIDS Reports.

[4]  M. Vijay-Kumar,et al.  Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy , 2023, Biomedicines.

[5]  N. Wu,et al.  Activation of NRF2 blocks HIV replication and apoptosis in macrophages , 2022, Heliyon.

[6]  R. Kashyap,et al.  The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke , 2022, Cells.

[7]  D. Chellappan,et al.  Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues. , 2022, CNS & neurological disorders drug targets.

[8]  Yingchao Li,et al.  Effect of intestinal microbiota transplantation on cerebral ischemia reperfusion injury in aged mice via inhibition of IL‐17 , 2022, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[9]  Shumei Wang,et al.  Integrated Analysis of the Cecal Microbiome and Plasma Metabolomics to Explore NaoMaiTong and Its Potential Role in Changing the Intestinal Flora and Their Metabolites in Ischemic Stroke , 2022, Frontiers in Pharmacology.

[10]  Lianyan Wei,et al.  Compositional and functional alterations of gut microbiota in patients with stroke. , 2021, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[11]  Bohyun Kim,et al.  TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer , 2021, Journal of Cancer.

[12]  Brittany D. Needham,et al.  Microbiota regulate social behaviour via stress response neurons in the brain , 2021, Nature.

[13]  Emma L. Koppe,et al.  Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages , 2021, PLoS pathogens.

[14]  Jiyuan Zhang,et al.  NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1-infected patients. , 2021, The Journal of clinical investigation.

[15]  M. Toborek,et al.  Expression of SARS-CoV-2-related Receptors in Cells of the Neurovascular Unit: Implications for HIV-1 Infection , 2021, Journal of Neuroinflammation.

[16]  M. Vlachou,et al.  Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review) , 2021, International journal of molecular medicine.

[17]  C. DeSelm,et al.  CARD8 is an inflammasome sensor for HIV-1 protease activity , 2021, Science.

[18]  Xiqun Zhu,et al.  The immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke , 2021, Journal of Neuroinflammation.

[19]  M. Toborek,et al.  Occludin, caveolin‐1, and Alix form a multi‐protein complex and regulate HIV‐1 infection of brain pericytes , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  T. Ishrat,et al.  HIV Associated Risk Factors for Ischemic Stroke and Future Perspectives , 2020, International journal of molecular sciences.

[21]  S. Daunert,et al.  The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies , 2020, Trends in Neurosciences.

[22]  P. Pelosi,et al.  Gut Microbiota in Acute Ischemic Stroke: From Pathophysiology to Therapeutic Implications , 2020, Frontiers in Neurology.

[23]  C. Pellegrini,et al.  Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications? , 2020, Progress in Neurobiology.

[24]  I. Vujkovic-Cvijin,et al.  HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases , 2020, Nature Communications.

[25]  Kevin S. Smith,et al.  C9orf72 suppresses systemic and neural inflammation induced by gut bacteria , 2020, Nature.

[26]  M. Suárez-Robles,et al.  HIV screening and its possible involvement in patients with stroke. , 2020, Enfermedades infecciosas y microbiologia clinica.

[27]  J. Simard,et al.  HIV-1 Vpr-Induced Proinflammatory Response and Apoptosis Are Mediated through the Sur1-Trpm4 Channel in Astrocytes , 2020, bioRxiv.

[28]  H. Shin,et al.  AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice , 2020, Brain, Behavior, and Immunity.

[29]  Zhenlian Wang,et al.  NLRP3 Inflammasome and Inflammatory Diseases , 2020, Oxidative medicine and cellular longevity.

[30]  A. Kim,et al.  Prevention of stroke in people living with HIV. , 2020, Progress in cardiovascular diseases.

[31]  G. Kroemer,et al.  HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry. , 2019, Cell reports.

[32]  E. Masliah,et al.  NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology , 2019, Cellular & Molecular Immunology.

[33]  A. Pontillo,et al.  Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals , 2019, Front. Immunol..

[34]  Zhi-Jian You,et al.  NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes , 2019, Journal of Neuroinflammation.

[35]  M. Toborek,et al.  Targeting the HIV-infected brain to improve ischemic stroke outcome , 2019, Nature Communications.

[36]  J. Filosa,et al.  NLRP3 inflammasome inhibition with MCC950 improves diabetes‐mediated cognitive impairment and vasoneuronal remodeling after ischemia , 2019, Pharmacological research.

[37]  K. Djafarian,et al.  Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. , 2019, Clinical nutrition.

[38]  M. Bogorodskaya,et al.  Stroke in HIV. , 2019, The Canadian journal of cardiology.

[39]  Amit J. Shah,et al.  HIV Infection and Incidence of Cardiovascular Diseases: An Analysis of a Large Healthcare Database , 2019, bioRxiv.

[40]  S. Carmichael,et al.  CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury , 2019, Cell.

[41]  M. Toborek,et al.  Blood–brain barrier pericytes as a target for HIV-1 infection , 2019, Brain : a journal of neurology.

[42]  A. Till,et al.  Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells , 2018, Front. Immunol..

[43]  G. Szabo,et al.  Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression , 2018, Journal of Neuroinflammation.

[44]  T. Tomita,et al.  Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats , 2018, Scientific Reports.

[45]  L. Pei,et al.  The role of NLRP3 inflammasome in stroke and central poststroke pain , 2018, Medicine.

[46]  J. Xie,et al.  Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients , 2018, Front. Microbiol..

[47]  O. Koren,et al.  Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders , 2018, Brain, Behavior, and Immunity.

[48]  Vikramjeet Singh,et al.  The gut microbiome primes a cerebroprotective immune response after stroke , 2018, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[49]  D. Montefiori,et al.  HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition , 2018, Nature Medicine.

[50]  J. Versalovic,et al.  Postnatal colonization with human "infant-type" Bifidobacterium species alters behavior of adult gnotobiotic mice , 2018, PloS one.

[51]  M. Rugeles,et al.  HIV replication is associated to inflammasomes activation, IL-1β, IL-18 and caspase-1 expression in GALT and peripheral blood , 2018, PloS one.

[52]  W. D. de Vos,et al.  Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study , 2018, BMC Research Notes.

[53]  M. Clerici,et al.  The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery , 2018, Front. Immunol..

[54]  D. Ercolini,et al.  Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice , 2018, Brain, Behavior, and Immunity.

[55]  J. Zhao,et al.  Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury , 2018, Behavioural Brain Research.

[56]  Rafael A. Irizarry,et al.  Meta-analysis of gut microbiome studies identifies disease-specific and shared responses , 2017, Nature Communications.

[57]  Qingsong Liu,et al.  Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders , 2017, The Journal of experimental medicine.

[58]  C. Power,et al.  HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation , 2016, Journal of Neuroimmune Pharmacology.

[59]  M. Teixeira,et al.  Knockdown of C-C Chemokine Receptor 5 (CCR5) is Protective Against Cerebral Ischemia and Reperfusion Injury. , 2017, Current neurovascular research.

[60]  S. Buch,et al.  HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation , 2017, The Journal of Neuroscience.

[61]  M. Toborek,et al.  Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity , 2016, Scientific Reports.

[62]  Jing Qiu,et al.  The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling. , 2016, International immunopharmacology.

[63]  B. Bartosch,et al.  Oxidative Stress during HIV Infection: Mechanisms and Consequences , 2016, Oxidative medicine and cellular longevity.

[64]  J. Kou,et al.  Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway , 2016, International journal of molecular sciences.

[65]  M. Dichgans,et al.  Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke , 2016, The Journal of Neuroscience.

[66]  V. Dixit,et al.  Inflammasomes: mechanism of assembly, regulation and signalling , 2016, Nature Reviews Immunology.

[67]  A. Bitto,et al.  ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury , 2016, Oxidative medicine and cellular longevity.

[68]  M. Katze,et al.  Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques , 2016, Journal of Virology.

[69]  T. Dinan,et al.  Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior , 2016, The international journal of neuropsychopharmacology.

[70]  M. Reale,et al.  Effect of Probiotic Supplement on Cytokine Levels in HIV-Infected Individuals: A Preliminary Study , 2015, Nutrients.

[71]  S. Johann,et al.  Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain , 2015, Neuroendocrinology.

[72]  C. Sanderson,et al.  Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways , 2015, Biochemical Society transactions.

[73]  Shiping Ma,et al.  Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome , 2015, Neuroscience Letters.

[74]  Shiping Ma,et al.  Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. , 2015, Toxicology and applied pharmacology.

[75]  K. Hua,et al.  Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy , 2015, Journal of cellular physiology.

[76]  Y. Tong,et al.  The NLRP3 inflammasome and stroke. , 2015, International journal of clinical and experimental medicine.

[77]  K. Schroder,et al.  A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases , 2015, Nature Medicine.

[78]  B. Friguet,et al.  Anti-Inflammatory and Antiatherogenic Effects of the NLRP3 Inflammasome Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet , 2015, Circulation.

[79]  N. Kootstra,et al.  Polymorphism in IFI16 affects CD4+ T‐cell counts in HIV‐1 infection , 2014, International journal of immunogenetics.

[80]  Chong Liu,et al.  Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome , 2014, CNS neuroscience & therapeutics.

[81]  M. Mattson,et al.  Intermittent fasting attenuates inflammasome activity in ischemic stroke , 2014, Experimental Neurology.

[82]  S. Paludan,et al.  Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation , 2014, Clinical and experimental immunology.

[83]  N. Krogan,et al.  IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV , 2014, Science.

[84]  Ziying Wang,et al.  NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[85]  M. Mattson,et al.  Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke , 2013, Cell Death and Disease.

[86]  Jun Chen,et al.  Pro: Regulatory T cells are protective in ischemic stroke. , 2013, Stroke.

[87]  J. Greenberg,et al.  Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[88]  B. Ryffel,et al.  MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury. , 2013, The Journal of clinical investigation.

[89]  Bernadette A. Thomas,et al.  Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[90]  Anna K Rieger,et al.  NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223 , 2012, The Journal of Immunology.

[91]  S. Khoo,et al.  HIV infection and stroke: current perspectives and future directions , 2012, The Lancet Neurology.

[92]  G. Kroemer,et al.  Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection , 2011, The Journal of experimental medicine.

[93]  R. Kaul,et al.  Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy , 2011, AIDS.

[94]  Pedro Romero,et al.  Type I interferon inhibits interleukin-1 production and inflammasome activation. , 2011, Immunity.

[95]  Egil Lien,et al.  NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals , 2010, Nature.

[96]  N. Rothwell,et al.  Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[97]  P. Hawkins,et al.  Use of canakinumab in the cryopyrin-associated periodic syndrome. , 2009, The New England journal of medicine.

[98]  M. McDermott,et al.  Inflammation: Canakinumab for the cryopyrin-associated periodic syndromes , 2009, Nature Reviews Rheumatology.

[99]  E. Alnemri,et al.  Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1 , 2009, The Journal of Immunology.

[100]  H. Hoffman Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS) , 2009 .

[101]  J. P. de Rivero Vaccari,et al.  Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[102]  D. Kastner,et al.  A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome. , 2008, Arthritis and rheumatism.

[103]  B. Gazzard,et al.  The impact of HIV tropism on decreases in CD4 cell count, clinical progression, and subsequent response to a first antiretroviral therapy regimen. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[104]  P. Hawkins,et al.  Use of Anakinra (Kineret) in the Treatment of Familial Cold Autoinflammatory Syndrome with a 16-Month Follow-Up , 2008, Journal of cutaneous medicine and surgery.

[105]  A. A. Mongin Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm. , 2007, Pathophysiology : the official journal of the International Society for Pathophysiology.

[106]  J. Brenchley,et al.  Microbial translocation is a cause of systemic immune activation in chronic HIV infection , 2006, Retrovirology.

[107]  N. Rothwell,et al.  A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[108]  D. Hess,et al.  SDF‐1 (CXCL12) Is Upregulated in the Ischemic Penumbra Following Stroke: Association with Bone Marrow Cell Homing to Injury , 2004, Journal of neuropathology and experimental neurology.

[109]  R. Macko,et al.  Acquired Immunodeficiency Syndrome and the Risk of Stroke , 2003, Stroke.

[110]  P. Aukrust,et al.  Raised serum levels of interleukin‐18 is associated with disease progression and may contribute to virological treatment failure in HIV‐1‐infected patients , 2003, Clinical and experimental immunology.

[111]  P. Greenberg,et al.  HIV-infected macrophages as efficient stimulator cells for detection of cytotoxic T cell responses to HIV in seronegative and seropositive vaccine recipients. , 1994, AIDS research and human retroviruses.

[112]  A. Sahebkar,et al.  Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys. , 2019, Drug discovery today.

[113]  P. A. Crawford,et al.  The ketone metabolite β-hydroxybutyrate blocks NLRP 3 inflammasome – mediated inflammatory disease , 2015 .

[114]  Scott Carver,et al.  Cytokine traps: multi-component, high-affinity blockers of cytokine action , 2003, Nature Medicine.