Estrogen receptor: A prognostic factor in breast cancer

Two‐hundred‐seventeen women with primary breast carcinoma had an estrogen receptor determination tested by both the dextran‐coated charcoal assay and sucrose density gradient. The results were correlated with the disease‐free interval, survival, response to hormone therapy or chemotherapy, and site of recurrent disease. The disease‐free interval (DFI) was significantly longer in premenopausal patients with estrogen receptor positive (ER+) determination compared with premenopausal patients with estrogen receptor negative (ER‐) determinations, irrespective of nodal involvement (P < 0.05). There was no difference between the postmenopausal patients.

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