Left hemisphere intracerebral hemorrhages studied by (F‐18)‐fluorodeoxyglucose PET

We used PET to study patients with intracerebral hemorrhages in the left hemisphere. Three anatomic and physiologic patterns were observed. Patients 1 and 2 had midputamen hemorrhages with diffuse left < right hemispheric metabolic asymmetry most prominent in temporal and parietal regions. Patients 3 and 4 had posterior putamen-insula-temporal hemorrhages with left < right metabolic asymmetry in temporoparietal cortex and thalamus. Patients 5, 6, and 7 had smaller posterior hemorrhages. Left cortical metabolism was little affected in these three cases. Persistent aphasia was associated with severe metabolic left < right asymmetry in posterior middle temporal regions.

[1]  M E Phelps,et al.  EFFECTS OF STROKE ON LOCAL CEREBRAL METABOLISM AND PERFUSION: MAPPING BY EMISSION COMPUTED TOMOGRAPHY OF 18FDG AND 13NH3 , 1980, Annals of neurology.

[2]  Claus-W. Wallesch,et al.  Lesions of the basal ganglia, thalamus, and deep white matter: Differential effects on language functions , 1983, Brain and Language.

[3]  D. Knopman,et al.  Computed tomographic scan correlates of auditory comprehension deficits in aphasia: A prospective recovery study , 1983, Annals of neurology.

[4]  David E. Kuhl,et al.  Correlations of glucose metabolism and structural damage to language function in aphasia , 1984, Brain and Language.

[5]  E. Kaplan,et al.  The assessment of aphasia and related disorders , 1972 .

[6]  A. Kertesz The Western Aphasia Battery , 1982 .

[7]  M. Alexander,et al.  Aphasia after left hemispheric intracerebral hemorrhage , 1980, Neurology.

[8]  E. Hoffman,et al.  Noninvasive determination of local cerebral metabolic rate of glucose in man. , 1980, The American journal of physiology.

[9]  C. Galletti,et al.  Projections from the visual cortical region of the superior temporal sulcus to the striatum and claustrum in the macaque monkey. , 1983, Archives italiennes de biologie.

[10]  M E Phelps,et al.  18FDG positron emission computed tomography in a study of aphasia , 1981, Annals of neurology.

[11]  R. Reale,et al.  Auditory cortical field projections to the basal ganglia of the cat , 1983, Neuroscience.

[12]  E. Metter,et al.  Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. , 1986, The American journal of psychiatry.

[13]  I. T. Draper THE ASSESSMENT OF APHASIA AND RELATED DISORDERS , 1973 .

[14]  J C Mazziotta,et al.  Quantitation in Positron Emission Computed Tomography: 5. Physical–Anatomical Effects , 1981, Journal of computer assisted tomography.

[15]  Daniel B Hier,et al.  Hypertensive putaminal hemorrhage , 1977, Annals of neurology.

[16]  M E Phelps,et al.  ECAT: a new computerized tomographic imaging system for positron-emitting radiopharmaceuticals. , 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[17]  A R Damasio,et al.  The anatomical basis of conduction aphasia. , 1980, Brain : a journal of neurology.

[18]  K. Davis,et al.  Thalamic hemorrhage , 1977, Neurology.

[19]  M. Mizukami,et al.  Computed Tomographic Findings of Good Prognosis For Hemiplegia in Hypertensive Putaminal Hemorrhage , 1981, Stroke.

[20]  L. Squire,et al.  Comparison of metabolic rates, language, and memory in subcortical aphasias , 1983, Brain and Language.

[21]  A. Kertesz,et al.  Computer tomographic localization, lesion size, and prognosis in aphasia and nonverbal impairment , 1979, Brain and Language.

[22]  Michael E. Phelps,et al.  Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [18F] Fluorodeoxyglucose Method , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[23]  E. Metter,et al.  Age and alcoholism: independent memory decrements. , 1984, Alcoholism, clinical and experimental research.

[24]  Kenneth E. Newhouse,et al.  The Metabolism of the Human Brain Studied with Positron Emission Tomography , 1985, The Yale Journal of Biology and Medicine.

[25]  E. Renzi,et al.  The token test: A sensitive test to detect receptive disturbances in aphasics. , 1962, Brain : a journal of neurology.

[26]  M. Alexander,et al.  Aphasia with predominantly subcortical lesion sites: description of three capsular/putaminal aphasia syndromes. , 1982, Archives of neurology.

[27]  A. Haerer,et al.  Long‐term prognosis of hypertensive intracerebral hemorrhage. , 1982, Stroke.

[28]  I. Illa,et al.  Thalamic Hemorrhage. A Study of 23 Patients With Diagnosis by Computed Tomography , 1981, Stroke.

[29]  J. Mazziotta,et al.  Study of Cerebral Function with Positron Computed Tomography , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[30]  E. Metter,et al.  Brain glucose metabolism and memory functions: age decrease in factor scores. , 1985, Journal of gerontology.