TO ENVIRONMENTAL GENOTOXICANTS

In real life, human exposure patterns are thus enormously complicat­ ed, with respect to both the multitude of single agents and the complex mixtures involved. The picture is further complicated by agents and ex­ posures acting synergistically or with contradicting inhibitory effects, i. e., antigenotoxicity. In the evaluation of the biologically significant exposures, therefore, it may be more relevant to look for early effects directly in the exposed individuals or groups than to try to predict potential hazards of the complex exposure patterns from data with single compounds. Focusing on the applicable methodologies in human monitoring is getting increasing attention.