NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

[1]  J. Burman,et al.  The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy , 2015, Nature.

[2]  F. Sutterwala,et al.  Initiation and perpetuation of NLRP3 inflammasome activation and assembly , 2015, Immunological reviews.

[3]  Akinori Eiyama,et al.  PINK1/Parkin-mediated mitophagy in mammalian cells. , 2015, Current opinion in cell biology.

[4]  John T. Chang,et al.  A gp130–Src–YAP module links inflammation to epithelial regeneration , 2015, Nature.

[5]  R. Schwabe,et al.  Hepatic inflammation and fibrosis: Functional links and key pathways , 2015, Hepatology.

[6]  Ruslan Medzhitov,et al.  Homeostasis, Inflammation, and Disease Susceptibility , 2015, Cell.

[7]  R. Vance The NAIP/NLRC4 inflammasomes. , 2015, Current opinion in immunology.

[8]  R. Youle,et al.  The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease , 2015, Neuron.

[9]  Jiujiu Yu,et al.  Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy , 2014, Proceedings of the National Academy of Sciences.

[10]  O. Ohara,et al.  Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response. , 2014, Cell reports.

[11]  J. Yagüe,et al.  The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response , 2014, Nature Immunology.

[12]  S. Hornemann,et al.  ASC has extracellular and prionoid activities that propagate inflammation , 2014, Nature Immunology.

[13]  Vishva M. Dixit,et al.  Mechanisms and Functions of Inflammasomes , 2014, Cell.

[14]  Katherine A. Fitzgerald,et al.  Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes , 2014, Cell.

[15]  S. Kim,et al.  NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1. , 2013, Free radical biology & medicine.

[16]  James L. Mueller,et al.  Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. , 2013, The Journal of clinical investigation.

[17]  G. Yap,et al.  Faculty Opinions recommendation of The ubiquitin ligase parkin mediates resistance to intracellular pathogens. , 2013 .

[18]  L. Galluzzi,et al.  Decoding cell death signals in liver inflammation. , 2013, Journal of hepatology.

[19]  T. Deerinck,et al.  Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. , 2013, The Journal of clinical investigation.

[20]  R. Vance,et al.  Recognition of bacteria by inflammasomes. , 2013, Annual review of immunology.

[21]  F. Sutterwala,et al.  TRPM2 links oxidative stress to the NLRP3 inflammasome activation , 2013, Nature Communications.

[22]  A. Walch,et al.  p62 links β-adrenergic input to mitochondrial function and thermogenesis. , 2013, The Journal of clinical investigation.

[23]  S. Kageyama,et al.  p62/SQSTM1/A170: physiology and pathology. , 2012, Pharmacological research.

[24]  Vishva M Dixit,et al.  Inflammasomes and their roles in health and disease. , 2012, Annual review of cell and developmental biology.

[25]  W. Hauswirth,et al.  DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 , 2012, Cell.

[26]  Moshe Arditi,et al.  Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. , 2012, Immunity.

[27]  A. Sher,et al.  Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction , 2012, Nature Immunology.

[28]  Richard A. Flavell,et al.  Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity , 2012, Nature.

[29]  Xiangmei Zhou,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[30]  S. Ryter,et al.  Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. , 2011, Nature immunology.

[31]  I. Weissman,et al.  IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ , 2011, Nature Immunology.

[32]  R. Youle,et al.  p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both , 2010, Autophagy.

[33]  A. Aderem,et al.  Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria , 2010, Nature Immunology.

[34]  Nobutaka Hattori,et al.  p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria , 2010, Genes to cells : devoted to molecular & cellular mechanisms.

[35]  L. Zitvogel,et al.  The IKK complex contributes to the induction of autophagy , 2010, The EMBO journal.

[36]  Fabienne C. Fiesel,et al.  PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 , 2010, Nature Cell Biology.

[37]  J. Tschopp,et al.  The Inflammasomes , 2010, Cell.

[38]  M. Diaz-Meco,et al.  p62 at the Crossroads of Autophagy, Apoptosis, and Cancer , 2009, Cell.

[39]  M. Karin,et al.  Regulation and function of NF-kappaB transcription factors in the immune system. , 2009, Annual review of immunology.

[40]  K. Ozato,et al.  The Sequestosome 1/p62 Attenuates Cytokine Gene Expression in Activated Macrophages by Inhibiting IFN Regulatory Factor 8 and TNF Receptor-Associated Factor 6/NF-κB Activity1 , 2009, The Journal of Immunology.

[41]  S. Anton,et al.  Molecular inflammation: Underpinnings of aging and age-related diseases , 2009, Ageing Research Reviews.

[42]  J. Satsangi Faculty Opinions recommendation of Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. , 2008 .

[43]  K. Rock,et al.  Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization , 2008, Nature Immunology.

[44]  R. Medzhitov Origin and physiological roles of inflammation , 2008, Nature.

[45]  Richard A. Flavell,et al.  Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants , 2008, Nature.

[46]  Masaaki Komatsu,et al.  Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice , 2007, Cell.

[47]  Rakesh K. Kumar,et al.  Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model. , 2007, Gastroenterology.

[48]  K. Zatloukal,et al.  In vitro production of Mallory bodies and intracellular hyaline bodies: The central role of sequestosome 1 / p62 , 2007, Hepatology.

[49]  M. Neuenhahn,et al.  NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. , 2007, Cell.

[50]  Michael Karin,et al.  Intracellular pattern recognition receptors in the host response , 2006, Nature.

[51]  K. Wirtz,et al.  Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress. , 2006, Biochimica et biophysica acta.

[52]  J. Auwerx,et al.  Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. , 2006, Cell metabolism.

[53]  K. Wirtz,et al.  Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress. B.V.Chernyak, D.S.Izyumov, K.G.Lyamzaev, A.A.Pashkovskaya, O.Y.Pletjushkina, Y.N.Antonenko, D.V.Sakharov , 2006 .

[54]  D. Wallace A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine , 2005, Annual review of genetics.

[55]  Claudio Franceschi,et al.  Innate immunity and inflammation in ageing: a key for understanding age-related diseases , 2005, Immunity & Ageing.

[56]  Masaaki Komatsu,et al.  Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice , 2005, The Journal of cell biology.

[57]  M. Karin,et al.  Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. , 1997, The New England journal of medicine.