Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis

We have evaluated the role of eosinophil cationic protein (ECP) concentrations in serum in predicting wheezing after bronchiolitis, during infancy and early childhood. A prospective study at a university hospital serving all pediatric patients in a defined area was designed. Serum ECP concentrations were measured in 92 infants under the age of 2 years on admission for acute bronchiolitis, and 6 and 16 weeks after hospitalization. Nebulized anti‐inflammatory therapy was initiated during hospitalization: 32 patients received cromolyn sodium and 32 patients received budesonide for 16 weeks; 30 control patients received no maintenance therapy. The numbers of subsequent physician‐diagnosed wheezing episodes and hospital admissions for obstructive airway disease were recorded during 16 weeks of follow‐up.

[1]  P. Venge,et al.  Radioimmunoassay of human eosinophil cationic protein (ECP) by an improved method. Establishment of normal levels in serum and turnover in vivo , 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[2]  Y. Sakiyama,et al.  Eosinophil cationic protein in peripheral blood of pediatric patients with allergic diseases , 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[3]  D. Loegering,et al.  Eosinophil- and eosinophil granule-mediated pneumocyte injury. , 1985, The Journal of allergy and clinical immunology.

[4]  R. Garofalo,et al.  Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. , 1992, The Journal of pediatrics.

[5]  R. Vaughan,et al.  Evaluation of serum eosinophilic cationic protein as a marker of disease activity in chronic asthma. , 1995, The Journal of allergy and clinical immunology.

[6]  S. Ahlstedt,et al.  Asthma in children less than 5 years of age: eosinophils and serum levels of the eosinophil proteins ECP and EPX in relation to atopy and symptoms , 1994, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  K. Carlsen,et al.  Eosinophil cationic protein and tidal flow volume loops in children 0-2 years of age. , 1995, The European respiratory journal.

[8]  W. Morgan,et al.  Asthma and wheezing in the first six years of life. The Group Health Medical Associates. , 1995, The New England journal of medicine.

[9]  R. Sorva,et al.  Serum eosinophil cationic protein during treatment of asthma in children. , 1993, The Journal of allergy and clinical immunology.

[10]  M. Korppi,et al.  Anti-inflammatory therapy reduces wheezing after bronchiolitis. , 1996, Archives of pediatrics & adolescent medicine.

[11]  D. Koller,et al.  Clinical value of monitoring eosinophil activity in asthma. , 1995, Archives of disease in childhood.

[12]  H. Simpson,et al.  Symptoms, atopy, and bronchial reactivity after lower respiratory infection in infancy. , 1984, Archives of disease in childhood.

[13]  N. Sigurs,et al.  Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy , 1994, Acta paediatrica.

[14]  D. Wong,et al.  The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection. , 1981, The New England journal of medicine.

[15]  B. Volovitz,et al.  The Release of Leukotrienes in the Respiratory Tract during Infection with Respiratory Syncytial Virus: Role in Obstructive Airway Disease , 1988, Pediatric Research.

[16]  T. Lövgren,et al.  Detection of viral antigens by time-resolved fluoroimmunoassay. , 1983, Current topics in microbiology and immunology.

[17]  S. Holgate,et al.  The role of the eosinophil in asthma. , 1991, The American review of respiratory disease.

[18]  P. Venge,et al.  Secretion of granule proteins from eosinophils and neutrophils is increased in asthma. , 1991, The Journal of allergy and clinical immunology.

[19]  J. Webb,et al.  Study of 8-year-old children with a history of respiratory syncytial virus bronchiolitis in infancy. , 1978, British medical journal.

[20]  R. S. Zimmerman,et al.  Total blood eosinophils, serum eosinophil cationic protein and eosinophil protein X in childhood asthma: relation to disease status and therapy , 1993, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[21]  B. Björkstén,et al.  Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. , 1995, Pediatrics.

[22]  P. Heymann,et al.  Eosinophil cationic protein in serum and nasal washes from wheezing infants and children. , 1995, The Journal of pediatrics.

[23]  M. Korppi,et al.  Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia. An 8-year follow-up study. , 1994, Archives of pediatrics & adolescent medicine.

[24]  M. Korppi,et al.  A 2- to 3-year outcome after bronchiolitis. , 1993, American journal of diseases of children.

[25]  P. Venge,et al.  The differential release of eosinophil granule proteins. Studies on patients with acute bacterial and viral infections , 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[26]  G. Gleich.  The eosinophil and bronchial asthma: current understanding. , 1990, The Journal of allergy and clinical immunology.

[27]  C. O’Callaghan,et al.  Respiratory status and allergy after bronchiolitis. , 1992, Archives of disease in childhood.

[28]  E. Hey,et al.  Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. , 1982, British medical journal.

[29]  S. Durham,et al.  Blood eosinophils and eosinophil-derived proteins in allergic asthma. , 1989, The Journal of allergy and clinical immunology.

[30]  M. Kajosaari,et al.  SERUM IMMUNOGLOBULIN E IN ATOPIC AND NON‐ATOPIC CHILDREN AGED 6 MONTHS TO 5 YEARS , 1982, Acta paediatrica Scandinavica.

[31]  P. Sly,et al.  Childhood asthma following hospitalization with acute viral bronchiolitis in infancy , 1989, Pediatric pulmonology.

[32]  G. M. Stokes,et al.  Respiratory problems 2 years after acute bronchiolitis in infancy. , 1983, Archives of disease in childhood.

[33]  M. Korppi,et al.  The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis. , 1995, Archives of pediatrics & adolescent medicine.

[34]  J. Bousquet,et al.  Eosinophilic inflammation in asthma. , 1990, The New England journal of medicine.

[35]  Ö. Strannegård,et al.  Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus , 1994, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[36]  L I Landau,et al.  Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis. , 1995, Archives of disease in childhood.