HLA DQ-DR haplotype and susceptibility to cervical carcinoma: indications of increased risk for development of cervical carcinoma in individuals infected with HPV 18.

The association of HLA class II DQB1 and DRB1 alleles with the development of cervical carcinoma was studied in 150 Swedish patients using PCR-based HPV and HLA typing. The association of cervical carcinoma with alleles encoding the DQ3 antigen, previously found among German and Norwegian patients, was not observed in the Swedish patients. Five DQ-DR haplotypes were indicated to be positively associated with development of cervical carcinoma in the Swedish patients. Two of these HLA associations were specific for HPV 18 infected patients, suggesting that the ability of the oncogenic HPV 18 to cause more rapid-transit tumors than other high risk HPV types may be due to a deficiency in antigen presentation by the HLA molecules encoded by carried on these haplotypes.

[1]  T. Bergström,et al.  Detection of genital human papillomavirus by single-tube nested PCR and type-specific oligonucleotide hybridization , 1995, Journal of clinical microbiology.

[2]  A. Børresen,et al.  DQA1 and DQB1 genes in patients with squamous cell carcinoma of the cervix: relationship to human papillomavirus infection and prognosis. , 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[3]  Kenichi Tanaka,et al.  Biological‐clinical significance of selective loss of HLA‐class‐I allelic product expression in squamous‐cell carcinoma of the uterine cervix , 1994, International journal of cancer.

[4]  W. Lancaster,et al.  Association between HLA‐DQB1 alleles and risk for cervical cancer in African‐American women , 1994, International journal of cancer.

[5]  C. Wheeler,et al.  Cigarette smoking and other risk factors for cervical dysplasia in southwestern Hispanic and non-Hispanic white women. , 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[6]  W. Klitz,et al.  HLA DR–DQ associations with cervical carcinoma show papillomavirus–type specificity , 1994, Nature Genetics.

[7]  F. X. Bosch,et al.  Human papillomavirus and cervical intraepithelial neoplasia grade III/carcinoma in situ: a case-control study in Spain and Colombia. , 1993, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[8]  F. X. Bosch,et al.  Risk factors for cervical intraepithelial neoplasia grade III/carcinoma in situ in Spain and Colombia. , 1993, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[9]  P. Stern,et al.  Lack of association of HLA polymorphisms with human papillomavirus-related cervical cancer. , 1993, Human immunology.

[10]  S Wacholder,et al.  Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. , 1993, Journal of the National Cancer Institute.

[11]  U. Gyllensten,et al.  Genetic typing of HLA class II genes in Swedish populations: application to forensic analysis. , 1993, Journal of forensic sciences.

[12]  M. Evander,et al.  Comparison of a one-step and a two-step polymerase chain reaction with degenerate general primers in a population-based study of human papillomavirus infection in young Swedish women , 1992, Journal of clinical microbiology.

[13]  P. Stern,et al.  HLA antigens and cervical carcinoma , 1992, Nature.

[14]  R Reid,et al.  Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. , 1992, Obstetrics and gynecology.

[15]  C. Thomssen,et al.  High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3 , 1991, Nature.

[16]  S. Vermund,et al.  Human papillomavirus infection and other risk factors for cervical neoplasia: A case‐control study , 1991, International journal of cancer.

[17]  Arnold J. Levine,et al.  The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 , 1990, Cell.

[18]  A. Levine,et al.  Association of human papillomavirus types 16 and 18 E6 proteins with p53. , 1990, Science.

[19]  J. Rothbard,et al.  Human T cell responses to human papillomavirus type 16 L1 and E6 synthetic peptides: identification of T cell determinants, HLA-DR restriction and virus type specificity. , 1990, The Journal of general virology.

[20]  G. Temple,et al.  Analysis of individual cervical human papillomavirus types in neolasia: A possible role for type 18 in rapid progression , 1988 .

[21]  D M Parkin,et al.  Estimates of the worldwide frequency of sixteen major cancers in 1980 , 1988, International journal of cancer.

[22]  J. Fraumeni,et al.  Sexual and reproductive risk factors for invasive squamous cell cervical cancer. , 1987, Journal of the National Cancer Institute.

[23]  S. Franceschi,et al.  Characteristics of women under 20 with cervical intraepithelial neoplasia. , 1986, International journal of epidemiology.

[24]  W. Haenszel,et al.  Cigarette smoking and invasive cervical cancer. , 1986, JAMA.

[25]  C. Crum,et al.  In situ hybridization analysis of HPV 16 DNA sequences in early cervical neoplasia. , 1986, The American journal of pathology.

[26]  C. Crum,et al.  Human papillomavirus type 16 and early cervical neoplasia. , 1984, The New England journal of medicine.

[27]  L. Gissmann,et al.  A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[28]  W. Droegemueller,et al.  Gynecologic Malignancies in Immunosuppressed Organ Homograft Recipients , 1975, Obstetrics and gynecology.

[29]  B. Haldane.  THE ESTIMATION AND SIGNIFICANCE OF THE LOGARITHM OF A RATIO OF FREQUENCIES , 1956, Annals of human genetics.

[30]  B. Woolf.  ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASE , 1955, Annals of human genetics.

[31]  G. Fleuren,et al.  The expression of histocompatibility-related leukocyte antigens in the pathway to cervical carcinoma. , 1994, American journal of clinical pathology.

[32]  J. Bodmer,et al.  HLA Class II nucleotide sequences, 1992. , 1993, Immunobiology.

[33]  H. Erlich,et al.  Rapid typing of DNA sequence polymorphism at the HLA-DRB1 locus using the polymerase chain reaction and nonradioactive oligonucleotide probes. , 1991, Human immunology.

[34]  P. Layde,et al.  Carcinoma of the cervix and smoking. , 1989, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[35]  H. Kirchner.  Immunobiology of human papillomavirus infection. , 1986, Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progres en virologie medicale.