Common region on chromosome 14 in T-cell leukemia and lymphoma.

Chromosome 14 breakpoints in malignant human lymphocytes cluster on the long (q) arm near bands q11 and q32. An inversion of chromosome 14 due to breaks in q11.2 and q32.3 has now been found in a newly established childhood T-cell lymphoma cell line and confirmed in T-cell chronic lymphocytic leukemia. A translocation was also found between chromosomes 10 and 14 with a breakpoint at 14q11.2 in another T-cell lymphoma cell line. It is proposed that a proximal region on chromosome 14 in or near sub-band q11.2 is related to T-cell function. Rearrangements in this region may affect the growth of T lymphocytes and be involved in the development of T-cell malignancies.

[1]  J. Winter,et al.  Cytogenetic studies on patients with chronic T cell leukemia/lymphoma. , 1984, Blood.

[2]  A. Look,et al.  New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia , 1984, Cell.

[3]  L. Zech,et al.  Chromosomal aberrations in a case of T‐cell CLL with concomitant IgA myeloma , 1983, International journal of cancer.

[4]  D. Roos,et al.  Enzyme analysis of lymphoproliferative diseases: a useful addition to cell surface phenotyping. , 1983, Blood.

[5]  R. Chaganti.  Significance of chromosome change to hematopoietic neoplasms. , 1983, Blood.

[6]  J. Yunis.  The chromosomal basis of human neoplasia. , 1983, Science.

[7]  T. Waldmann,et al.  Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. , 1983, The Journal of clinical investigation.

[8]  J. Rowley.  Onco gen: Human oncogene locations and chromosome aberrations , 1983, Nature.

[9]  Y. Kaneko,et al.  Correlation of karyotype with clinical features in acute lymphoblastic leukemia. , 1982, Cancer research.

[10]  P. Leder,et al.  Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. , 1982, Science.

[11]  Stephen D. Smith,et al.  In vitro growth of lymphoma colonies from children with non‐hodgkin's lymphoma , 1981, Cancer.

[12]  S. Smith,et al.  Colony formation in vitro by leukemic cells in acute lymphoblastic leukemia (ALL). , 1978, Blood.

[13]  G. Klein,et al.  Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomas , 1976, International journal of cancer.

[14]  F. Hecht,et al.  Somatic rearrangement of chromosome 14 in human lymphocytes. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[15]  L. Zech,et al.  Inversion of chromosome 14 marks human T-cell chronic lymphocytic leukaemia , 1984, Nature.

[16]  M. Ferguson-Smith,et al.  Regional assignment of nucleoside phosphorylase by exclusion to 14q13. , 1978, Cytogenetics and cell genetics.