Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis
暂无分享,去创建一个
Anton J. Enright | Ian Dunham | Andrew G Fraser | Ian Sudbery | Anton J Enright | A. Fraser | A. Enright | I. Dunham | I. Sudbery
[1] K. Heidenreich,et al. Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein* , 2000, The Journal of Biological Chemistry.
[2] John G Doench,et al. Comparison of siRNA-induced off-target RNA and protein effects. , 2007, RNA.
[3] J. Pollack,et al. MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. , 2008, Blood.
[4] J. Partanen,et al. c-Myc Blazing a Trail of Death: Coupling of the Mitochondrial and Death Receptor Apoptosis Pathways by c-Myc , 2007, Cell cycle.
[5] Henning Walczak,et al. TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL , 1997, The EMBO journal.
[6] Arul M. Chinnaiyan,et al. The Receptor for the Cytotoxic Ligand TRAIL , 1997, Science.
[7] Nir Hacohen,et al. Minimizing the risk of reporting false positives in large-scale RNAi screens , 2006, Nature Methods.
[8] Anindya Dutta,et al. Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation , 2003, Journal of Biological Chemistry.
[9] P. Hersey,et al. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. , 1999, Cancer research.
[10] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[11] G. Cohen,et al. Protein Kinase C Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Targeting the Apical Events of Death Receptor Signaling* , 2003, Journal of Biological Chemistry.
[12] Serge Batalov,et al. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. , 2003, Molecular cell.
[13] Q. Deveraux,et al. A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[14] S. Marsters,et al. Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family* , 1996, The Journal of Biological Chemistry.
[15] R. K Srivastava,et al. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer , 2001, Oncogene.
[16] C. Rauch,et al. Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo , 1999, Nature Medicine.
[17] L. Lim,et al. Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. , 2006, RNA.
[18] R. K Srivastava,et al. Pro-survival Function of Akt/Protein Kinase B in Prostate Cancer Cells , 2001, The Journal of Biological Chemistry.
[19] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[20] W. El-Deiry,et al. Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity , 2004, Molecular and Cellular Biology.
[21] G. Cohen,et al. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia , 2002, Oncogene.
[22] Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[23] John Calvin Reed,et al. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. , 1998, Molecular cell.
[24] A. Kraft,et al. RAS, MYC, and sensitivity to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis. , 2005, Cancer research.
[25] C. Sander,et al. A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing , 2007, Cell.
[26] R. Bernards,et al. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. , 2005, Molecular cell.
[27] Michael T. Fisher,et al. Molecular determinants of response to TRAIL in killing of normal and cancer cells. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[28] G. Cavet,et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL , 2007, Nature Medicine.
[29] Anastasia Khvorova,et al. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets , 2006, Nature Methods.
[30] R. K Srivastava,et al. Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways , 2001, Oncogene.
[31] M. D'Andrea,et al. Expression of PDE11A in Normal and Malignant Human Tissues , 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[32] K. Flaherty,et al. Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. , 2007, Cancer cell.
[33] C. Creighton,et al. Widespread deregulation of microRNA expression in human prostate cancer , 2008, Oncogene.
[34] Wolfgang Huber,et al. Analysis of cell-based RNAi screens , 2006, Genome Biology.
[35] F. André,et al. Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. , 2005, The American journal of pathology.
[36] S. Fesik,et al. ‘Seed’ analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737 , 2007, Oncogene.
[37] Jeffrey P. MacKeigan,et al. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance , 2005, Nature Cell Biology.
[38] E. D. de Vries,et al. The clinical trail of TRAIL. , 2006, European journal of cancer.
[39] A. Winoto,et al. FADD Is Required for DR4- and DR5-mediated Apoptosis , 2000, The Journal of Biological Chemistry.
[40] R. Vyzula,et al. Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal Cancer , 2008, Oncology.
[41] B. Lüscher,et al. Function and regulation of the transcription factors of the Myc/Max/Mad network. , 2001, Gene.
[42] A. Kraft,et al. Oncogenic Ras Sensitizes Normal Human Cells to Tumor Necrosis Factor-α-Related Apoptosis-Inducing Ligand-Induced Apoptosis , 2004, Cancer Research.
[43] Yahong Lin,et al. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. , 2002, Genes & development.
[44] Marc Nasoff,et al. Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. , 2004, Cancer cell.
[45] Charles D. Johnson,et al. Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway. , 2007, Cancer research.
[46] G. Mortier,et al. qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data , 2007, Genome Biology.