Linking Frailty Instruments to the International Classification of Functioning, Disability, and Health: A Systematic Review.

To date, the major dilemma concerning frailty is the lack of a standardized language regarding its operationalization. Considering the demographic challenge that the world is facing, standardization of frailty identification is indeed the first step in tackling the burdensome consequences of frailty. To demonstrate this diversity in frailty assessment, the available frailty instruments have been linked to the International Classification of Functioning, Disability, and Health (ICF): a standardized and hierarchically coded language developed by World Health Organization regarding health conditions and their positive (functioning) and negative (disability) consequences. A systematic review on frailty instruments was carried out in PubMed, Web of Knowledge, and PsycINFO. The items of the identified frailty instruments were then linked to the ICF codes. 79 original or adapted frailty instruments were identified and categorized into single (n = 25) and multidomain (n = 54) groups. Only 5 frailty instruments (indexes) were linked to all 5 ICF components. Whereas the ICF components Body Functions and Activities and Participation were frequently linked to the frailty instruments, Body Structures, Environmental and Personal factors were sparingly represented mainly in the multidomain frailty instruments. This review highlights the heterogeneity in frailty operationalization. Environmental and personal factors should be given more thought in future frailty assessments. Being unambiguous, structured, and neutral, the ICF language allows comparing observations made with different frailty instruments. In conclusion, this systematic overview and ICF translation can be a cornerstone for future standardization of frailty assessment.

[1]  Marjan J Faber,et al.  Effects of exercise programs on falls and mobility in frail and pre-frail older adults: A multicenter randomized controlled trial. , 2006, Archives of physical medicine and rehabilitation.

[2]  R. Yu,et al.  Frailty Screening in the Community Using the FRAIL Scale. , 2015, Journal of the American Medical Directors Association.

[3]  L. Fried,et al.  Associations of subclinical cardiovascular disease with frailty. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[4]  Katrien G Luijkx,et al.  Toward a conceptual definition of frail community dwelling older people. , 2010, Nursing outlook.

[5]  H. Perry,et al.  Evaluation of assays available to measure free testosterone. , 2002, Metabolism: clinical and experimental.

[6]  Howard Bergman,et al.  Models, definitions, and criteria of frailty. , 2003, Aging clinical and experimental research.

[7]  Emma V. Ward,et al.  Psychometric properties of multicomponent tools designed to assess frailty in older adults: A systematic review , 2016, BMC Geriatrics.

[8]  A. Dobson,et al.  Validation of the FRAIL Scale in a Cohort of Older Australian Women , 2012, Journal of the American Geriatrics Society.

[9]  Rose Anne Kenny,et al.  A Frailty Instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE) , 2010, BMC geriatrics.

[10]  J. E. Morley,et al.  The I.A.N.A. task force on frailty assessment of older people in clinical practice , 2008, The journal of nutrition, health & aging.

[11]  H. Boter,et al.  Prevalence of Frailty in Community‐Dwelling Older Persons: A Systematic Review , 2012, Journal of the American Geriatrics Society.

[12]  Thomas M Gill,et al.  Transitions between frailty states among community-living older persons. , 2006, Archives of internal medicine.

[13]  A. P. Navarrete-Reyes,et al.  Social Determinants of Frailty in Elderly Mexican Community‐Dwelling Adults , 2012, Journal of the American Geriatrics Society.

[14]  Matthew T. Haren,et al.  Frailty and Hormones , 2005, Reviews in Endocrine and Metabolic Disorders.

[15]  G. Ravaglia,et al.  A comparison of frailty indexes for prediction of adverse health outcomes in an elderly cohort. , 2012, Archives of gerontology and geriatrics.

[16]  B. L. Beattie,et al.  Frailty in elderly people: an evolving concept. , 1994, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[17]  F. Buntinx,et al.  Identifying an accurate pre-screening tool in geriatric oncology. , 2010, Critical reviews in oncology/hematology.

[18]  R. Gobbens,et al.  In search of an integral conceptual definition of frailty: opinions of experts. , 2010, Journal of the American Medical Directors Association.

[19]  G David Batty,et al.  Measures of frailty in population-based studies: an overview , 2013, BMC Geriatrics.

[20]  R. Beiko,et al.  Frailty and the Microbiome. , 2015, Interdisciplinary topics in gerontology and geriatrics.

[21]  I. Drubbel,et al.  Screening for frailty in primary care: a systematic review of the psychometric properties of the frailty index in community-dwelling older people , 2014, BMC Geriatrics.

[22]  I. McDowell,et al.  A global clinical measure of fitness and frailty in elderly people , 2005, Canadian Medical Association Journal.

[23]  Stephanie Studenski,et al.  Geriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept , 2007, Journal of the American Geriatrics Society.

[24]  H. Allore,et al.  A program to prevent functional decline in physically frail, elderly persons who live at home. , 2002, The New England journal of medicine.

[25]  Fabio Tamburini,et al.  Should we screen for cognitive decline and dementia? , 2015, Maturitas.

[26]  Luigi Ferrucci,et al.  Frailty: an emerging research and clinical paradigm--issues and controversies. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[27]  A. Cieza,et al.  Content comparison of health-related quality of life instruments for COPD. , 2007, Respiratory medicine.

[28]  J. Woo,et al.  Social Determinants of Frailty , 2005, Gerontology.

[29]  Nenad Kostanjsek,et al.  ICF linking rules: an update based on lessons learned. , 2005, Journal of rehabilitation medicine.

[30]  G. Hankey,et al.  Low free testosterone predicts frailty in older men: the health in men study. , 2010, The Journal of clinical endocrinology and metabolism.

[31]  Matteo Cesari,et al.  Frailty consensus: a call to action. , 2013, Journal of the American Medical Directors Association.

[32]  T. Walsh,et al.  Testosterone and Sexual Function. , 2016, The Urologic clinics of North America.

[33]  C. Cooper,et al.  Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. , 2010, Age and ageing.

[34]  Robbert Gobbens,et al.  The comprehensive frailty assessment instrument: development, validity and reliability. , 2013, Geriatric nursing.

[35]  Kenneth Rockwood,et al.  Accumulation of Deficits as a Proxy Measure of Aging , 2001, TheScientificWorldJournal.

[36]  Tom Hickey,et al.  Health and aging , 1980 .

[37]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[38]  M. Loeb,et al.  Aging, frailty and age-related diseases , 2010, Biogerontology.

[39]  J. Woo,et al.  Public health significance of the frailty index , 2006, Disability and rehabilitation.

[40]  M. Andrew Frailty and Social Vulnerability. , 2015, Interdisciplinary topics in gerontology and geriatrics.

[41]  E. Gorus,et al.  Conversion of the Mini-Mental State Examination to the International Classification of Functioning, Disability and Health Terminology and Scoring System , 2011, Gerontology.

[42]  Catherine Sherrington,et al.  Effectiveness of a multifactorial intervention on preventing development of frailty in pre-frail older people: study protocol for a randomised controlled trial , 2015, BMJ Open.

[43]  T. Mets,et al.  Integrating the International Classification of Functioning, Disability and Health (ICF) in the geriatric minimum data SET-25 (GMDS-25) for intervention studies in older people , 2009, The journal of nutrition, health & aging.

[44]  Liz Gill,et al.  Treating frailty-a practical guide , 2011, BMC medicine.

[45]  C. Nash IDENTIFYING FRAILTY USING THE ICF: PROOF OF CONCEPT , 2008 .

[46]  John B. Young,et al.  Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review. , 2014, Age and ageing.

[47]  M. Petrovic,et al.  The advanced activities of daily living: A tool allowing the evaluation of subtle functional decline in mild cognitive impairment , 2012, The journal of nutrition, health & aging.

[48]  J. Morley,et al.  A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans , 2012, The journal of nutrition, health & aging.

[49]  Sathya Karunananthan,et al.  The Identification of Frailty: A Systematic Literature Review , 2011, Journal of the American Geriatrics Society.

[50]  T. Spector,et al.  Signatures of early frailty in the gut microbiota , 2016, Genome Medicine.

[51]  V. Quagliarello,et al.  The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases , 2015, Journal of the American Geriatrics Society.

[52]  Q. Xue The frailty syndrome: definition and natural history. , 2011, Clinics in geriatric medicine.

[53]  Bruno Vellas,et al.  The assessment of frailty in older adults. , 2010, Clinics in geriatric medicine.

[54]  Jean-Pierre Michel,et al.  Frailty Syndrome: A Transitional State in a Dynamic Process , 2009, Gerontology.

[55]  R. Gobbens,et al.  Determinants of frailty. , 2010, Journal of the American Medical Directors Association.

[56]  M.W.G. Nijhuis-van der Sanden,et al.  Outcome instruments to measure frailty: A systematic review , 2011, Ageing Research Reviews.

[57]  S. Iliffe,et al.  Frailty in elderly people , 2013, The Lancet.

[58]  L. Ferrucci,et al.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[59]  M. Cesari,et al.  Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group , 2013, The journal of nutrition, health & aging.

[60]  J. Jelsma Use of the International Classification of Functioning, Disability and Health: a literature survey. , 2009, Journal of rehabilitation medicine.

[61]  C. Stehouwer,et al.  The frailty dilemma. Review of the predictive accuracy of major frailty scores. , 2012, European journal of internal medicine.

[62]  R. Ravindrarajah,et al.  Frailty and sexual health in older European men. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[63]  P J Garry,et al.  Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. , 1997, Metabolism: clinical and experimental.

[64]  A. Sinclair,et al.  The geriatric minimum data set for clinical trials (GMDS) , 2008, The journal of nutrition, health & aging.

[65]  L. Ferrucci,et al.  Progressive versus catastrophic disability: a longitudinal view of the disablement process. , 1996, The journals of gerontology. Series A, Biological sciences and medical sciences.

[66]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.