iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy.
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Katherine B. LeClair | Alexander S. Banks | D. Drucker | L. Lynch | M. Brenner | E. Maratos-Flier | D. Cohen | D. O'Shea | M. Corrigan | A. Hogan | D. Duquette | Chantel Lester | B. Lu | D. Stevanovic | Abhisek Ghosh | D. Cohen
[1] R. Gimeno,et al. Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1. , 2015, Cell reports.
[2] W. D. van Marken Lichtenbelt,et al. Serum FGF21 levels are associated with brown adipose tissue activity in humans , 2015, Scientific Reports.
[3] R. Locksley,et al. Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis , 2015, Cell.
[4] Jonathan R. Brestoff,et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity , 2014, Nature.
[5] G. Besra,et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue , 2014, Nature Immunology.
[6] R. Palmiter,et al. Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat , 2014, Cell.
[7] N. Satoh,et al. Liraglutide Suppresses Obesity and Hyperglycemia Associated with Increases in Hepatic Fibroblast Growth Factor 21 Production in KKAy Mice , 2014, BioMed research international.
[8] L. Lynch,et al. Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus , 2014, Diabetologia.
[9] A. Adams,et al. Inventing new medicines: The FGF21 story☆ , 2013, Molecular metabolism.
[10] R. Locksley,et al. Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice , 2013, The Journal of Immunology.
[11] B. Sloth,et al. Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults , 2013, International Journal of Obesity.
[12] H. Fu,et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. , 2013, Cell metabolism.
[13] P. Scherer,et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. , 2013, Cell metabolism.
[14] R. Locksley,et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages , 2013, The Journal of experimental medicine.
[15] R. Seong,et al. A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells , 2012, Molecular and Cellular Biology.
[16] Gangyi Yang,et al. Liraglutide Increases FGF-21 Activity and Insulin Sensitivity in High Fat Diet and Adiponectin Knockdown Induced Insulin Resistance , 2012, PloS one.
[17] D. Drucker,et al. Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling , 2012, Diabetes.
[18] S. Balk,et al. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. , 2012, Immunity.
[19] G. Besra,et al. Natural killer T cells in adipose tissue prevent insulin resistance. , 2012, The Journal of clinical investigation.
[20] Liu Yang,et al. Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4* , 2012, The Journal of Biological Chemistry.
[21] B. Spiegelman,et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. , 2012, Genes & development.
[22] R. Locksley,et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis , 2011, Nature.
[23] S. Gortmaker,et al. Health and economic burden of the projected obesity trends in the USA and the UK , 2011, The Lancet.
[24] D. Doherty,et al. Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis , 2011, Diabetologia.
[25] K. Siminovitch,et al. Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells , 2010, Diabetologia.
[26] S. Enerbäck. The origins of brown adipose tissue. , 2009, The New England journal of medicine.
[27] J. Flier,et al. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. , 2009, Endocrinology.
[28] D. Doherty,et al. Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity , 2009, European journal of immunology.
[29] T. Elhadd,et al. Incretin based therapies for type 2 diabetes mellitus. , 2008, Journal of the Indian Medical Association.
[30] D. Drucker,et al. Biology of incretins: GLP-1 and GIP. , 2007, Gastroenterology.
[31] J. Gromada,et al. FGF-21 as a novel metabolic regulator. , 2005, The Journal of clinical investigation.
[32] A. Astrup,et al. The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes. , 2004, Diabetes care.
[33] Michael B Brenner,et al. CD1: antigen presentation and T cell function. , 2004, Annual review of immunology.
[34] Hitoshi Yamashita,et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese , 1997, nature.
[35] S. Bloom,et al. A role for central glucagon‐like peptide‐1 in temperature regulation , 1996, Neuroreport.
[36] D. Smith,et al. A role for glucagon-like peptide-1 in the central regulation of feeding , 1996, Nature.
[37] J. Himms-Hagen,et al. Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. , 1994, The American journal of physiology.
[38] L. Pénicaud,et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. , 1992, Journal of cell science.