Mechano-transduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer associated fibroblasts

[1]  Xiang-Dong Fu,et al.  Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling , 2012, Cell.

[2]  R. Hynes,et al.  The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain , 2012, Proceedings of the National Academy of Sciences.

[3]  Michael C. Ostrowski,et al.  Loss of fibroblast HIF-1α accelerates tumorigenesis. , 2012, Cancer research.

[4]  E. Sahai,et al.  Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts , 2012, Oncogene.

[5]  E. Brogi,et al.  Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. , 2011, Genes & development.

[6]  S. Bicciato,et al.  The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells , 2011, Cell.

[7]  E. Sahai,et al.  Cell communication networks in cancer invasion. , 2011, Current opinion in cell biology.

[8]  T. Okano,et al.  Hippo pathway regulation by cell morphology and stress fibers , 2011, Development.

[9]  R. Treisman,et al.  Nuclear transport of the serum response factor coactivator MRTF‐A is downregulated at tensional homeostasis , 2011, EMBO reports.

[10]  G. Charras,et al.  Experimental validation of atomic force microscopy-based cell elasticity measurements , 2011, Nanotechnology.

[11]  Bin Zhao,et al.  The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal , 2011, Nature Cell Biology.

[12]  G. Halder,et al.  Modulating F‐actin organization induces organ growth by affecting the Hippo pathway , 2011, The EMBO journal.

[13]  Nicola Elvassore,et al.  Role of YAP/TAZ in mechanotransduction , 2011, Nature.

[14]  Pedro Gaspar,et al.  Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila , 2011, Development.

[15]  Richard Superfine,et al.  The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins , 2011, Nature Cell Biology.

[16]  C. Tamm,et al.  Regulation of mouse embryonic stem cell self-renewal by a Yes–YAP–TEAD2 signaling pathway downstream of LIF , 2011, Journal of Cell Science.

[17]  D. Pan,et al.  The hippo signaling pathway in development and cancer. , 2010, Developmental cell.

[18]  Robert A. Weinberg,et al.  Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts , 2010, Proceedings of the National Academy of Sciences.

[19]  Jon C. Aster,et al.  Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells , 2010, Proceedings of the National Academy of Sciences.

[20]  Peter Olson,et al.  Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. , 2010, Cancer cell.

[21]  Richard Herrmann,et al.  IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients , 2010, BMC medicine.

[22]  Mikala Egeblad,et al.  Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling , 2009, Cell.

[23]  Walter Kolch,et al.  MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability , 2009, Molecular and Cellular Biology.

[24]  Metin N. Gurcan,et al.  Pten in Stromal Fibroblasts Suppresses Mammary Epithelial Tumors , 2009, Nature.

[25]  A. Ullrich,et al.  Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction. , 2009, Molecular cell.

[26]  Charles P. Lin,et al.  RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma. , 2009, Blood.

[27]  Zhengyu Zha,et al.  TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition* , 2009, Journal of Biological Chemistry.

[28]  J. Pollard,et al.  Microenvironmental regulation of metastasis , 2009, Nature Reviews Cancer.

[29]  Valerie M. Weaver,et al.  A tense situation: forcing tumour progression , 2009, Nature Reviews Cancer.

[30]  J. Erler,et al.  Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. , 2009, Cancer cell.

[31]  Jiandie D. Lin,et al.  TEAD mediates YAP-dependent gene induction and growth control. , 2008, Genes & development.

[32]  F. Pépin,et al.  Stromal gene expression predicts clinical outcome in breast cancer , 2008, Nature Medicine.

[33]  Y. Shaul,et al.  Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. , 2008, Molecular cell.

[34]  Jill P. Mesirov,et al.  GSEA-P: a desktop application for Gene Set Enrichment Analysis , 2007, Bioinform..

[35]  E. Sahai,et al.  Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells , 2007, Nature Cell Biology.

[36]  P. Brown,et al.  Transcriptional Program Induced by Wnt Protein in Human Fibroblasts Suggests Mechanisms for Cell Cooperativity in Defining Tissue Microenvironments , 2007, PloS one.

[37]  G. Feldmann,et al.  Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals , 2007, Cell.

[38]  Walter Kolch,et al.  RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. , 2007, Molecular cell.

[39]  Trevor Hastie,et al.  Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer , 2007, Genome Biology.

[40]  Mark W. Kieran,et al.  Identification of fibroblast heterogeneity in the tumor microenvironment , 2006, Cancer biology & therapy.

[41]  F. Holstege,et al.  Dissection of a metastatic gene expression signature into distinct components , 2006, Genome Biology.

[42]  Michael P. Sheetz,et al.  Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas , 2006, Cell.

[43]  Greg Finak,et al.  Gene expression signatures of morphologically normal breast tissue identify basal-like tumors , 2006, Breast Cancer Research.

[44]  S. Thorgeirsson,et al.  Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. , 2006, The Journal of clinical investigation.

[45]  Raghu Kalluri,et al.  Fibroblasts in cancer , 2006, Nature Reviews Cancer.

[46]  Jeffrey T. Chang,et al.  Oncogenic pathway signatures in human cancers as a guide to targeted therapies , 2006, Nature.

[47]  Cynthia A. Reinhart-King,et al.  Tensional homeostasis and the malignant phenotype. , 2005, Cancer cell.

[48]  H. Moses,et al.  Tumor-stroma interactions. , 2005, Current opinion in genetics & development.

[49]  R. Prywes,et al.  Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent , 2004, BMC Molecular Biology.

[50]  N. Carragher,et al.  Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. , 2004, Trends in cell biology.

[51]  Jeffrey W Pollard,et al.  Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. , 2003, The American journal of pathology.

[52]  K. Vousden.  HPV E6: ensuring all's well at the end. , 1996, Trends in microbiology.

[53]  R. Cardiff,et al.  Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease , 1992, Molecular and cellular biology.

[54]  H. Moses,et al.  Tumour stroma interactions , 2010 .

[55]  David Cameron,et al.  A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer , 2009, Nature Medicine.

[56]  T. Giordano,et al.  NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF , 2007, Nature Medicine.

[57]  J. Downward,et al.  Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. , 2003, Molecular cell.