Ribosomal S6 kinase and AKT phosphorylation as pharmacodynamic biomarkers in patients with myelodysplastic syndrome treated with RAD001.
暂无分享,去创建一个
J. Maciejewski | Y. Saunthararajah | A. Advani | R. Mahfouz | L. Rybicki | M. Sekeres | Barbara Tripp | M. Kalaycio | J. Bates
[1] L. Platanias,et al. An overview of the mTOR pathway as a target in cancer therapy , 2012, Expert opinion on therapeutic targets.
[2] M. Carroll,et al. Single-Cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts during a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy , 2011, Clinical Cancer Research.
[3] V. Rodrik-Outmezguine,et al. High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1 , 2011, Cell cycle.
[4] B. Manning,et al. Common corruption of the mTOR signaling network in human tumors , 2008, Oncogene.
[5] M. Konopleva,et al. Phase I/II Study of the Mammalian Target of Rapamycin Inhibitor Everolimus (RAD001) in Patients with Relapsed or Refractory Hematologic Malignancies , 2006, Clinical Cancer Research.
[6] A M Martelli,et al. Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia , 2006, Leukemia.
[7] Sanda Šulić,et al. Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. , 2005, Genes & development.
[8] N. Sonenberg,et al. Upstream and downstream of mTOR. , 2004, Genes & development.
[9] A. Barrett,et al. A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome. , 2003, Blood.
[10] L. Cantley,et al. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. , 2003, Cancer cell.
[11] J. Holland,et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] B. Cheson,et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. , 2000, Blood.
[13] T Hamblin,et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. , 1997, Blood.