In situ tensile testing of human aortas by time-resolved small-angle X-ray scattering.

The collagen diffraction patterns of human aortas under uniaxial tensile test conditions have been investigated by synchrotron small-angle X-ray scattering. Using a recently designed tensile testing device the orientation and d-spacing of the collagen fibers in the adventitial layer have been measured in situ with the macroscopic force and sample stretching under physiological conditions. The results show a direct relation between the orientation and extension of the collagen fibers on the nanoscopic level and the macroscopic stress and strain. This is attributed first to a straightening, second to a reorientation of the collagen fibers, and third to an uptake of the increasing loads by the collagen fibers.

[1]  G. Holzapfel,et al.  Anisotropic mechanical properties of tissue components in human atherosclerotic plaques. , 2004, Journal of biomechanical engineering.

[2]  M. Morocutti,et al.  Arrangement of microfibrils in collagen fibrils of tendons in the rat tail , 1983, Cell and Tissue Research.

[3]  Peter B. Canham,et al.  Collagen Biomechanics in Cerebral Arteries and Bifurcations Assessed by Polarizing Microscopy , 2003, Journal of Vascular Research.

[4]  R. Haut.  Biomechanics of Soft Tissue , 2002 .

[5]  F H Silver,et al.  Viscoelasticity of the vessel wall: the role of collagen and elastic fibers. , 2001, Critical reviews in biomedical engineering.

[6]  N. Sasaki,et al.  Time-resolved X-ray diffraction from tendon collagen during creep using synchrotron radiation. , 1999, Journal of biomechanics.

[7]  P. Canham,et al.  Collagen organization in the branching region of human brain arteries. , 1998, Stroke.

[8]  D W Hukins,et al.  Collagen orientation and molecular spacing during creep and stress-relaxation in soft connective tissues. , 1998, The Journal of experimental biology.

[9]  P. Fratzl,et al.  Fibrillar structure and mechanical properties of collagen. , 1998, Journal of structural biology.

[10]  A. Hammersley,et al.  A consensus model for molecular packing of type I collagen. , 1998, Journal of structural biology.

[11]  Analyse Your Tweets.  Connect. , 2020, Nature genetics.

[12]  P. Fratzl,et al.  A new molecular model for collagen elasticity based on synchrotron X-ray scattering evidence. , 1997, Biophysical journal.

[13]  N. Sasaki,et al.  Elongation mechanism of collagen fibrils and force-strain relations of tendon at each level of structural hierarchy. , 1996, Journal of biomechanics.

[14]  P. Canham,et al.  Three-dimensional collagen organization of human brain arteries at different transmural pressures. , 1995, Journal of vascular research.

[15]  H. Graafsma,et al.  Calibration and correction of distortions in two‐dimensional detector systemsa) , 1995 .

[16]  P. Canham,et al.  Effect of pressure on circumferential order of adventitial collagen in human brain arteries. , 1992, Canadian journal of physiology and pharmacology.

[17]  P. Canham,et al.  Medial collagen organization in human arteries of the heart and brain by polarized light microscopy. , 1991, Connective tissue research.

[18]  P. Canham,et al.  Measurements from light and polarised light microscopy of human coronary arteries fixed at distending pressure. , 1989, Cardiovascular research.

[19]  D A Parry,et al.  The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue. , 1988, Biophysical chemistry.

[20]  M. Morocutti,et al.  Differences in the fibril structure of corneal and tendon collagen. An electron microscopy and X-ray diffraction investigation. , 1986, Connective tissue research.

[21]  M. Koch,et al.  Stress-induced molecular rearrangement in tendon collagen. , 1985, Journal of molecular biology.

[22]  江橋 節郎,et al.  Handbook on synchrotron radiation , 1983 .

[23]  G. Jeronimidis,et al.  Mechanical behaviour of aortic tissue as a function of collagen orientation , 1980 .

[24]  D. Parry,et al.  Electron microscope evidence for an 80 Å unit in collagen fibrils , 1979, Nature.

[25]  J. Stephenson.  World health report. , 2004, Lancet.

[26]  R. Magno,et al.  Coronary heart disease , 1957 .