PARAMETERS OF PLASMIN SYSTEM DURING NORMAL PREGNANCY, LABOR AND PUERPERIUM, AND RELATION OF SEX HORMONES TO PLASMIN SYSTEM.

As to the change of factors relating to the plasmin system during pregnancy and puerperium, some conflicts have been found in the literature. This paper deals with the results of systemic analysis of this enzyme system, and the relation be-tween sex hormones and the factors is discussed. A marked elevation of factors of plasmin system during pregnancy was observed in fibrinogen, spontaneous caseinolytic activity of the euglobulin frac-tion, total plasmin and antiplasmin, but only a slight rise of fibrinolytic and fibrinogenolytic activities of the euglobulin. The administration of progesterone to human females produced marked increases in total plasmin, antiplasmin and spontaneous fibrinolytic activity of the euglobulin, on the other hand, irregular changes in fibrinogen and spontaneous caseinolytic activity of the euglobulin. Estrogen administration was responsible for an increase of spontaneous caseinolytic activity of the euglobulin and decreases in antiplasmin and spontaneous fibrinolytic activity of the euglobulin. However, essentially no change in fibrinogen and total plasmin was observed by the estrogen administration. These findings suggest that the close relation exists between sex hormones and plasmin system.