Microfluidic analog of the four-roll mill

We describe a microfluidic trap, for analysis of fluids and suspensions, that simulates the function of a four-roll mill, a rheological tool with adjustable flow type and rate. These flow characteristics were designed with the assistance of flow simulations and are measured here by micro-particle-image-velocimetry. This miniature device permits microscopic manipulations and measurements (e.g., of cells, particles, and drops) and it is capable of a range of flow types, including simple shear.

[1]  Gianni Astarita,et al.  Objective and generally applicable criteria for flow classification , 1979 .

[2]  D. J. Harrison,et al.  Clinical potential of microchip capillary electrophoresis systems , 1997, Electrophoresis.

[3]  A. Keller,et al.  Alignment of macromolecules in solution by elongational flow; a study of the effect of pure shear in a four roll mill , 1977 .

[4]  S. Quake,et al.  Microfluidic Memory and Control Devices , 2003, Science.

[5]  Jonathan Knight,et al.  Microfluidics: Honey, I shrunk the lab , 2002, Nature.

[6]  L. G. Leal,et al.  The coalescence of two equal-sized drops in a two-dimensional linear flow , 2001 .

[7]  Daniel T. Chiu,et al.  Microfluidic systems: High radial acceleration in microvortices , 2003, Nature.

[8]  L. G. Leal,et al.  An experimental investigation of drop deformation and breakup in steady, two-dimensional linear flows , 1986, Journal of Fluid Mechanics.

[9]  J. Higdon.  The kinematics of the four‐roll mill , 1993 .

[10]  S. Torza.  Shear‐induced crystallization of polymers. I. The four‐roller apparatus , 1975 .

[11]  H. Babcock,et al.  Dynamics and configurational fluctuations of single DNA molecules in linear mixed flows. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[12]  Steven Chu,et al.  Observation of Polymer Conformation Hysteresis in Extensional Flow , 2003, Science.

[13]  Y. T. Hu,et al.  Estimating surfactant surface coverage and decomposing its effect on drop deformation. , 2003, Physical review letters.

[14]  Darwin R. Reyes,et al.  Micro total analysis systems. 1. Introduction, theory, and technology. , 2002, Analytical chemistry.

[15]  L. G. Leal,et al.  A computer-controlled four-roll mill for investigations of particle and drop dynamics in two-dimensional linear shear flows , 1986, Journal of Fluid Mechanics.

[16]  Geoffrey Ingram Taylor,et al.  The formation of emulsions in definable fields of flow , 1934 .