The plasticity of alcohol addiction suggests novel approaches to pharmacological intervention

[1]  E. Carpenter-Hyland,et al.  Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spines , 2006, The European journal of neuroscience.

[2]  Megan K. Mulligan,et al.  Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[3]  B. Trapp,et al.  NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia , 2006, Nature.

[4]  M. P. van der Brug,et al.  Comparative gene expression in brain regions of human alcoholics , 2006, Genes, brain, and behavior.

[5]  R. Sprengel,et al.  Involvement of the AMPA Receptor GluR-C Subunit in Alcohol-Seeking Behavior and Relapse , 2006, The Journal of Neuroscience.

[6]  T. Krahe,et al.  Restoration of Neuronal Plasticity by a Phosphodiesterase Type 1 Inhibitor in a Model of Fetal Alcohol Exposure , 2006, The Journal of Neuroscience.

[7]  D. Attwell,et al.  NMDA receptors are expressed in oligodendrocytes and activated in ischaemia , 2005, Nature.

[8]  M. Salter,et al.  NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury , 2005, Nature.

[9]  K. Maiese,et al.  Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors. , 2005, Current neurovascular research.

[10]  B. McMillen,et al.  Effects of a metabotropic, mglu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats. , 2005, Alcohol and alcoholism.

[11]  A. Lawrence,et al.  The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems , 2005, Journal of Pharmacology and Experimental Therapeutics.

[12]  D. Lovinger,et al.  Laboratory models of alcoholism: treatment target identification and insight into mechanisms , 2005, Nature Neuroscience.

[13]  E. Nestler Is there a common molecular pathway for addiction? , 2005, Nature Neuroscience.

[14]  P. Kalivas How do we determine which drug-induced neuroplastic changes are important? , 2005, Nature Neuroscience.

[15]  K. Vinod,et al.  Endocannabinoid lipids and mediated system: implications for alcoholism and neuropsychiatric disorders. , 2005, Life sciences.

[16]  C. O'brien Anticraving medications for relapse prevention: a possible new class of psychoactive medications. , 2005, The American journal of psychiatry.

[17]  P. Worley,et al.  Homer2 Is Necessary for EtOH-Induced Neuroplasticity , 2005, The Journal of Neuroscience.

[18]  M. Olive mGlu5 Receptors: Neuroanatomy, Pharmacology, and Role in Drug Addiction , 2005 .

[19]  J. Meldolesi,et al.  Key Role of the Postsynaptic Density Scaffold Proteins Shank and Homer in the Functional Architecture of Ca2+ Homeostasis at Dendritic Spines in Hippocampal Neurons , 2005, The Journal of Neuroscience.

[20]  L. Chandler,et al.  Acute ethanol inhibits extracellular signal-regulated kinase, protein kinase B, and adenosine 3':5'-cyclic monophosphate response element binding protein activity in an age- and brain region-specific manner. , 2005, Alcoholism, clinical and experimental research.

[21]  M. P. van der Brug,et al.  Alcohol‐responsive genes in the frontal cortex and nucleus accumbens of human alcoholics , 2005, Journal of neurochemistry.

[22]  M. P. van der Brug,et al.  Alcohol‐responsive genes in the frontal cortex and nucleus accumbens of human alcoholics , 2005 .

[23]  N. Volkow,et al.  Unmanageable Motivation in Addiction: A Pathology in Prefrontal-Accumbens Glutamate Transmission , 2005, Neuron.

[24]  D. Overstreet,et al.  The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats , 2005, Psychopharmacology.

[25]  Y. Shaham,et al.  Central amygdala ERK signaling pathway is critical to incubation of cocaine craving , 2005, Nature Neuroscience.

[26]  P. Janak,et al.  The mGluR5 Antagonist 6-Methyl-2-(phenylethynyl)pyridine Decreases Ethanol Consumption via a Protein Kinase Cϵ-Dependent Mechanism , 2005, Molecular Pharmacology.

[27]  Bryan Kolb,et al.  Structural plasticity associated with exposure to drugs of abuse , 2004, Neuropharmacology.

[28]  M. Bennett,et al.  Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression , 2004, The Journal of Neuroscience.

[29]  K. Harris,et al.  Age-dependence in the homeostatic upregulation of hippocampal dendritic spine number during blocked synaptic transmission , 2004, Neuropharmacology.

[30]  Takeharu Nagai,et al.  Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity , 2004, Nature Neuroscience.

[31]  M. Sheng,et al.  PDZ domain proteins of synapses , 2004, Nature Reviews Neuroscience.

[32]  E. Carpenter-Hyland,et al.  Chronic Ethanol Induces Synaptic But Not Extrasynaptic Targeting of NMDA Receptors , 2004, The Journal of Neuroscience.

[33]  K. Iwamoto,et al.  Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics , 2004, Neuroscience Research.

[34]  D. Ron Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol , 2004, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[35]  B. Grant,et al.  The 12-Month Prevalence and Trends in DSM–IV Alcohol Abuse and Dependence , 2004, Drug and alcohol dependence.

[36]  K. Mikoshiba,et al.  Differential expression of Homer family proteins in the developing mouse brain , 2004, The Journal of comparative neurology.

[37]  J. Nagy The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence. , 2004, Current drug targets. CNS and neurological disorders.

[38]  P. Kenny,et al.  The ups and downs of addiction: role of metabotropic glutamate receptors. , 2004, Trends in pharmacological sciences.

[39]  R. Spanagel,et al.  mGluR5 Antagonist MPEP Reduces Ethanol-Seeking and Relapse Behavior , 2004, Neuropsychopharmacology.

[40]  D. Manahan‐Vaughan,et al.  Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. , 2004, Cerebral cortex.

[41]  Heike Hering,et al.  Activity-Dependent Redistribution and Essential Role of Cortactin in Dendritic Spine Morphogenesis , 2003, The Journal of Neuroscience.

[42]  R. Petralia,et al.  Trafficking of NMDA receptors. , 2003, Annual review of pharmacology and toxicology.

[43]  M. Ehlers,et al.  Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors , 2003, Neuropharmacology.

[44]  N. W. Pedigo,et al.  The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors. , 2003, Alcoholism, clinical and experimental research.

[45]  A. Matus,et al.  Activity-induced targeting of profilin and stabilization of dendritic spine morphology , 2003, Nature Neuroscience.

[46]  D. Ron,et al.  Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. , 2003, Alcoholism, clinical and experimental research.

[47]  Kenji Yamamoto,et al.  Inhibition of Dendritic Spine Morphogenesis and Synaptic Transmission by Activity-Inducible Protein Homer1a , 2003, The Journal of Neuroscience.

[48]  C. Thornton,et al.  H-Ras Modulates N-Methyl-D-aspartate Receptor Function via Inhibition of Src Tyrosine Kinase Activity* , 2003, Journal of Biological Chemistry.

[49]  P. Soubrié,et al.  Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice , 2003, Neuroscience Letters.

[50]  W. Abraham,et al.  Long-term regulation of n-methyl-d-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity , 2003, Neuroscience.

[51]  Yasuhiko Ohta,et al.  Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo , 2003, Neuron.

[52]  A. Triller,et al.  The role of receptor diffusion in the organization of the postsynaptic membrane , 2003, Nature Reviews Neuroscience.

[53]  J. Magee,et al.  Mechanism of the distance‐dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons , 2003, The Journal of physiology.

[54]  D. Ron,et al.  Pituitary Adenylate Cyclase-activating Polypeptide (PACAP(1–38)) Enhances N-Methyl-d-aspartate Receptor Function and Brain-derived Neurotrophic Factor Expression via RACK1* , 2003, The Journal of Biological Chemistry.

[55]  K. Mikoshiba,et al.  Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons , 2003, Molecular and Cellular Neuroscience.

[56]  C. Vadász,et al.  Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol‐induced dopamine release in the nucleus accumbens , 2003, Journal of neurochemistry.

[57]  R. Carroll,et al.  NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity , 2002, Trends in Neurosciences.

[58]  Pascal Jourdain,et al.  LTP, memory and structural plasticity. , 2002, Current molecular medicine.

[59]  O. Vitolo,et al.  Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[60]  D. Balschun,et al.  Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats , 2002, Pharmacology Biochemistry and Behavior.

[61]  K. E. Smith,et al.  Regulation of A-Kinase Anchoring Protein 79/150–cAMP-Dependent Protein Kinase Postsynaptic Targeting by NMDA Receptor Activation of Calcineurin and Remodeling of Dendritic Actin , 2002, The Journal of Neuroscience.

[62]  A. Fienberg,et al.  DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens , 2002, Nature Neuroscience.

[63]  J. Ballenger,et al.  The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trial , 2002, Journal of General Internal Medicine.

[64]  G. Westbrook,et al.  Mobile NMDA Receptors at Hippocampal Synapses , 2002, Neuron.

[65]  A. Bonci,et al.  NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[66]  T. Schikorski,et al.  Inactivity Produces Increases in Neurotransmitter Release and Synapse Size , 2001, Neuron.

[67]  D. Lovinger,et al.  Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. , 2001, Journal of neurophysiology.

[68]  Yasushi Miyashita,et al.  Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons , 2001, Nature Neuroscience.

[69]  R A Challiss,et al.  Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. , 2001, The Biochemical journal.

[70]  M. Ichikawa,et al.  Cellular localization of metabotropic glutamate receptors mGluR1, 2/3, 5 and 7 in the main and accessory olfactory bulb of the rat , 2001, Neuroscience Letters.

[71]  G Bernardi,et al.  Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons , 2001, Neuroscience.

[72]  S. Traynelis,et al.  Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function , 2001, The Journal of Neuroscience.

[73]  W. Spooren,et al.  Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders. , 2001, Trends in pharmacological sciences.

[74]  G. Westbrook,et al.  A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux , 2001, Nature Neuroscience.

[75]  Mark Farrant,et al.  NMDA receptor subunits: diversity, development and disease , 2001, Current Opinion in Neurobiology.

[76]  F. Gasparini,et al.  An activity‐dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors , 2001, The European journal of neuroscience.

[77]  R. Harris,et al.  Gene expression in human alcoholism: microarray analysis of frontal cortex. , 2000, Alcoholism, clinical and experimental research.

[78]  P. Popoli,et al.  The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors , 2000, Neuroreport.

[79]  Y. Smith,et al.  Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus , 2000, The Journal of Neuroscience.

[80]  S. Halpain,et al.  Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[81]  B. Basavarajappa,et al.  Distinct differences in the cannabinoid receptor binding in the brain of C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption , 2000, Journal of neuroscience research.

[82]  G. Koob,et al.  Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers. , 1999, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[83]  R. Spanagel,et al.  Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats. , 1999, Brain research. Molecular brain research.

[84]  K. Harris,et al.  Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated , 1999, Nature Neuroscience.

[85]  F. Bordi,et al.  Group I metabotropic glutamate receptors: implications for brain diseases , 1999, Progress in Neurobiology.

[86]  P. Greengard,et al.  Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. , 1999, Neuron.

[87]  I. McGregor,et al.  Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist. , 1999, European journal of pharmacology.

[88]  R. Malenka,et al.  An Immunocytochemical Assay for Activity‐Dependent Redistribution of Glutamate Receptors from the Postsynaptic Plasma Membrane , 1999, Annals of the New York Academy of Sciences.

[89]  I. McGregor,et al.  The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716 , 1999, Psychopharmacology.

[90]  S. Heinemann,et al.  Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems , 1999, Nature Neuroscience.

[91]  R. Dingledine,et al.  The glutamate receptor ion channels. , 1999, Pharmacological reviews.

[92]  B. Basavarajappa,et al.  Chronic Ethanol Increases the Cannabinoid Receptor Agonist Anandamide and Its Precursor N‐Arachidonoylphosphatidylethanolamine in SK ‐ N ‐ SH Cells , 1999, Journal of neurochemistry.

[93]  B. Basavarajappa,et al.  Down-regulation of cannabinoid receptor agonist-stimulated [ 35 S ]GTPγS binding in synaptic plasma membrane from chronic ethanol exposed mouse , 1999, Brain Research.

[94]  C. Breivogel,et al.  The Functional Neuroanatomy of Brain Cannabinoid Receptors , 1998, Neurobiology of Disease.

[95]  F. Fadda,et al.  Chronic ethanol consumption:from neuroadaptation to neurodegeneration , 1998, Progress in Neurobiology.

[96]  R. Nicoll,et al.  Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[97]  T. Cooper,et al.  Chronic ethanol administration down-regulates cannabinoid receptors in mouse brain synaptic plasma membrane , 1998, Brain Research.

[98]  C. Pomerleau,et al.  Nicotine dependence and withdrawal in alcoholic and nonalcoholic ever-smokers. , 1997, Journal of substance abuse treatment.

[99]  J. Roder,et al.  Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP , 1997, The Journal of Neuroscience.

[100]  C P Ponting,et al.  PDZ Domains: Targeting signalling molecules to sub‐membranous sites , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[101]  L. J. Chandler,et al.  Chronic ethanol increases N-methyl-D-aspartate-stimulated nitric oxide formation but not receptor density in cultured cortical neurons. , 1997, Molecular pharmacology.

[102]  G. Freund,et al.  Glutamate receptors in the frontal cortex of alcoholics. , 1996, Alcoholism, clinical and experimental research.

[103]  B. Sakmann,et al.  Developmental and regional expression in the rat brain and functional properties of four NMDA receptors , 1994, Neuron.

[104]  W. R. Lieb,et al.  Molecular and cellular mechanisms of general anaesthesia , 1994, Nature.

[105]  S. Munro,et al.  Molecular characterization of a peripheral receptor for cannabinoids , 1993, Nature.

[106]  P. Bregestovski,et al.  Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses. , 1991, European journal of pharmacology.

[107]  R. G. Walton Smoking and alcoholism: a brief report. , 1972, The American journal of psychiatry.

[108]  R. Messing,et al.  Intracellular signaling pathways that regulate behavioral responses to ethanol. , 2006, Pharmacology & therapeutics.

[109]  M. Miles,et al.  The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice , 2005, Psychopharmacology.

[110]  Joseph E LeDoux,et al.  Structural plasticity and memory , 2004, Nature Reviews Neuroscience.

[111]  David G Standaert,et al.  Dopamine D1-dependent trafficking of striatal N-methyl-D-aspartate glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32. , 2004, Molecular pharmacology.

[112]  F. Iasevoli,et al.  The Homer family and the signal transduction system at glutamatergic postsynaptic density: potential role in behavior and pharmacotherapy. , 2003, Psychopharmacology bulletin.

[113]  R. Yuste,et al.  Morphological changes in dendritic spines associated with long-term synaptic plasticity. , 2001, Annual review of neuroscience.

[114]  M. Ticku,et al.  Regulation of NMDA receptors by ethanol. , 2000, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[115]  J. Woodward Ethanol and NMDA receptor signaling. , 2000, Critical reviews in neurobiology.

[116]  S. Heinemann,et al.  Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. , 1998, Molecular pharmacology.

[117]  H. Becker Kindling in Alcohol Withdrawal , 1998, Alcohol health and research world.

[118]  B. Grant,et al.  Family history of alcoholism and gender: their combined effects on DSM-IV alcohol dependence and major depression. , 1998, Journal of studies on alcohol.

[119]  J. Pin,et al.  Pharmacology and functions of metabotropic glutamate receptors. , 1997, Annual review of pharmacology and toxicology.

[120]  F. F. Weight,et al.  Lipid vs protein theories of alcohol action in the nervous system. , 1996, Annual review of pharmacology and toxicology.