Neutron diffraction study of antibacterial bioactive calcium silicate sol-gel glasses containing silver

Bioactive sol-gel calcia-silica glasses can regenerate damaged or diseased bones due to their ability to stimulate bone growth. This capability is related to the formation of a hydroxyapatite layer on the glass surface, which bonds with bone, and the release of soluble silica and calcium ions in the body fluid which accelerates bone growth. The addition of silver ions imbues the glass with antibacterial properties due to the release of antibacterial Ag+ ion. The antibacterial activity is therefore closely dependent on the dissolution properties of the glasses which in turn are related to their atomic-level structure. Structural characterisation of the glasses at the atomic level is therefore essential in order to investigate and control the antibacterial properties of the glass. We have used neutron diffraction to investigate the structure of silver-containing calcia-silica sol-gel bioactive glasses with different Ag2O loading (0, 2, 4, 6 mol %). The presence of the silver had little effect on the host glass structure, although some silver metal nanoparticles were present. Results agreed with previous computer simulations.

[1]  Ion Petre,et al.  Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems , 2017, Advanced healthcare materials.

[2]  C. Sutcliffe,et al.  Atomic Layer Deposition of a Silver Nanolayer on Advanced Titanium Orthopedic Implants Inhibits Bacterial Colonization and Supports Vascularized de Novo Bone Ingrowth , 2017, Advanced healthcare materials.

[3]  Julian R. Jones,et al.  Bioglass and Bioactive Glasses and Their Impact on Healthcare , 2016 .

[4]  D. S. Arora,et al.  Magnesium and silver doped CaO–Na2O–SiO2–P2O5 bioceramic nanoparticles as implant materials , 2016 .

[5]  Julian R. Jones,et al.  Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships , 2016, Journal of Sol-Gel Science and Technology.

[6]  Julian R. Jones,et al.  Compressive Strength of Bioactive Sol–Gel Glass Foam Scaffolds , 2016 .

[7]  F. Baino,et al.  Antibacterial Bioglass-Derived Scaffolds: Innovative Synthesis Approach and Characterization , 2016 .

[8]  Julian R. Jones,et al.  Controlling particle size in the Stöber process and incorporation of calcium. , 2016, Journal of colloid and interface science.

[9]  Jonathan C. Knowles,et al.  Sol-gel based materials for biomedical applications , 2016 .

[10]  S. Das,et al.  Antibacterial Effects of Biosynthesized Silver Nanoparticles on Surface Ultrastructure and Nanomechanical Properties of Gram-Negative Bacteria viz. Escherichia coli and Pseudomonas aeruginosa. , 2016, ACS applied materials & interfaces.

[11]  Julian R. Jones,et al.  Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair , 2016 .

[12]  Julian R. Jones,et al.  Bioactive Glasses: Frontiers and Challenges , 2015, Front. Bioeng. Biotechnol..

[13]  M. Catauro,et al.  Investigation on bioactivity, biocompatibility, thermal behavior and antibacterial properties of calcium silicate glass coatings containing Ag , 2015 .

[14]  Julian R. Jones,et al.  A multinuclear solid state NMR spectroscopic study of the structural evolution of disordered calcium silicate sol-gel biomaterials. , 2015, Physical chemistry chemical physics : PCCP.

[15]  R. Burnap.  Systems and Photosystems: Cellular Limits of Autotrophic Productivity in Cyanobacteria , 2014, Front. Bioeng. Biotechnol..

[16]  R. Moss,et al.  NXFit: a program for simultaneously fitting X‐ray and neutron diffraction pair‐distribution functions to provide optimized structural parameters , 2014 .

[17]  M. Stevens,et al.  Cotton-wool-like bioactive glasses for bone regeneration. , 2014, Acta biomaterialia.

[18]  Richard A. Martin,et al.  Structural characterization of titanium-doped Bioglass using isotopic substitution neutron diffraction. , 2012, Physical chemistry chemical physics : PCCP.

[19]  Richard A. Martin,et al.  An examination of the calcium and strontium site distribution in bioactive glasses through isomorphic neutron diffraction, X-ray diffraction, EXAFS and multinuclear solid state NMR , 2012 .

[20]  Richard A. Martin,et al.  A structural investigation of the alkali metal site distribution within bioactive glass using neutron diffraction and multinuclear solid state NMR. , 2012, Physical chemistry chemical physics : PCCP.

[21]  Peng Chang,et al.  Morphology-controlled synthesis of monodisperse silver spheres via a solvothermal method , 2011 .

[22]  Julian R. Jones,et al.  Characterisation of the inhomogeneity of sol–gel-derived SiO2–CaO bioactive glass and a strategy for its improvement , 2010 .

[23]  L. N. Furini,et al.  Synthesis and thermal properties of nanoparticles of bioactive glasses containing silver , 2009 .

[24]  Julian R. Jones,et al.  Nanostructure evolution and calcium distribution in sol-gel derived bioactive glass , 2009 .

[25]  X. C. Yang,et al.  Silver structure environments in ion-exchanged silicate glasses studied by X-ray absorption fine structure. , 2009, Journal of nanoscience and nanotechnology.

[26]  Jonathan C. Knowles,et al.  Structural Characteristics of Antibacterial Bioresorbable Phosphate Glass , 2008 .

[27]  Julian R. Jones,et al.  In vitro changes in the structure of a bioactive calcia-silica sol-gel glass explored using isotopic substitution in neutron diffraction , 2007 .

[28]  Julian R. Jones,et al.  Controlling ion release from bioactive glass foam scaffolds with antibacterial properties , 2006, Journal of materials science. Materials in medicine.

[29]  L. Hench,et al.  The use of advanced diffraction methods in the study of the structure of a bioactive calcia: silica sol-gel glass , 2006 .

[30]  G. Mountjoy,et al.  Modeling the Local Atomic Structure of Bioactive Sol−Gel-Derived Calcium Silicates , 2006 .

[31]  Alex C. Hannon,et al.  Results on disordered materials from the GEneral Materials diffractometer, GEM, at ISIS ☆ , 2005 .

[32]  Julian R. Jones,et al.  Indirect Cytotoxicity Evaluation of Silver Doped Bioglass Ag-S70C30 on Human Primary Keratinocytes , 2005 .

[33]  Julie E. Gough,et al.  Antimicrobial Macroporous Gel-Glasses: Dissolution and Cytotoxicity , 2003 .

[34]  L L Hench,et al.  In vitro dissolution of melt-derived 45S5 and sol-gel derived 58S bioactive glasses. , 2002, Journal of biomedical materials research.

[35]  Larry L. Hench,et al.  Broad-Spectrum Bactericidal Activity of Ag2O-Doped Bioactive Glass , 2002, Antimicrobial Agents and Chemotherapy.

[36]  L. Hench,et al.  Bacteriostatic action of a novel four-component bioactive glass. , 2000, Journal of biomedical materials research.

[37]  H. Kozuka,et al.  Antibacterial silver-containing silica glass prepared by sol-gel method. , 2000, Biomaterials.

[38]  J. W. Halley,et al.  Atomic structure of solid and liquid polyethylene oxide , 1998 .

[39]  A. Wright.  Neutron scattering from vitreous silica. V. The structure of vitreous silica: What have we learned from 60 years of diffraction studies? , 1994 .

[40]  A. Dent,et al.  Sodium and silver environments and ion-exchange processes in silicate and aluminosilicate glasses , 1993 .

[41]  Q. Myrvik,et al.  Antibiotic resistance of biomaterial-adherent coagulase-negative and coagulase-positive staphylococci. , 1990, Clinical orthopaedics and related research.

[42]  J. Stebbins.  Effects of temperature and composition on silicate glass structure and dynamics: SI-29 NMR results , 1988 .

[43]  A. Gristina,et al.  Biomaterial-centered infection: microbial adhesion versus tissue integration. , 1987, Science.

[44]  T. Yamanaka,et al.  The structure and polytypes of α-CaSiO3 (pseudowollastonite) , 1981 .

[45]  Larry L. Hench,et al.  Bonding mechanisms at the interface of ceramic prosthetic materials , 1971 .

[46]  E. Lorch.  Neutron diffraction by germania, silica and radiation-damaged silica glasses , 1969 .

[47]  T. Webster,et al.  Enhanced apatite-forming ability and antibacterial activity of porous anodic alumina embedded with CaO-SiO2-Ag2O bioactive materials. , 2016, Materials science & engineering. C, Materials for biological applications.

[48]  A. Clark,et al.  Opening paper 2015-Some comments on Bioglass : Four Eras of Discovery and Development , 2015 .

[49]  Julian R Jones,et al.  Review of bioactive glass: from Hench to hybrids. , 2013, Acta biomaterialia.

[50]  G. C. Wall.  THE SOL-GEL PROCESS , 1965 .