a-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect.

BACKGROUND AND OBJECTIVE The aim of the study is to compare the effects of multiple sessions of cathodal (c-tDCS) or anodal tDCS (a-tDCS) in modulating the beneficial effects of prism adaptation (PA) treatment in neglect patients. METHODS 30 neglect patients were submitted to 10 daily sessions of PA treatment. Patients were pseudo-randomly divided into 3 groups. In the c-tDCS-group, each PA session was coupled with 20 minutes of cathodal stimulation of the left, intact PPC; in the a-tDCS-group, anodal stimulation was applied to PPC of the damaged hemisphere; in the Sham group, sham stimulation was applied. Neglect was evaluated before and after treatment with the Behavioral Inattention Test. RESULTS Combined tDCS-PA treatment induced stronger neglect improvement in the a-tDCSgroup as compared to the Sham group. No improvement was found in the c-tDCS group, with respect to that normally induced by PA and found in the Sham group. CONCLUSIONS c-tDCS abolished neglect amelioration after PA, possibly because stimulation affected the sensorimotor network controlling prism adaptation. Instead, a-tDCS PPC boosted neglect amelioration after PA probably thanks to increased excitability of residual tissue in the lesioned hemisphere, which in turn might reduce dysfunctional over-excitability of the intact hemisphere.

[1]  Nadia Bolognini,et al.  Improving ideomotor limb apraxia by electrical stimulation of the left posterior parietal cortex. , 2015, Brain : a journal of neurology.

[2]  O. Carter,et al.  Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: A systematic review , 2015, Neuropsychologia.

[3]  Hidenao Fukuyama,et al.  The anodal tDCS over the left posterior parietal cortex enhances attention toward a focus word in a sentence , 2014, Front. Hum. Neurosci..

[4]  L. Jäncke,et al.  Treatment of visuospatial neglect with biparietal tDCS and cognitive training: a single-case study , 2014, Front. Syst. Neurosci..

[5]  N. Bolognini,et al.  Neuromodulation of parietal and motor activity affects motor planning and execution , 2014, Cortex.

[6]  Y. Kim,et al.  Effects of dual transcranial direct current stimulation on post-stroke unilateral visuospatial neglect , 2013, Neuroscience Letters.

[7]  N. Bolognini,et al.  Motor and parietal cortex stimulation for phantom limb pain and sensations , 2013, PAIN®.

[8]  A. Pollock,et al.  Cognitive rehabilitation for spatial neglect following stroke. , 2013, The Cochrane database of systematic reviews.

[9]  R. Boston,et al.  Advancing the Science of Spatial Neglect Rehabilitation: An Improved Statistical Approach with Mixed Linear Modeling , 2013, Front. Hum. Neurosci..

[10]  Marcel Kinsbourne,et al.  Orientational bias model of unilateral neglect: Evidence from attentional gradients within hemispace. , 2013 .

[11]  M. Nitsche,et al.  Partially non‐linear stimulation intensity‐dependent effects of direct current stimulation on motor cortex excitability in humans , 2013, The Journal of physiology.

[12]  Patrik Vuilleumier,et al.  Prism adaptation enhances activity of intact fronto-parietal areas in both hemispheres in neglect patients , 2013, Cortex.

[13]  Hugo Théoret,et al.  Anodal transcranial direct current stimulation modulates GABAB-related intracortical inhibition in the M1 of healthy individuals , 2013, Neuroreport.

[14]  S. Kautz,et al.  Review of Transcranial Direct Current Stimulation in Poststroke Recovery , 2013, Topics in stroke rehabilitation.

[15]  F. Fregni,et al.  Systematic Review of Parameters of Stimulation, Clinical Trial Design Characteristics, and Motor Outcomes in Non-Invasive Brain Stimulation in Stroke , 2012, Front. Psychiatry.

[16]  Louise Marston,et al.  Rethinking Clinical Trials of Transcranial Direct Current Stimulation: Participant and Assessor Blinding Is Inadequate at Intensities of 2mA , 2012, PloS one.

[17]  Andrea Serino,et al.  Suppression of premotor cortex disrupts motor coding of peripersonal space , 2012, NeuroImage.

[18]  J. C. Basso,et al.  Prism adaptation for spatial neglect after stroke: translational practice gaps , 2012, Nature Reviews Neurology.

[19]  Lena Sarp,et al.  The fade-in – Short stimulation – Fade out approach to sham tDCS – Reliable at 1 mA for naïve and experienced subjects, but not investigators , 2012, Brain Stimulation.

[20]  J. Lefaucheur,et al.  Stroke rehabilitation using noninvasive cortical stimulation: motor deficit , 2012, Expert review of neurotherapeutics.

[21]  J. Lefaucheur,et al.  Stroke rehabilitation using noninvasive cortical stimulation: hemispatial neglect , 2012, Expert review of neurotherapeutics.

[22]  A. Avenanti,et al.  Low-frequency rTMS promotes use-dependent motor plasticity in chronic stroke , 2012, Neurology.

[23]  C. Caltagirone,et al.  Theta-burst stimulation of the left hemisphere accelerates recovery of hemispatial neglect , 2012, Neurology.

[24]  Donel M. Martin,et al.  Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial , 2012, British Journal of Psychiatry.

[25]  L. Provinciali,et al.  Electrical stimulation over the left inferior frontal gyrus (IFG) determines long-term effects in the recovery of speech apraxia in three chronic aphasics , 2011, Behavioural Brain Research.

[26]  M. Koslowsky,et al.  tDCS polarity effects in motor and cognitive domains: a meta-analytical review , 2011, Experimental Brain Research.

[27]  Nadia Bolognini,et al.  Neurophysiological and Behavioral Effects of tDCS Combined With Constraint-Induced Movement Therapy in Poststroke Patients , 2011, Neurorehabilitation and neural repair.

[28]  E. Làdavas,et al.  Neglect rehabilitation by prism adaptation: Different procedures have different impacts , 2011, Neuropsychologia.

[29]  Julie M. Baker,et al.  Transcranial Direct Current Stimulation Improves Naming Reaction Time in Fluent Aphasia: A Double-Blind, Sham-Controlled Study , 2011, Stroke.

[30]  A. Cantagallo,et al.  Selective and integrated rehabilitation programs for disturbances of visual/spatial attention and executive function after brain damage: a neuropsychological evidence-based review. , 2011, European journal of physical and rehabilitation medicine.

[31]  M. Nitsche,et al.  Physiological Basis of Transcranial Direct Current Stimulation , 2011, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[32]  A. Antal,et al.  Electrode-distance dependent after-effects of transcranial direct and random noise stimulation with extracephalic reference electrodes , 2010, Clinical Neurophysiology.

[33]  G. Schlaug,et al.  Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients , 2010, Neurology.

[34]  A. Maravita,et al.  Rehabilitating patients with left spatial neglect by prism exposure during a visuomotor activity. , 2010, Neuropsychology.

[35]  T. Mima,et al.  Recovery of upper-limb function due to enhanced use-dependent plasticity in chronic stroke patients. , 2010, Brain : a journal of neurology.

[36]  Min-Kyun Oh,et al.  Effect of Transcranial Direct Current Stimulation on Motor Recovery in Patients with Subacute Stroke , 2010, American journal of physical medicine & rehabilitation.

[37]  T. Habekost,et al.  Finding Wally: Prism adaptation improves visual search in chronic neglect , 2010, Neuropsychologia.

[38]  Chris Rorden,et al.  Using Transcranial Direct-Current Stimulation to Treat Stroke Patients With Aphasia , 2010, Stroke.

[39]  N. Paik,et al.  Repetitive transcranial magnetic stimulation to hemispatial neglect in patients after stroke: an open-label pilot study. , 2010, Journal of rehabilitation medicine.

[40]  Iain D Gilchrist,et al.  A single blinded randomised controlled pilot trial of prism adaptation for improving self-care in stroke patients with neglect , 2010, Neuropsychological rehabilitation.

[41]  Gin S Malhi,et al.  A double-blind, sham-controlled trial of transcranial direct current stimulation for the treatment of depression. , 2010, The international journal of neuropsychopharmacology.

[42]  E. Khedr,et al.  Role of 1 and 3 Hz repetitive transcranial magnetic stimulation on motor function recovery after acute ischaemic stroke , 2009, European journal of neurology.

[43]  G. Fink,et al.  Bidirectional alterations of interhemispheric parietal balance by non-invasive cortical stimulation. , 2009, Brain : a journal of neurology.

[44]  Christian Grefkes,et al.  Differential effects of high‐frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke , 2009, Annals of neurology.

[45]  Dario Cazzoli,et al.  One Session of Repeated Parietal Theta Burst Stimulation Trains Induces Long-Lasting Improvement of Visual Neglect , 2009, Stroke.

[46]  Andrea Serino,et al.  Effectiveness of Prism Adaptation in Neglect Rehabilitation: A Controlled Trial Study , 2009, Stroke.

[47]  Yuejia Luo,et al.  Low-frequency transcranial magnetic stimulation for visual spatial neglect: a pilot study. , 2009, Journal of rehabilitation medicine.

[48]  Patrik Vuilleumier,et al.  Dynamic Changes in Brain Activity during Prism Adaptation , 2009, The Journal of Neuroscience.

[49]  Myoung-Hwan Ko,et al.  Improvement of visual scanning after DC brain polarization of parietal cortex in stroke patients with spatial neglect , 2008, Neuroscience Letters.

[50]  J. Rothwell,et al.  Hyperexcitability of parietal-motor functional connections in the intact left-hemisphere of patients with neglect. , 2008, Brain : a journal of neurology.

[51]  Pablo Celnik,et al.  Controversy: Noninvasive and invasive cortical stimulation show efficacy in treating stroke patients , 2008, Brain Stimulation.

[52]  D. Leys,et al.  Stroke: the bare essentials. , 2008, Practical neurology.

[53]  L. Cohen,et al.  Transcranial direct current stimulation: State of the art 2008 , 2008, Brain Stimulation.

[54]  Eve Dupierrix,et al.  Experimental remission of unilateral spatial neglect , 2007, Neuropsychologia.

[55]  E. Làdavas,et al.  Neglect treatment by prism adaptation: What recovers and for how long , 2007, Neuropsychological rehabilitation.

[56]  A. Antal,et al.  Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients , 2007, Brain Research Bulletin.

[57]  Y. Rossetti,et al.  Visuo-spatial neglect: A systematic review of current interventions and their effectiveness , 2006, Neuroscience & Biobehavioral Reviews.

[58]  E. Làdavas,et al.  Mechanisms underlying neglect recovery after prism adaptation , 2006, Neuropsychologia.

[59]  Gordon M. Redding,et al.  Prism adaptation and unilateral neglect: Review and analysis , 2006, Neuropsychologia.

[60]  John Rothwell,et al.  Does brain stimulation after stroke have a future? , 2006, Current opinion in neurology.

[61]  L. Cohen,et al.  Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? , 2006, The Lancet Neurology.

[62]  Steven D. Freedman,et al.  A Sham-Controlled Trial of a 5-Day Course of Repetitive Transcranial Magnetic Stimulation of the Unaffected Hemisphere in Stroke Patients , 2006, Stroke.

[63]  Y. Rossetti,et al.  Functional anatomy of the therapeutic effects of prism adaptation on left neglect , 2006, Neurology.

[64]  M. Hallett,et al.  Repetitive Transcranial Magnetic Stimulation–Induced Corticomotor Excitability and Associated Motor Skill Acquisition in Chronic Stroke , 2006, Stroke.

[65]  L. Cohen,et al.  Transcranial DC stimulation (tDCS): A tool for double-blind sham-controlled clinical studies in brain stimulation , 2006, Clinical Neurophysiology.

[66]  Ichiro Watanabe,et al.  Repetitive Transcranial Magnetic Stimulation of Contralesional Primary Motor Cortex Improves Hand Function After Stroke , 2005, Stroke.

[67]  A. Priori,et al.  Non‐synaptic mechanisms underlie the after‐effects of cathodal transcutaneous direct current stimulation of the human brain , 2005, The Journal of physiology.

[68]  Sergio P. Rigonatti,et al.  Transcranial direct current stimulation of the unaffected hemisphere in stroke patients , 2005, Neuroreport.

[69]  S. Clarke,et al.  EFNS guidelines on cognitive rehabilitation: report of an EFNS task force , 2005, European journal of neurology.

[70]  J. Rothwell,et al.  Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke , 2005, Neurology.

[71]  Sergio P. Rigonatti,et al.  A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients , 2005, Neurology.

[72]  Elisabetta Làdavas,et al.  Recovery of oculo-motor bias in neglect patients after prism adaptation , 2004, Neuropsychologia.

[73]  Francesca Meneghello,et al.  Mechanisms Underlying Visuo-Spatial Amelioration of Neglect After Prism Adaptation , 2004, Cortex.

[74]  M. Nitsche,et al.  Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence. , 2004, Investigative ophthalmology & visual science.

[75]  J. Rothwell,et al.  Level of action of cathodal DC polarisation induced inhibition of the human motor cortex , 2003, Clinical Neurophysiology.

[76]  E. Bisiach,et al.  1 Hz repetitive transcranial magnetic stimulation of the unaffected hemisphere ameliorates contralesional visuospatial neglect in humans , 2003, Neuroscience Letters.

[77]  S. Clarke,et al.  EFNS guidelines on cognitive rehabilitation: report of an EFNS task force , 2005, European journal of neurology.

[78]  Y. Rossetti,et al.  Ameliorating neglect with prism adaptation: visuo-manual and visuo-verbal measures , 2002, Neuropsychologia.

[79]  M. Nitsche,et al.  Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. , 2002, Brain : a journal of neurology.

[80]  F. Meneghello,et al.  Long-lasting amelioration of visuospatial neglect by prism adaptation. , 2002, Brain : a journal of neurology.

[81]  N. Tzourio-Mazoyer,et al.  Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain , 2002, NeuroImage.

[82]  M. Nitsche,et al.  Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans , 2001, Neurology.

[83]  E. Bisiach,et al.  rTMS of the unaffected hemisphere transiently reduces contralesional visuospatial hemineglect , 2001, Neurology.

[84]  E. Bisiach,et al.  Timing of right parietal and frontal cortex activity in visuo-spatial perception: a TMS study in normal individuals , 2001, Neuroreport.

[85]  Scott T. Grafton,et al.  Functional Anatomy of Nonvisual Feedback Loops during Reaching: A Positron Emission Tomography Study , 2001, The Journal of Neuroscience.

[86]  M. Nitsche,et al.  Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation , 2000, The Journal of physiology.

[87]  Filippo Brighina,et al.  Contralateral neglect induced by right posterior parietal rTMS in healthy subjects , 2000, Neuroreport.

[88]  P. Astikainen,et al.  Cortical and subcortical visual event‐related potentials to oddball stimuli in rabbits , 2000, Neuroreport.

[89]  H. Bekkering,et al.  Ocular gaze is anchored to the target of an ongoing pointing movement. , 2000, Journal of neurophysiology.

[90]  M. Perenin,et al.  Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect , 1998, Nature.

[91]  K. Thuomas,et al.  CT and MR evaluation of pericardial and retrosternal adhesions after cardiac surgery. , 1991, Journal of computer assisted tomography.

[92]  J. Marshall,et al.  VISUOSPATIAL NEGLECT: UNDERLYING FACTORS AND TEST SENSITIVITY , 1989, The Lancet.

[93]  B. Wilson,et al.  Development of a behavioral test of visuospatial neglect. , 1987, Archives of physical medicine and rehabilitation.

[94]  J. Sprague,et al.  Interaction of Cortex and Superior Colliculus in Mediation of Visually Guided Behavior in the Cat , 1966, Science.

[95]  G W Thickbroom,et al.  Transcranial direct current stimulation (tDCS) and robotic practice in chronic stroke: the dimension of timing. , 2013, NeuroRehabilitation.

[96]  H. C. Dijkerman,et al.  Acute neglect rehabilitation using repetitive prism adaptation: a randomized placebo-controlled trial. , 2008, Restorative neurology and neuroscience.

[97]  Sergio P. Rigonatti,et al.  Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients. , 2007, Restorative neurology and neuroscience.

[98]  K. Shindo,et al.  Long-term effect of low-frequency repetitive transcranial magnetic stimulation over the unaffected posterior parietal cortex in patients with unilateral spatial neglect. , 2006, Journal of rehabilitation medicine.

[99]  Walter Paulus,et al.  Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects. , 2003, Supplements to Clinical neurophysiology.

[100]  C. Rorden,et al.  Stereotaxic display of brain lesions. , 2000, Behavioural neurology.