An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype
暂无分享,去创建一个
Nicholas C. Flytzanis | C. Burge | A. Cheng | J. Condeelis | F. Gertler | M. Oktay | M. Balsamo | I. Shapiro
[1] Chonghui Cheng,et al. CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. , 2011, The Journal of clinical investigation.
[2] Stuart Thomson,et al. A systems view of epithelial–mesenchymal transition signaling states , 2010, Clinical & Experimental Metastasis.
[3] Yi Xing,et al. An ESRP‐regulated splicing programme is abrogated during the epithelial–mesenchymal transition , 2010, The EMBO journal.
[4] C. Ghigna,et al. Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene , 2010, The Journal of cell biology.
[5] Kakajan Komurov,et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes , 2010, Proceedings of the National Academy of Sciences.
[6] Lior Pachter,et al. Exon-Level Microarray Analyses Identify Alternative Splicing Programs in Breast Cancer , 2010, Molecular Cancer Research.
[7] A. Ladd,et al. Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity , 2010, RNA biology.
[8] Gene W. Yeo,et al. Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. , 2009, Molecular cell.
[9] Claude C. Warzecha,et al. The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events , 2009, RNA biology.
[10] Jeffrey M. Rosen,et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features , 2009, Proceedings of the National Academy of Sciences.
[11] Y. Kaneda,et al. Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. , 2009, Molecular biology of the cell.
[12] Walter Hunziker,et al. Vimentin regulates scribble activity by protecting it from proteasomal degradation. , 2009, Molecular biology of the cell.
[13] Sherif Abou Elela,et al. Cancer-associated regulation of alternative splicing , 2009, Nature Structural &Molecular Biology.
[14] R. Weinberg,et al. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits , 2009, Nature Reviews Cancer.
[15] Claude C. Warzecha,et al. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. , 2009, Molecular cell.
[16] John S. Condeelis,et al. Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination , 2009, Clinical Cancer Research.
[17] Gene W. Yeo,et al. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells , 2009, Nature Structural &Molecular Biology.
[18] J. Klijn,et al. Low-risk susceptibility alleles in 40 human breast cancer cell lines , 2009, BMC Cancer.
[19] Gerhard Christofori,et al. EMT, the cytoskeleton, and cancer cell invasion , 2009, Cancer and Metastasis Reviews.
[20] T. Meyer,et al. Modular control of endothelial sheet migration. , 2008, Genes & development.
[21] Sherif Abou Elela,et al. Identification of alternative splicing markers for breast cancer. , 2008, Cancer research.
[22] B. Olsen,et al. Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. , 2008, Molecular biology of the cell.
[23] Eric T. Wang,et al. Alternative Isoform Regulation in Human Tissue Transcriptomes , 2008, Nature.
[24] Tiffany W Guo,et al. Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. , 2008, Molecular biology of the cell.
[25] O. De Wever,et al. Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. , 2008, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[26] U. Philippar,et al. Human Mena+11a Isoform Serves as a Marker of Epithelial Phenotype and Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Pancreatic Cancer Cell Lines , 2008, Clinical Cancer Research.
[27] B. Williams,et al. Mapping and quantifying mammalian transcriptomes by RNA-Seq , 2008, Nature Methods.
[28] Robert A. Weinberg,et al. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. , 2008, Developmental cell.
[29] P. Febbo,et al. Dunning rat prostate adenocarcinomas and alternative splicing reporters: powerful tools to study epithelial plasticity in prostate tumors in vivo , 2008, Clinical & Experimental Metastasis.
[30] Wenjun Guo,et al. The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.
[31] M. Waltham,et al. Epithelial mesenchymal transition traits in human breast cancer cell lines , 2008, Clinical & Experimental Metastasis.
[32] Andrew J Ewald,et al. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. , 2008, Developmental cell.
[33] W. Nelson,et al. Regulation of cell-cell adhesion by the cadherin-catenin complex. , 2008, Biochemical Society transactions.
[34] R. Eils,et al. Systemic spread is an early step in breast cancer. , 2008, Cancer cell.
[35] J. Clements,et al. Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression , 2007, Journal of cellular physiology.
[36] Alan Wells,et al. EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation , 2007, Journal of Cell Science.
[37] H. Kajiyama,et al. Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. , 2007, International journal of oncology.
[38] Alicia Zhou,et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers , 2007, Proceedings of the National Academy of Sciences.
[39] M. Pajares,et al. Alternative splicing: an emerging topic in molecular and clinical oncology. , 2007, The Lancet. Oncology.
[40] G. Sherlock,et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. , 2007, The New England journal of medicine.
[41] Harikrishna Nakshatri,et al. CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis , 2006, Breast Cancer Research.
[42] A. Rajasekaran,et al. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. , 2006, Cancer research.
[43] J. Thierry-Mieg,et al. AceView: a comprehensive cDNA-supported gene and transcripts annotation , 2006, Genome Biology.
[44] L. Ellis,et al. Chronic Oxaliplatin Resistance Induces Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cell Lines , 2006, Clinical Cancer Research.
[45] B. Blencowe. Alternative Splicing: New Insights from Global Analyses , 2006, Cell.
[46] M. Swanson,et al. Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. , 2006, Human molecular genetics.
[47] A. Kornblihtt,et al. The connection between splicing and cancer , 2006, Journal of Cell Science.
[48] G. Christofori. New signals from the invasive front , 2006, Nature.
[49] John Condeelis,et al. Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis , 2006, Cell.
[50] Michael R Green,et al. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. , 2005, Molecular cell.
[51] B. Gumbiner,et al. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin , 2005, The Journal of cell biology.
[52] E. Hay,et al. Microarray analysis of gene expression during epithelial–mesenchymal transformation , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.
[53] D. Tarin,et al. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? , 2005, Cancer research.
[54] Keith Baggerly,et al. Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression , 2004, Breast Cancer Research.
[55] S. Ramaswamy,et al. Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.
[56] J. Gutkind,et al. Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential , 2004, Oncogene.
[57] Anne Vincent-Salomon,et al. Epithelial–mesenchymal transition in breast cancer development , 2003 .
[58] M. Fraga,et al. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors , 2003, Journal of Cell Science.
[59] R. Tibshirani,et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[60] Paul J. Williams,et al. A Bone‐Seeking Clone Exhibits Different Biological Properties from the MDA‐MB‐231 Parental Human Breast Cancer Cells and a Brain‐Seeking Clone In Vivo and In Vitro , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[61] W. Hahn,et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. , 2001, Genes & development.
[62] Myles Brown,et al. Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription , 2000, Cell.
[63] M. Troxell,et al. Inhibiting cadherin function by dominant mutant E-cadherin expression increases the extent of tight junction assembly. , 2000, Journal of cell science.
[64] K. Pienta,et al. Rapid ("warm") autopsy study for procurement of metastatic prostate cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[65] S. Hellman,et al. Clinical progression of breast cancer malignant behavior: what to expect and when to expect it. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[66] F. van Roy,et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. , 1998, Genomics.
[67] J. Claverie,et al. The significance of digital gene expression profiles. , 1997, Genome research.
[68] M. Balda,et al. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical- basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein , 1996, The Journal of cell biology.
[69] H. Peterse,et al. Immunomagnetic purification of human breast carcinoma cells allows tumor-specific detection of multidrug resistance gene 1-mRNA by reverse transcriptase polymerase chain reaction in fine-needle aspirates. , 1995, Laboratory investigation; a journal of technical methods and pathology.
[70] J. Thiery,et al. Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. , 1994, Molecular biology of the cell.
[71] B. Thisse,et al. The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern. , 1987, Nucleic acids research.