A liposome-based nanostructure for aptamer directed delivery.

A therapeutic aptamer conjugated liposome drug delivery system which delivered loaded drug to target cells with high specificity and excellent efficiency was prepared and characterized.

[1]  H. Shmeeda,et al.  Pros and Cons of the Liposome Platform in Cancer Drug Targeting , 2006, Journal of liposome research.

[2]  A. Hauschild,et al.  Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T‐cell lymphoma , 2003, Cancer.

[3]  Robert Langer,et al.  Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles , 2008, Proceedings of the National Academy of Sciences.

[4]  V. Torchilin,et al.  TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Vladimir P Torchilin,et al.  Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[6]  R. Schiffelers,et al.  Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[7]  G. Hardee,et al.  Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo. , 2003, Bioconjugate chemistry.

[8]  D. Shangguan,et al.  Aptamers evolved from live cells as effective molecular probes for cancer study , 2006, Proceedings of the National Academy of Sciences.

[9]  S. Nguyen,et al.  Polymer-caged lipsomes: a pH-responsive delivery system with high stability. , 2007, Journal of the American Chemical Society.

[10]  Sérgio Simões,et al.  On the formulation of pH-sensitive liposomes with long circulation times. , 2004, Advanced drug delivery reviews.

[11]  Christopher Scarfone,et al.  Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. , 2003, Cancer cell.

[12]  Theresa M Allen,et al.  Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. , 2002, Cancer research.

[13]  D. Papahadjopoulos,et al.  Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. , 1999, Pharmacological reviews.

[14]  S. Boxer,et al.  General method for modification of liposomes for encoded assembly on supported bilayers. , 2005, Journal of the American Chemical Society.

[15]  Weihong Tan,et al.  Cell-specific internalization study of an aptamer from whole cell selection. , 2008, Chemistry.

[16]  P. Low,et al.  Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors , 2002, Cancer Immunology, Immunotherapy.

[17]  Weihong Tan,et al.  Cell-specific aptamer probes for membrane protein elucidation in cancer cells. , 2008, Journal of proteome research.

[18]  V. Torchilin Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[19]  A. Baeumner,et al.  Synthesis of a liposome incorporated 1-carboxyalkylxanthine-phospholipid conjugate and its recognition by an RNA aptamer. , 2007, Talanta.

[20]  S. Shuto,et al.  Anti‐neovascular therapy by liposomal DPP‐CNDAC targeted to angiogenic vessels , 2002, FEBS letters.

[21]  I. Rubinstein,et al.  VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[22]  W. Jiskoot,et al.  Functional Characterization of an Endosome-disruptive Peptide and Its Application in Cytosolic Delivery of Immunoliposome-entrapped Proteins* , 2002, The Journal of Biological Chemistry.

[23]  J. M. Healy,et al.  Complex target SELEX. , 2008, Accounts of chemical research.

[24]  M. Gnant,et al.  Pilot study with pegylated liposomal doxorubicin for advanced or unresectable hepatocellular carcinoma , 2001, British Journal of Cancer.

[25]  Robert Langer,et al.  Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers , 2008, Proceedings of the National Academy of Sciences.

[26]  G. Fields,et al.  Targeted drug delivery utilizing protein-like molecular architecture. , 2007, Journal of the American Chemical Society.

[27]  J. Richie,et al.  Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.