Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

[1]  F. Tacke,et al.  Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities , 2020, Cellular & Molecular Immunology.

[2]  Hongbing Shen,et al.  M2 Macrophage–Derived Exosomes Facilitate HCC Metastasis by Transferring αMβ2 Integrin to Tumor Cells , 2020, Hepatology.

[3]  F. Tacke,et al.  Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis , 2020, Expert opinion on pharmacotherapy.

[4]  E. Wherry,et al.  Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes , 2020, The Journal of Immunology.

[5]  F. Tacke,et al.  The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis , 2020, Seminars in Liver Disease.

[6]  N. Henderson,et al.  Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis , 2020, Nature Reviews Gastroenterology & Hepatology.

[7]  S. Colgan,et al.  Hypoxia‐Inducible Factor‐2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin‐6 , 2020, Hepatology.

[8]  F. Ginhoux,et al.  Deciphering human macrophage development at single-cell resolution , 2020, Nature.

[9]  W. Jeong,et al.  Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease , 2020, Experimental & Molecular Medicine.

[10]  F. Tacke,et al.  Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages. , 2020, Journal of hepatology.

[11]  C. Glass,et al.  Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. , 2020, Immunity.

[12]  Lei Liu,et al.  Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human , 2020, Cell Discovery.

[13]  J. Wan,et al.  LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling , 2020, Science Translational Medicine.

[14]  Beicheng Sun,et al.  PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis , 2020, Theranostics.

[15]  T. Luedde,et al.  The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis , 2020, Journal of clinical medicine.

[16]  Hailong Wu,et al.  Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury , 2020, Cell Death & Disease.

[17]  F. Hildebrand,et al.  Intestinal Microbiome‐Macrophage Crosstalk Contributes to Cholestatic Liver Disease by Promoting Intestinal Permeability in Mice , 2020, Hepatology.

[18]  E. O'Duibhir,et al.  Alternatively activated macrophages promote resolution of necrosis following acute liver injury , 2020, Journal of hepatology.

[19]  V. Wong,et al.  Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials. , 2020, Journal of hepatology.

[20]  J. M. Lanao,et al.  Targeting of Hepatic Macrophages by Therapeutic Nanoparticles , 2020, Frontiers in Immunology.

[21]  P. Lampertico,et al.  Epidemiology and surveillance for hepatocellular carcinoma: New trends. , 2020, Journal of hepatology.

[22]  B. A. David,et al.  Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets , 2020, The Journal of experimental medicine.

[23]  V. Wong,et al.  Cenicriviroc Treatment for Adults With Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study , 2020, Hepatology.

[24]  P. Klivényi,et al.  Selecting dopamine depleters for hyperkinetic movement disorders: how do we choose? , 2020, Expert opinion on pharmacotherapy.

[25]  F. Tacke,et al.  The Unexpected Role of Neutrophils for Resolving Liver Inflammation by Transmitting MicroRNA‐223 to Macrophages , 2019, Hepatology.

[26]  J. Boyer,et al.  Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse , 2019, Cellular and molecular gastroenterology and hepatology.

[27]  T. Vanhaecke,et al.  Anti-NASH Drug Development Hitches a Lift on PPAR Agonism , 2019, Cells.

[28]  Je-Hyun Yoon,et al.  Mitochondrial Double‐Stranded RNA in Exosome Promotes Interleukin‐17 Production Through Toll‐Like Receptor 3 in Alcohol‐associated Liver Injury , 2019, Hepatology.

[29]  R. Schwabe,et al.  Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. , 2019, Cell metabolism.

[30]  H. Conjeevaram,et al.  Effects of Belapectin, an Inhibitor of Galectin-3, in Patients with Nonalcoholic Steatohepatitis With Cirrhosis And Portal Hypertension. , 2019, Gastroenterology.

[31]  R. Weiskirchen,et al.  Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases , 2019, Front. Immunol..

[32]  Y. Saeys,et al.  Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche , 2019, Immunity.

[33]  C. Glass,et al.  Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. , 2019, Immunity.

[34]  J. Fallowfield,et al.  Safety profile of autologous macrophage therapy for liver cirrhosis , 2019, Nature Medicine.

[35]  C. Ponting,et al.  Resolving the fibrotic niche of human liver cirrhosis at single cell level , 2019, Nature.

[36]  H. Van Vlierberghe,et al.  Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers. , 2019, Journal of hepatology.

[37]  Xuehao Wang,et al.  Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities , 2019, Molecular Cancer.

[38]  Jiandie D. Lin,et al.  Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. , 2019, Molecular cell.

[39]  I. Amit,et al.  Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner , 2019, Cell.

[40]  S. Forbes,et al.  Macrophages as a Cell-Based Therapy for Liver Disease , 2019, Seminars in Liver Disease.

[41]  Jun Yu,et al.  Bone marrow‐derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells , 2019, The Journal of pathology.

[42]  F. Tacke,et al.  Liver Macrophages: Old Dogmas and New Insights , 2019, Hepatology communications.

[43]  Haiyang Xie,et al.  Blocking Triggering Receptor Expressed on Myeloid Cells‐1‐Positive Tumor‐Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti‐Programmed Cell Death Ligand 1 Resistance in Liver Cancer , 2019, Hepatology.

[44]  Caroline L. Wilson,et al.  Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer , 2019, Nature Medicine.

[45]  S. Rajagopalan,et al.  MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance , 2019, International Journal of Obesity.

[46]  F. He,et al.  Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair , 2019, Nature Communications.

[47]  Yeonhee Cho,et al.  Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol‐Induced Liver Damage, Steatosis, and Inflammation in Mice , 2019, Hepatology.

[48]  M. Gale,et al.  Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation , 2019, PLoS pathogens.

[49]  Yongsheng Yu,et al.  STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis , 2018, The Journal of clinical investigation.

[50]  M. Mcphail,et al.  The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure , 2018, Front. Immunol..

[51]  H. Katagiri,et al.  Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation , 2018, Nature Communications.

[52]  T. Weichhart,et al.  Iron Regulation: Macrophages in Control , 2018, Pharmaceuticals.

[53]  Zong-fang Li,et al.  The Spleen Promotes the Secretion of CCL2 and Supports an M1 Dominant Phenotype in Hepatic Macrophages During Liver Fibrosis , 2018, Cellular Physiology and Biochemistry.

[54]  S. Weinman,et al.  Regulation of Hepatic Inflammation via Macrophage Cell Death , 2018, Seminars in Liver Disease.

[55]  Gary D Bader,et al.  Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations , 2018, Nature Communications.

[56]  X. Ruan,et al.  Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release. , 2018, Cellular immunology.

[57]  P. Kubes,et al.  α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis. , 2018, Cell host & microbe.

[58]  M. Guilliams,et al.  The role of Kupffer cells in hepatic iron and lipid metabolism. , 2018, Journal of hepatology.

[59]  G. Wynne,et al.  Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages , 2018, Front. Immunol..

[60]  Jie Zhang,et al.  Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution , 2018, International journal of biological sciences.

[61]  K. Kodys,et al.  Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90 , 2018, Hepatology.

[62]  T. Luedde,et al.  Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis , 2018, Hepatology.

[63]  R. Chung,et al.  Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet‐induced mouse model of nonalcoholic steatohepatitis , 2018, Hepatology communications.

[64]  S. Weinman,et al.  FOXO3-dependent apoptosis limits alcohol-induced liver inflammation by promoting infiltrating macrophage differentiation , 2018, Cell Death Discovery.

[65]  E. O'Duibhir,et al.  The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury , 2018, The Journal of Immunology.

[66]  P. Kubes,et al.  Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system , 2018, Nature Reviews Gastroenterology & Hepatology.

[67]  V. Wong,et al.  A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis , 2018, Hepatology.

[68]  Z. Goodman,et al.  The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial , 2017, Hepatology.

[69]  M. Köster,et al.  Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis. , 2017, Journal of hepatology.

[70]  F. Tacke,et al.  Dynamic plasticity of macrophage functions in diseased liver. , 2017, Cellular immunology.

[71]  D. Mastroeni,et al.  Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms , 2017, Alzheimer's & Dementia.

[72]  A. Geerts,et al.  Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool. , 2017, Cellular immunology.

[73]  Masato Tanaka,et al.  CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. , 2017, JCI insight.

[74]  D. Stolz,et al.  MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock , 2017, PLoS pathogens.

[75]  R. Ray,et al.  Hepatitis C virus–induced CCL5 secretion from macrophages activates hepatic stellate cells , 2017, Hepatology.

[76]  William Ritchie,et al.  A Liver Capsular Network of Monocyte‐Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment , 2017, Immunity.

[77]  Liangguo Xu,et al.  Role of gp91phox in hepatic macrophage programming and alcoholic liver disease , 2017, Hepatology communications.

[78]  F. Hamel,et al.  Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis , 2017, World journal of gastroenterology.

[79]  Y. Kong,et al.  Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells , 2017, Science.

[80]  F. Tacke.  Targeting hepatic macrophages to treat liver diseases. , 2017, Journal of hepatology.

[81]  Eyal David,et al.  Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury , 2017, Front. Immunol..

[82]  Y. Iwakura,et al.  Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity , 2017, Cellular & Molecular Immunology.

[83]  K. Ikejima,et al.  Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice. , 2017, Laboratory investigation; a journal of technical methods and pathology.

[84]  Haoming Zhou,et al.  Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury , 2017, The Journal of Immunology.

[85]  K. Schroder,et al.  NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. , 2017, Journal of hepatology.

[86]  C. Weston,et al.  MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure , 2017, Gut.

[87]  K. Moore,et al.  Vitamin A mediates conversion of monocyte-derived macrophages into tissue resident macrophages during alternative activation , 2017, Nature Immunology.

[88]  Z. Tian,et al.  HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. , 2017, Journal of hepatology.

[89]  H. Jaeschke,et al.  Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure. , 2017, Journal of hepatology.

[90]  F. Tacke,et al.  Liver macrophages in tissue homeostasis and disease , 2017, Nature Reviews Immunology.

[91]  R. Kleemann,et al.  The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis , 2017, PloS one.

[92]  Yingwei Chen,et al.  Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis , 2016, Oncotarget.

[93]  B. A. David,et al.  Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. , 2016, Gastroenterology.

[94]  T. Luedde,et al.  Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury , 2016, Hepatology.

[95]  Hyung-Sik Kang,et al.  Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice , 2016, Autophagy.

[96]  D. Xia,et al.  Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. , 2016, Immunity.

[97]  X. Wang,et al.  Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. , 2016, Cancer cell.

[98]  Jane E. Dalton,et al.  Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions , 2016, Journal of hepatology.

[99]  G. Cortopassi,et al.  Galectin‐3 regulates inflammasome activation in cholestatic liver injury , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[100]  Christoph Bock,et al.  Specification of tissue-resident macrophages during organogenesis , 2016, Science.

[101]  K. Mitchell,et al.  Monocyte chemoattractant protein-1 is not required for liver regeneration after partial hepatectomy , 2016, Journal of Inflammation.

[102]  F. Rosenbauer,et al.  Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation , 2016, The EMBO journal.

[103]  M. Blay,et al.  Dietary fatty acid composition is sensed by the NLRP3 inflammasome: omega-3 fatty acid (DHA) prevents NLRP3 activation in human macrophages. , 2016, Food & function.

[104]  P. Kubes,et al.  CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria. , 2016, Cell host & microbe.

[105]  T. Schulz,et al.  Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens , 2016, The Journal of Immunology.

[106]  R. Weissleder,et al.  On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver , 2016, Nature Medicine.

[107]  Stefan Rose-John,et al.  IL-6 pathway in the liver: From physiopathology to therapy. , 2016, Journal of hepatology.

[108]  F. Tacke,et al.  Liver Fibrosis: From Pathogenesis to Novel Therapies , 2016, Digestive Diseases.

[109]  Xiuping Liu,et al.  A new HIF‐1α/RANTES‐driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice , 2016, Hepatology.

[110]  P. Kubes,et al.  A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair , 2016, Cell.

[111]  D. Adams,et al.  Platelets: No longer bystanders in liver disease , 2016, Hepatology.

[112]  She Chen,et al.  CD86+/CD206+, Diametrically Polarized Tumor-Associated Macrophages, Predict Hepatocellular Carcinoma Patient Prognosis , 2016, International journal of molecular sciences.

[113]  R. Coffman,et al.  Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. , 2016, The Journal of clinical investigation.

[114]  F. Tacke,et al.  Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies , 2016, Cellular and Molecular Immunology.

[115]  N. Hacohen,et al.  Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells , 2016, Science.

[116]  Frank Tacke,et al.  Immunology in the liver — from homeostasis to disease , 2016, Nature Reviews Gastroenterology &Hepatology.

[117]  Y. Saeys,et al.  Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells , 2016, Nature Communications.

[118]  Ji Luo,et al.  NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis , 2016, Nature.

[119]  Jingyuan Fu,et al.  Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells , 2015, Hepatology.

[120]  I. Henderson,et al.  Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. , 2015, The Journal of clinical investigation.

[121]  D. Hume,et al.  CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure , 2015, Gastroenterology.

[122]  K. Kodys,et al.  MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages* , 2015, The Journal of Biological Chemistry.

[123]  F. Tacke,et al.  CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis , 2015, Hepatology.

[124]  Ruth Ganss,et al.  Kupffer cell–monocyte communication is essential for initiating murine liver progenitor cell–mediated liver regeneration , 2015, Hepatology.

[125]  M. Nakashima,et al.  Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy , 2015, PloS one.

[126]  A. Grakoui,et al.  The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice , 2015, Hepatology.

[127]  Yuzhang Wu,et al.  The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis , 2015, PLoS pathogens.

[128]  Hailong Wu,et al.  Defective Initiation of Liver Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6/Stat3 Pathway , 2015, International journal of biological sciences.

[129]  K. Deisseroth,et al.  Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer , 2015, Cell.

[130]  T. Billiar,et al.  Damage‐associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury , 2015, Hepatology.

[131]  G. Szabo,et al.  Inflammasome activation and function in liver disease , 2015, Nature Reviews Gastroenterology &Hepatology.

[132]  F. Ginhoux,et al.  Liver inflammation abrogates immunological tolerance induced by Kupffer cells , 2015, Hepatology.

[133]  E. Edelman,et al.  Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse. , 2015, Journal of hepatology.

[134]  F. Ginhoux,et al.  C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. , 2015, Immunity.

[135]  R. Ransohoff,et al.  A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury , 2015, The Journal of experimental medicine.

[136]  H. Tsukamoto,et al.  NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. , 2015, The Journal of clinical investigation.

[137]  D. Brenner,et al.  Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[138]  Gérard Eberl,et al.  Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection. , 2015, Immunity.

[139]  S. Kim,et al.  Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion , 2015, The FEBS journal.

[140]  F. Geissmann,et al.  Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors , 2014, Nature.

[141]  X. Chen,et al.  The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL‐18 production in an inflammasome‐dependent and ‐independent manner , 2014, European journal of immunology.

[142]  F. Tacke,et al.  Therapeutic targeting of liver inflammation and fibrosis by nanomedicine. , 2014, Hepatobiliary surgery and nutrition.

[143]  Bin Gao,et al.  Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice , 2014, Journal of leukocyte biology.

[144]  F. Tacke,et al.  Roles for chemokines in liver disease. , 2014, Gastroenterology.

[145]  S. Owumi,et al.  Depletion of Kupffer cells modulates ethanol‐induced hepatocyte DNA synthesis in C57Bl/6 mice , 2014, Environmental toxicology.

[146]  B. Everts,et al.  Ly6Chi Monocyte Recruitment Is Responsible for Th2 Associated Host-Protective Macrophage Accumulation in Liver Inflammation due to Schistosomiasis , 2014, PLoS pathogens.

[147]  Maxim N. Artyomov,et al.  Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival , 2014, The Journal of experimental medicine.

[148]  J. Aguilera-Lizarraga,et al.  Maraviroc, a CCR5 antagonist, ameliorates the development of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD). , 2014, The Journal of antimicrobial chemotherapy.

[149]  Z. Halpern,et al.  Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury , 2014, The Journal of Immunology.

[150]  P. Loke,et al.  Ly6Chigh Monocytes Become Alternatively Activated Macrophages in Schistosome Granulomas with Help from CD4+ Cells , 2014, PLoS pathogens.

[151]  J. Wan,et al.  M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease. , 2014, The American journal of pathology.

[152]  Frank Tacke,et al.  Macrophage heterogeneity in liver injury and fibrosis. , 2014, Journal of hepatology.

[153]  Zheng Zhang,et al.  The role of neutrophils in the development of liver diseases , 2014, Cellular and Molecular Immunology.

[154]  T. Luedde,et al.  Pharmacological inhibition of the chemokine C‐C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly‐6C+ macrophage infiltration in mice , 2014, Hepatology.

[155]  T. Luedde,et al.  CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis , 2014, Gut.

[156]  N. Ohkohchi,et al.  Interaction of kupffer cells and platelets determines the severity of ischemia-reperfusion injury in steatosis. , 2014, The Tohoku journal of experimental medicine.

[157]  M. Sieweke,et al.  Beyond Stem Cells: Self-Renewal of Differentiated Macrophages , 2013, Science.

[158]  R. Schwabe,et al.  Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice , 2013, Hepatology.

[159]  Shizuo Akira,et al.  Autophagy in infection, inflammation and immunity , 2013, Nature Reviews Immunology.

[160]  Cheng-Jun Hu,et al.  Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. , 2013, Biochemical pharmacology.

[161]  C. Esmon,et al.  Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury , 2013, The Journal of Immunology.

[162]  T. Hibi,et al.  C‐C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice , 2013, Hepatology.

[163]  G. Cheng,et al.  ASC/caspase‐1/IL‐1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury , 2013, Hepatology.

[164]  P. Kubes,et al.  Nucleation of platelets with bloodborne pathogens on Kupffer cell precedes other innate immunity and contributes to bacterial clearance , 2013, Nature Immunology.

[165]  M. Netea,et al.  CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver , 2013, PloS one.

[166]  T. Luedde,et al.  Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis , 2013, The Journal of Immunology.

[167]  S. Forbes,et al.  Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling , 2013, Proceedings of the National Academy of Sciences.

[168]  C. Hagedorn,et al.  IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease , 2013, PLoS pathogens.

[169]  Liang Zheng,et al.  Succinate is an inflammatory signal that induces IL-1β through HIF-1α , 2013, Nature.

[170]  A. Mildner,et al.  Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. , 2013, Immunity.

[171]  S. Curbishley,et al.  Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics , 2013, Hepatology.

[172]  S. Friedman,et al.  CD11b+ Gr1+ bone marrow cells ameliorate liver fibrosis by producing interleukin‐10 in mice , 2012, Hepatology.

[173]  N. Ohkohchi,et al.  Interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury--an in vivo study. , 2012, The Journal of surgical research.

[174]  X. Lu,et al.  Tim‐3/galectin‐9 signaling pathway mediates T‐cell dysfunction and predicts poor prognosis in patients with hepatitis B virus‐associated hepatocellular carcinoma , 2012, Hepatology.

[175]  K. Kodys,et al.  IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. , 2012, The Journal of clinical investigation.

[176]  G. Szabo,et al.  Inflammasomes in liver diseases. , 2012, Journal of hepatology.

[177]  Jean S. Campbell,et al.  Liver regeneration. , 2012, Journal of hepatology.

[178]  N. Van Rooijen,et al.  Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[179]  S. Robson,et al.  P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[180]  K. Cianflone,et al.  Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat , 2012, PloS one.

[181]  T. Roskams,et al.  Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease , 2012, Nature Medicine.

[182]  T. Luedde,et al.  Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C‐C motif chemokine receptor 8 in mice , 2012, Hepatology.

[183]  T. Hibi,et al.  CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis. , 2012, Gastroenterology.

[184]  T. Roskams,et al.  Macrophage derived Wnt signalling opposes Notch signalling in a Numb mediated manner to specify HPC fate in chronic liver disease in human and mouse , 2012, Nature medicine.

[185]  T. Luedde,et al.  Senescence surveillance of pre-malignant hepatocytes limits liver cancer development , 2011, Nature.

[186]  N. Lanthier,et al.  Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury. , 2011, The American journal of pathology.

[187]  T. Luedde,et al.  Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury , 2011, Gut.

[188]  D. Brenner,et al.  Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. , 2011, Alcoholism, clinical and experimental research.

[189]  S. Menini,et al.  Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver. , 2011, Journal of hepatology.

[190]  Denis Gris,et al.  Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling , 2011, Nature Immunology.

[191]  Wei Wei,et al.  Enhanced liver regeneration in IL-10-deficient mice after partial hepatectomy via stimulating inflammatory response and activating hepatocyte STAT3. , 2011, The American journal of pathology.

[192]  E. Ravussin,et al.  The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance , 2010, Nature Medicine.

[193]  A. Aderem,et al.  Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria , 2010, Nature Immunology.

[194]  P. Kubes,et al.  Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation , 2010, Science.

[195]  T. Kalin,et al.  Forkhead Box M1 Transcription Factor Is Required for Macrophage Recruitment during Liver Repair , 2010, Molecular and Cellular Biology.

[196]  D. Brenner,et al.  Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. , 2010, Gastroenterology.

[197]  O. Soehnlein,et al.  Phagocyte partnership during the onset and resolution of inflammation , 2010, Nature Reviews Immunology.

[198]  R. Schnellmann,et al.  Murine Kupffer Cells Are Protective in Total Hepatic Ischemia/Reperfusion Injury with Bowel Congestion through IL-10 , 2010, The Journal of Immunology.

[199]  Maolin Yan,et al.  Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2,3-dioxygenase. , 2010, World journal of gastroenterology.

[200]  Hiroyasu Ito,et al.  Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice , 2010, Hepatology.

[201]  Lieping Chen,et al.  Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. , 2009, Cancer research.

[202]  I. Leclercq,et al.  Kupffer cells mediate leptin-induced liver fibrosis. , 2009, Gastroenterology.

[203]  P. Libby,et al.  Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites , 2009, Science.

[204]  R. Schwabe,et al.  CCR2 promotes hepatic fibrosis in mice , 2009, Hepatology.

[205]  R. Schwabe,et al.  CCR1 and CCR5 promote hepatic fibrosis in mice. , 2009, The Journal of clinical investigation.

[206]  F. Ginhoux,et al.  Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis , 2009, Hepatology.

[207]  J. Xu,et al.  High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. , 2009, Human pathology.

[208]  R. Kedl,et al.  Mechanism of T cell tolerance induction by murine hepatic Kupffer cells , 2008, Hepatology.

[209]  Yosuke Osawa,et al.  TLR4 enhances TGF-β signaling and hepatic fibrosis , 2007, Nature Medicine.

[210]  P. Adegboyega,et al.  Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. , 2007, Journal of hepatology.

[211]  M. Menger,et al.  Loss of NF-κB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy , 2007 .

[212]  J. Fallowfield,et al.  Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis1 , 2007, The Journal of Immunology.

[213]  N. Nieto.  Oxidative‐stress and IL‐6 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells , 2006, Hepatology.

[214]  F. Sutterwala,et al.  The Inflammasome: First Line of the Immune Response to Cell Stress , 2006, Cell.

[215]  J. Iredale,et al.  Galectin-3 regulates myofibroblast activation and hepatic fibrosis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[216]  L. Diehl,et al.  CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens , 2006, Cell.

[217]  N. Fausto,et al.  Liver regeneration , 2006, Hepatology.

[218]  Ana Cumano,et al.  A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells , 2006, Science.

[219]  R. Hayward.  Stress , 2005, The Lancet.

[220]  T. V. van Berkel,et al.  Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors. , 2005, Blood.

[221]  S. Forbes,et al.  Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. , 2005, The Journal of clinical investigation.

[222]  N. Van Rooijen,et al.  ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. , 2003, Gastroenterology.

[223]  J. Brady,et al.  Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. , 2002, Chemical research in toxicology.

[224]  D. Laskin,et al.  Role of CCR2 in macrophage migration into the liver during acetaminophen‐induced hepatotoxicity in the mouse , 2002, Hepatology.

[225]  K. Olthoff,et al.  Interleukin‐6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration , 2002, Hepatology.

[226]  S. Moestrup,et al.  Identification of the haemoglobin scavenger receptor , 2001, Nature.

[227]  T. V. van Berkel,et al.  Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice. , 2000, Blood.

[228]  H. Schouten,et al.  Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. , 2000, Liver.

[229]  K. Hatakeyama,et al.  The role of Kupffer cells in liver regeneration. , 1999, Archives of histology and cytology.

[230]  N. Kawada,et al.  In Vitro Migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation , 1999, Hepatology.

[231]  J. Peschon,et al.  Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[232]  E. Furth,et al.  Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice , 1996, Science.

[233]  P. van Eyken,et al.  Transferrin receptor expression in rat liver: Immunohistochemical and biochemical analysis of the effect of age and iron storage , 1990, Hepatology.

[234]  S. Friedman,et al.  Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. , 1989, The Journal of clinical investigation.

[235]  A. Tall,et al.  Cholesterol, inflammation and innate immunity , 2015, Nature Reviews Immunology.

[236]  F. Tacke,et al.  Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles. , 2017, Biomaterials.

[237]  M. Haneklaus,et al.  Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha , 2017 .

[238]  M. Czaja,et al.  Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β. , 2016, Journal of hepatology.

[239]  Kyunghee Choi,et al.  Homegrown Macrophages. , 2016, Immunity.

[240]  T. Luedde,et al.  Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases. , 2015, Biomaterials.

[241]  M. Menger,et al.  Loss of NF-kappaB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[242]  H. Wacker,et al.  Kinetics of Kupffer cells as shown by parabiosis and combined autoradiographic/immunohistochemical analysis , 1986, Virchows Archiv. B, Cell pathology including molecular pathology.

[243]  J. Fallowfield,et al.  Edinburgh Research Explorer Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis Differential Ly-6C expression identi fi es the recruited macrophage phenotype, which orchestrates the regression of murine liver fi brosis , 2022 .