Solid-Phase Synthesis of 5′-Deoxy-5′-Amino-Clitocine Analogues

Several 6-substituted-amino-5′-deoxy-5′-amino-clitocine analogues were synthesized in a parallel fashion in solid phase. The desired scaffold was generated by coupling 2,3-O-bis-(t-butyl- dimethylsilyl)-5-N-(monomethoxytrityl-polystyrene-resin)-1,5-diamino-5-deoxy-β-D-ribofuranose and 4,6-dichloro-5-nitropyrimidine. The scaffold was then reacted with a variety of amines to generate a small library of 14 analogues of 5′-deoxy-5′-amino-clitocine following a protocol developed earlier.

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