Infrequency of colonization with Oxalobacter formigenes in inflammatory bowel disease: Possible role in renal stone formation

Background and Aim:  Calcium oxalate renal stones (RS) and hyperoxaluria are common in patients with inflammatory bowel disease (IBD). The absence of intestinal oxalate degrading bacteria, Oxalobacter formigenes, may cause hyperoxaluria in IBD. The aim of the present study was to examine: (i) the colonization of O. formigenes in patients with IBD and controls and to correlate its presence with urinary oxalate excretion; and (ii) urinary analytes contributing to RS in IBD.

[1]  G. Rajagopal A simple colorimetric procedure for estimation of citric acid in urine. , 1984, Indian journal of experimental biology.

[2]  E. Hylander,et al.  Urolithiasis and hyperoxaluria in chronic inflammatory bowel disease. , 1979, Scandinavian journal of gastroenterology.

[3]  M. Liebman,et al.  Microbial oxalate degradation: Effects on oxalate and calcium balance in humans , 1989 .

[4]  J. Doré,et al.  Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon , 2003, Gut.

[5]  Banner Mp Genitourinary complications of inflammatory bowel disease. , 1987 .

[6]  M. Neurath,et al.  T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans , 1999, Gut.

[7]  W. Grzeszczak,et al.  [Pathogenesis and treatment of kidney stones]. , 1994, Wiadomosci lekarskie.

[8]  Z. Akcetin,et al.  Urinary factors of kidney stone formation in patients with Crohn's disease , 1988, Klinische Wochenschrift.

[9]  M. Stelzner,et al.  Nephrolithiasis and urine ion changes in ulcerative colitis patients undergoing colectomy and endorectal ileal pullthrough. , 1990, The Journal of surgical research.

[10]  C. Schultsz,et al.  The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls. , 1999, Gastroenterology.

[11]  C. Pai,et al.  Is Crohn's disease rare in India? , 2000, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.

[12]  I. Bosaeus,et al.  Cholelithiasis and urolithiasis in Crohn's disease. , 1987, Scandinavian journal of gastroenterology.

[13]  R. Gillberg,et al.  URINARY OXALATE ON A HIGH-OXALATE DIET AS A CLINICAL TEST OF MALABSORPTION , 1977, The Lancet.

[14]  H. Sidhu,et al.  Identification and classification of Oxalobacter formigenes strains by using oligonucleotide probes and primers , 1997, Journal of clinical microbiology.

[15]  S. Campbell,et al.  Risk factors for developing renal stones in inflammatory bowel disease , 2002, BJU international.

[16]  R. D. Mittal,et al.  Role of Oxalobacter formigenes in calcium oxalate stone disease: a study from North India. , 2002, European urology.

[17]  W. Mayberry,et al.  Oxalobacter formigenes gen. nov., sp. nov.: oxalate-degrading anaerobes that inhabit the gastrointestinal tract , 1985, Archives of Microbiology.

[18]  M. Miglioli,et al.  Renal stone formation in patients with inflammatory bowel disease. , 1993, Scanning microscopy.

[19]  G. Hill,et al.  Effect of intestinal surgery on the risk of urinary stone formation. , 1981, Gut.

[20]  C. Samuell A study of glycosaminoglycan excretion in normal and stone-forming subjects using a modified cetylpyridinium chloride technique. , 1981, Clinica chimica acta; international journal of clinical chemistry.

[21]  J. Weiss,et al.  Multiplex PCR assay and simple preparation method for stool specimens detect enterotoxigenic Escherichia coli DNA during course of infection , 1995, Journal of clinical microbiology.

[22]  M. Banner Genitourinary complications of inflammatory bowel disease. , 1987, Radiologic clinics of North America.