Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF)

[1]  J. Kirkland,et al.  Cellular senescence and senolytics: the path to the clinic , 2022, Nature Medicine.

[2]  Tinghong Ye,et al.  Targeting fibrosis: mechanisms and clinical trials , 2022, Signal Transduction and Targeted Therapy.

[3]  S. Tabibzadeh Repair, regeneration and rejuvenation require un-entangling pluripotency from senescence , 2022, Ageing Research Reviews.

[4]  G. F. Calvo,et al.  Behavioural immune landscapes of inflammation , 2022, Nature.

[5]  Hong Wang,et al.  Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis , 2021, Cell Death Discovery.

[6]  N. Musi,et al.  Cellular Senescence in Idiopathic Pulmonary Fibrosis , 2021, Current Molecular Biology Reports.

[7]  M. Collado,et al.  The role of cellular senescence in tissue repair and regeneration , 2021, Mechanisms of Ageing and Development.

[8]  Hong Wang,et al.  Radiation-Induced Senescence in p16+/LUC Mouse Lung Compared to Bone Marrow Multilineage Hematopoietic Progenitor Cells , 2021, Radiation Research.

[9]  F. Fan,et al.  Potential role of senescent macrophages in radiation-induced pulmonary fibrosis , 2021, Cell Death & Disease.

[10]  C. Yao,et al.  Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis , 2021, International journal of molecular sciences.

[11]  Yvette N. Lamb Nintedanib: A Review in Fibrotic Interstitial Lung Diseases , 2021, Drugs.

[12]  Shi-Ming Chen,et al.  The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT , 2021, PloS one.

[13]  Kun Sun,et al.  Silica dust exposure induces pulmonary fibrosis through autophagy signaling , 2021, Environmental toxicology.

[14]  M. Kasper,et al.  Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis , 2021, Frontiers in Medicine.

[15]  M. Laakso,et al.  Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity , 2020, Nature metabolism.

[16]  D. Sheppard,et al.  Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung , 2020, bioRxiv.

[17]  W. Merkt,et al.  Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis. , 2019, Seminars in cell & developmental biology.

[18]  Y. Kluger,et al.  Single-cell connectomic analysis of adult mammalian lungs , 2019, Science Advances.

[19]  S. D’Costa,et al.  Controlled induction and targeted elimination of p16INK4a‐expressing chondrocytes in cartilage explant culture , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  P. Okunieff,et al.  Cellular senescence and radiation-induced pulmonary fibrosis. , 2019, Translational research : the journal of laboratory and clinical medicine.

[21]  A. Shilatifard,et al.  Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis , 2019, American journal of respiratory and critical care medicine.

[22]  J. Rubin,et al.  Adipose‐Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor‐Mediated Transforming Growth Factor‐β Downregulation and Recruitment of Bone Marrow Cells , 2019, Stem cells.

[23]  P. Wipf,et al.  Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca-/-) Mice , 2018, Radiation Research.

[24]  Fabian J Theis,et al.  An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics , 2018, bioRxiv.

[25]  N. Gray,et al.  Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. , 2018, ACS chemical biology.

[26]  I. Arisi,et al.  Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation , 2018, PloS one.

[27]  S. Melov,et al.  Unmasking Transcriptional Heterogeneity in Senescent Cells , 2017, Current Biology.

[28]  M. Hew,et al.  CD11b immunophenotyping identifies inflammatory profiles in the mouse and human lungs , 2015, Mucosal Immunology.

[29]  C. Lowell,et al.  The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines , 2015, The Journal of Immunology.

[30]  A. Günther,et al.  The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis , 2015, European Respiratory Journal.

[31]  Alexander Pautsch,et al.  Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis , 2015, European Respiratory Journal.

[32]  M. Teixeira,et al.  Targeting CCL5 in inflammation , 2013, Expert opinion on therapeutic targets.

[33]  David B. Darr,et al.  Monitoring Tumorigenesis and Senescence In Vivo with a p16 INK4a -Luciferase Model , 2013, Cell.

[34]  S. Batra,et al.  Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure. , 2012, American journal of respiratory cell and molecular biology.

[35]  T. Luedde,et al.  Senescence surveillance of pre-malignant hepatocytes limits liver cancer development , 2011, Nature.

[36]  N. Shime,et al.  Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study , 2008, Respiratory research.

[37]  H. Bolte,et al.  Standardized quantification of pulmonary fibrosis in histological samples. , 2008, BioTechniques.

[38]  C. Agostini,et al.  Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis. , 2006, Proceedings of the American Thoracic Society.

[39]  J. Greenberger,et al.  Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. , 2003, American journal of respiratory cell and molecular biology.

[40]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[41]  J M Simpson,et al.  Simple method of estimating severity of pulmonary fibrosis on a numerical scale. , 1988, Journal of clinical pathology.

[42]  J. Saiz,et al.  Right‐sided non‐recurrent laryngeal nerve without any vascular anomaly: an anatomical trap , 2021, ANZ journal of surgery.

[43]  E. Redente,et al.  Isolation and Characterization of Mouse Fibroblasts. , 2018, Methods in molecular biology.

[44]  S. Rosselot Idiopathic pulmonary fibrosis. , 2014, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[45]  松山 広樹 Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors : an experimental study , 2009 .

[46]  D. Bar-Sagi,et al.  Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase–plasmid/liposomes (MnSOD–PL) during lung radioprotective gene therapy , 2003, Gene Therapy.

[47]  J. Elias,et al.  Bronchoalveolar Lavage: Role in the Pathogenesis, Diagnosis, and Management of Interstitial Lung Disease , 1985 .